Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy
Abstract Background Ferroptosis is a regulated cell death mode triggered by iron-dependent toxic membrane lipid peroxidation. As a novel cell death modality that is morphologically and mechanistically different from other forms of cell death, such as apoptosis and necrosis, ferroptosis has attracted...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-07-01
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| Series: | Experimental Hematology & Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40164-023-00427-w |
| _version_ | 1797769673528311808 |
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| author | Xiaogang Zheng Xiaodong Jin Fei Ye Xiongxiong Liu Boyi Yu Zheng Li Ting Zhao Weiqiang Chen Xinguo Liu Cuixia Di Qiang Li |
| author_facet | Xiaogang Zheng Xiaodong Jin Fei Ye Xiongxiong Liu Boyi Yu Zheng Li Ting Zhao Weiqiang Chen Xinguo Liu Cuixia Di Qiang Li |
| author_sort | Xiaogang Zheng |
| collection | DOAJ |
| description | Abstract Background Ferroptosis is a regulated cell death mode triggered by iron-dependent toxic membrane lipid peroxidation. As a novel cell death modality that is morphologically and mechanistically different from other forms of cell death, such as apoptosis and necrosis, ferroptosis has attracted extensive attention due to its association with various diseases. Evidence on ferroptosis as a potential therapeutic strategy has accumulated with the rapid growth of research on targeting ferroptosis for tumor suppression in recent years. Methods We summarize the currently known characteristics and major regulatory mechanisms of ferroptosis and present the role of ferroptosis in cellular stress responses, including ER stress and autophagy. Furthermore, we elucidate the potential applications of ferroptosis in radiotherapy and immunotherapy, which will be beneficial in exploring new strategies for clinical tumor treatment. Result and conclusion Based on specific biomarkers and precise patient-specific assessment, targeting ferroptosis has great potential to be translated into practical new approaches for clinical cancer therapy, significantly contributing to the prevention, diagnosis, prognosis, and treatment of cancer. |
| first_indexed | 2024-03-12T21:11:26Z |
| format | Article |
| id | doaj.art-e3ee95d8f6154381bc6567f7aa2e4738 |
| institution | Directory Open Access Journal |
| issn | 2162-3619 |
| language | English |
| last_indexed | 2024-03-12T21:11:26Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Experimental Hematology & Oncology |
| spelling | doaj.art-e3ee95d8f6154381bc6567f7aa2e47382023-07-30T11:09:30ZengBMCExperimental Hematology & Oncology2162-36192023-07-0112112010.1186/s40164-023-00427-wFerroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapyXiaogang Zheng0Xiaodong Jin1Fei Ye2Xiongxiong Liu3Boyi Yu4Zheng Li5Ting Zhao6Weiqiang Chen7Xinguo Liu8Cuixia Di9Qiang Li10Department of Medical Physics, Bio-Medical Research Center, Institute of Modern Physics, Chinese Academy of SciencesDepartment of Medical Physics, Bio-Medical Research Center, Institute of Modern Physics, Chinese Academy of SciencesDepartment of Medical Physics, Bio-Medical Research Center, Institute of Modern Physics, Chinese Academy of SciencesDepartment of Medical Physics, Bio-Medical Research Center, Institute of Modern Physics, Chinese Academy of SciencesDepartment of Medical Physics, Bio-Medical Research Center, Institute of Modern Physics, Chinese Academy of SciencesDivision of Thoracic Tumor Multimodality Treatment and Department of Radiation Oncology, Cancer Center, West China Hospital of Sichuan UniversityDepartment of Medical Physics, Bio-Medical Research Center, Institute of Modern Physics, Chinese Academy of SciencesDepartment of Medical Physics, Bio-Medical Research Center, Institute of Modern Physics, Chinese Academy of SciencesDepartment of Medical Physics, Bio-Medical Research Center, Institute of Modern Physics, Chinese Academy of SciencesDepartment of Medical Physics, Bio-Medical Research Center, Institute of Modern Physics, Chinese Academy of SciencesDepartment of Medical Physics, Bio-Medical Research Center, Institute of Modern Physics, Chinese Academy of SciencesAbstract Background Ferroptosis is a regulated cell death mode triggered by iron-dependent toxic membrane lipid peroxidation. As a novel cell death modality that is morphologically and mechanistically different from other forms of cell death, such as apoptosis and necrosis, ferroptosis has attracted extensive attention due to its association with various diseases. Evidence on ferroptosis as a potential therapeutic strategy has accumulated with the rapid growth of research on targeting ferroptosis for tumor suppression in recent years. Methods We summarize the currently known characteristics and major regulatory mechanisms of ferroptosis and present the role of ferroptosis in cellular stress responses, including ER stress and autophagy. Furthermore, we elucidate the potential applications of ferroptosis in radiotherapy and immunotherapy, which will be beneficial in exploring new strategies for clinical tumor treatment. Result and conclusion Based on specific biomarkers and precise patient-specific assessment, targeting ferroptosis has great potential to be translated into practical new approaches for clinical cancer therapy, significantly contributing to the prevention, diagnosis, prognosis, and treatment of cancer.https://doi.org/10.1186/s40164-023-00427-wFerroptosisLipid peroxidationER stressAutophagyRadiotherapyImmunotherapy |
| spellingShingle | Xiaogang Zheng Xiaodong Jin Fei Ye Xiongxiong Liu Boyi Yu Zheng Li Ting Zhao Weiqiang Chen Xinguo Liu Cuixia Di Qiang Li Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy Experimental Hematology & Oncology Ferroptosis Lipid peroxidation ER stress Autophagy Radiotherapy Immunotherapy |
| title | Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy |
| title_full | Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy |
| title_fullStr | Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy |
| title_full_unstemmed | Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy |
| title_short | Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy |
| title_sort | ferroptosis a novel regulated cell death participating in cellular stress response radiotherapy and immunotherapy |
| topic | Ferroptosis Lipid peroxidation ER stress Autophagy Radiotherapy Immunotherapy |
| url | https://doi.org/10.1186/s40164-023-00427-w |
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