Preliminary study about the relationship between estimated training status and RAS polymorphisms on blood pressure and ACE activity in the elderly
Objective: Polymorphisms of the renin angiotensin system (RAS) are associated with increases in blood pressure (BP). Physical exercise has been considered the main strategy to prevent this increase. This study aimed to investigate the relationship between estimated training status (TS), BP and angio...
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Format: | Article |
Language: | English |
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SAGE Publications
2018-06-01
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Series: | Journal of the Renin-Angiotensin-Aldosterone System |
Online Access: | https://doi.org/10.1177/1470320318782622 |
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author | Roberta Fernanda da Silva Riccardo Lacchini Lucas Cezar Pinheiro Thiago José Dionísio AndréMourão Jacomini José Eduardo Tanus-Santos Sandra Lia Amaral Carlos Ferreira Santos Anderson Saranz Zago |
author_facet | Roberta Fernanda da Silva Riccardo Lacchini Lucas Cezar Pinheiro Thiago José Dionísio AndréMourão Jacomini José Eduardo Tanus-Santos Sandra Lia Amaral Carlos Ferreira Santos Anderson Saranz Zago |
author_sort | Roberta Fernanda da Silva |
collection | DOAJ |
description | Objective: Polymorphisms of the renin angiotensin system (RAS) are associated with increases in blood pressure (BP). Physical exercise has been considered the main strategy to prevent this increase. This study aimed to investigate the relationship between estimated training status (TS), BP and angiotensin-converting enzyme (ACE) activity in elderly people classified as low or high risk to develop hypertension according to genetic profile. Methods: A total of 155 elderly participants performed the following assessments: general functional fitness index (GFFI), systolic BP (SBP) and diastolic BP (DBP), blood collection for ACE activity and analyses of the RAS polymorphisms. Results: Uncontrolled hypertensive (UHT) participants presented higher values of SBP and DBP compared with normotensive (NT) and controlled hypertensive (CHT) participants. No differences were found in ACE activity and GFFI between groups. In the high risk group, UHT presented higher values of SBP and DBP compared with other groups. CHT presented higher values of SBP compared with NT. Furthermore, UHT presented higher values of ACE activity compared with CHT and lower values of GFFI compared with NT. Conclusion: MDA, TIA and TIC genetic combinations were associated with high risk of developing hypertension while the maintenance of good levels of TS was associated with lower BP values and ACE activity. |
first_indexed | 2024-03-07T18:37:48Z |
format | Article |
id | doaj.art-e3efd915ca1d43798fce4f82cfe13653 |
institution | Directory Open Access Journal |
issn | 1752-8976 |
language | English |
last_indexed | 2024-03-07T18:37:48Z |
publishDate | 2018-06-01 |
publisher | SAGE Publications |
record_format | Article |
series | Journal of the Renin-Angiotensin-Aldosterone System |
spelling | doaj.art-e3efd915ca1d43798fce4f82cfe136532024-03-02T04:47:45ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1752-89762018-06-011910.1177/1470320318782622Preliminary study about the relationship between estimated training status and RAS polymorphisms on blood pressure and ACE activity in the elderlyRoberta Fernanda da Silva0Riccardo Lacchini1Lucas Cezar Pinheiro2Thiago José Dionísio3AndréMourão Jacomini4José Eduardo Tanus-Santos5Sandra Lia Amaral6Carlos Ferreira Santos7Anderson Saranz Zago8Department of Physical Education, São Paulo State University (UNESP), School of Science, Bauru, BrazilSchool of Nursing of Ribeirão Preto, USP - University of São Paulo, Ribeirão Preto, BrazilFaculty of Medicine of Ribeirão Preto, USP - University of São Paulo, Ribeirão Preto, BrazilBauru School of Dentistry, University of São Paulo, Bauru, BrazilDepartment of Physical Education, São Paulo State University (UNESP), School of Science, Bauru, BrazilFaculty of Medicine of Ribeirão Preto, USP - University of São Paulo, Ribeirão Preto, BrazilDepartment of Physical Education, São Paulo State University (UNESP), School of Science, Bauru, BrazilBauru School of Dentistry, University of São Paulo, Bauru, BrazilDepartment of Physical Education, São Paulo State University (UNESP), School of Science, Bauru, BrazilObjective: Polymorphisms of the renin angiotensin system (RAS) are associated with increases in blood pressure (BP). Physical exercise has been considered the main strategy to prevent this increase. This study aimed to investigate the relationship between estimated training status (TS), BP and angiotensin-converting enzyme (ACE) activity in elderly people classified as low or high risk to develop hypertension according to genetic profile. Methods: A total of 155 elderly participants performed the following assessments: general functional fitness index (GFFI), systolic BP (SBP) and diastolic BP (DBP), blood collection for ACE activity and analyses of the RAS polymorphisms. Results: Uncontrolled hypertensive (UHT) participants presented higher values of SBP and DBP compared with normotensive (NT) and controlled hypertensive (CHT) participants. No differences were found in ACE activity and GFFI between groups. In the high risk group, UHT presented higher values of SBP and DBP compared with other groups. CHT presented higher values of SBP compared with NT. Furthermore, UHT presented higher values of ACE activity compared with CHT and lower values of GFFI compared with NT. Conclusion: MDA, TIA and TIC genetic combinations were associated with high risk of developing hypertension while the maintenance of good levels of TS was associated with lower BP values and ACE activity.https://doi.org/10.1177/1470320318782622 |
spellingShingle | Roberta Fernanda da Silva Riccardo Lacchini Lucas Cezar Pinheiro Thiago José Dionísio AndréMourão Jacomini José Eduardo Tanus-Santos Sandra Lia Amaral Carlos Ferreira Santos Anderson Saranz Zago Preliminary study about the relationship between estimated training status and RAS polymorphisms on blood pressure and ACE activity in the elderly Journal of the Renin-Angiotensin-Aldosterone System |
title | Preliminary study about the relationship between estimated training status and RAS polymorphisms on blood pressure and ACE activity in the elderly |
title_full | Preliminary study about the relationship between estimated training status and RAS polymorphisms on blood pressure and ACE activity in the elderly |
title_fullStr | Preliminary study about the relationship between estimated training status and RAS polymorphisms on blood pressure and ACE activity in the elderly |
title_full_unstemmed | Preliminary study about the relationship between estimated training status and RAS polymorphisms on blood pressure and ACE activity in the elderly |
title_short | Preliminary study about the relationship between estimated training status and RAS polymorphisms on blood pressure and ACE activity in the elderly |
title_sort | preliminary study about the relationship between estimated training status and ras polymorphisms on blood pressure and ace activity in the elderly |
url | https://doi.org/10.1177/1470320318782622 |
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