Subversion of host cell signaling: The arsenal of Rickettsial species
Rickettsia is a genus of nonmotile, Gram-negative, non-spore-forming, highly pleomorphic bacteria that cause severe epidemic rickettsioses. The spotted fever group and typhi group are major members of the genus Rickettsia. Rickettsial species from the two groups subvert diverse host cellular process...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2022.995933/full |
| _version_ | 1797991582406803456 |
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| author | Dan Huang Jingjing Luo Xuan OuYang Lei Song |
| author_facet | Dan Huang Jingjing Luo Xuan OuYang Lei Song |
| author_sort | Dan Huang |
| collection | DOAJ |
| description | Rickettsia is a genus of nonmotile, Gram-negative, non-spore-forming, highly pleomorphic bacteria that cause severe epidemic rickettsioses. The spotted fever group and typhi group are major members of the genus Rickettsia. Rickettsial species from the two groups subvert diverse host cellular processes, including membrane dynamics, actin cytoskeleton dynamics, phosphoinositide metabolism, intracellular trafficking, and immune defense, to promote their host colonization and intercellular transmission through secreted effectors (virulence factors). However, lineage-specific rickettsiae have exploited divergent strategies to accomplish such challenging tasks and these elaborated strategies focus on distinct host cell processes. In the present review, we summarized current understandings of how different rickettsial species employ their effectors’ arsenal to affect host cellular processes in order to promote their own replication or to avoid destruction. |
| first_indexed | 2024-04-11T08:54:35Z |
| format | Article |
| id | doaj.art-e3f06508796a46808e794a6209b05cd4 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-04-11T08:54:35Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-e3f06508796a46808e794a6209b05cd42022-12-22T04:33:20ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882022-10-011210.3389/fcimb.2022.995933995933Subversion of host cell signaling: The arsenal of Rickettsial speciesDan Huang0Jingjing Luo1Xuan OuYang2Lei Song3Department of Respiratory Medicine, Center of Pathogen Biology and Infectious Disease, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, ChinaDepartment of Respiratory Medicine, Center of Pathogen Biology and Infectious Disease, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, ChinaState Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, ChinaDepartment of Respiratory Medicine, Center of Pathogen Biology and Infectious Disease, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, ChinaRickettsia is a genus of nonmotile, Gram-negative, non-spore-forming, highly pleomorphic bacteria that cause severe epidemic rickettsioses. The spotted fever group and typhi group are major members of the genus Rickettsia. Rickettsial species from the two groups subvert diverse host cellular processes, including membrane dynamics, actin cytoskeleton dynamics, phosphoinositide metabolism, intracellular trafficking, and immune defense, to promote their host colonization and intercellular transmission through secreted effectors (virulence factors). However, lineage-specific rickettsiae have exploited divergent strategies to accomplish such challenging tasks and these elaborated strategies focus on distinct host cell processes. In the present review, we summarized current understandings of how different rickettsial species employ their effectors’ arsenal to affect host cellular processes in order to promote their own replication or to avoid destruction.https://www.frontiersin.org/articles/10.3389/fcimb.2022.995933/fullType IV secretion systemeffectorvirulenceinvasionactinphosphoinositide |
| spellingShingle | Dan Huang Jingjing Luo Xuan OuYang Lei Song Subversion of host cell signaling: The arsenal of Rickettsial species Frontiers in Cellular and Infection Microbiology Type IV secretion system effector virulence invasion actin phosphoinositide |
| title | Subversion of host cell signaling: The arsenal of Rickettsial species |
| title_full | Subversion of host cell signaling: The arsenal of Rickettsial species |
| title_fullStr | Subversion of host cell signaling: The arsenal of Rickettsial species |
| title_full_unstemmed | Subversion of host cell signaling: The arsenal of Rickettsial species |
| title_short | Subversion of host cell signaling: The arsenal of Rickettsial species |
| title_sort | subversion of host cell signaling the arsenal of rickettsial species |
| topic | Type IV secretion system effector virulence invasion actin phosphoinositide |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2022.995933/full |
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