Effectiveness of Butorphanol in alleviating intra- and post-operative visceral pain following microwave ablation for hepatic tumor: a dual-central, randomized, controlled trial
Abstract Many patients who underwent hepatic percutaneous microwave ablation (MWA) reported experiencing pain during the procedure. This study utilized a well-designed multicentral, randomized, and placebo-controlled format to investigate the effects of Butorphanol. Patients who underwent MWA were r...
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Nature Portfolio
2024-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-56876-8 |
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| author | Bibo Wang Neng Wang Zhiyue Zhao Shengxi Huang Qiang Shen Sheng Liu Pingsheng Zhou Lu Lu Guojun Qian |
| author_facet | Bibo Wang Neng Wang Zhiyue Zhao Shengxi Huang Qiang Shen Sheng Liu Pingsheng Zhou Lu Lu Guojun Qian |
| author_sort | Bibo Wang |
| collection | DOAJ |
| description | Abstract Many patients who underwent hepatic percutaneous microwave ablation (MWA) reported experiencing pain during the procedure. This study utilized a well-designed multicentral, randomized, and placebo-controlled format to investigate the effects of Butorphanol. Patients who underwent MWA were randomly assigned to either Butorphanol or normal saline group. The primary outcomes of the study were assessed by measuring the patients' intraoperative pain levels using a 10-point visual analog scale (VAS). Secondary outcomes included measuring postoperative pain levels at the 6-h mark (VAS) and evaluating comprehensive pain assessment outcomes. A total of 300 patients were divided between the control group (n = 100) and the experimental group (n = 200). Butorphanol showed statistically significant reductions in intraoperative pain levels compared to the placebo during surgery (5.00 ± 1.46 vs. 3.54 ± 1.67, P < 0.001). Significant differences were observed in postoperative pain levels at the 6-h mark and in the overall assessment of pain (1.39 + 1.21 vs. 0.65 + 0.81, P < 0.001). Butorphanol had a significant impact on reducing the heart rate of patients. The empirical evidence supports the effectiveness of Butorphanol in reducing the occurrence of visceral postoperative pain in patients undergoing microwave ablation for hepatic tumor. Furthermore, the study found no noticeable impact on circulatory and respiratory dynamics. |
| first_indexed | 2024-04-24T19:56:31Z |
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| id | doaj.art-e3f3d6023aa94c068d5db457807e64ab |
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| language | English |
| last_indexed | 2024-04-24T19:56:31Z |
| publishDate | 2024-03-01 |
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| spelling | doaj.art-e3f3d6023aa94c068d5db457807e64ab2024-03-24T12:21:09ZengNature PortfolioScientific Reports2045-23222024-03-011411810.1038/s41598-024-56876-8Effectiveness of Butorphanol in alleviating intra- and post-operative visceral pain following microwave ablation for hepatic tumor: a dual-central, randomized, controlled trialBibo Wang0Neng Wang1Zhiyue Zhao2Shengxi Huang3Qiang Shen4Sheng Liu5Pingsheng Zhou6Lu Lu7Guojun Qian8Department of Minimally Intervention Therapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University/NAVAL Medical UniversityDepartment of Minimally Intervention Therapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University/NAVAL Medical UniversityDepartment of Medical Oncology, Jinling Hospital, Affiliated Hospital of Medicine School, Nanjing UniversityDepartment of Special Clinic, Affiliated Hospital of Medicine School, Jinling Hospital, Nanjing UniversityDepartment of Minimally Intervention Therapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University/NAVAL Medical UniversityDepartment of Minimally Intervention Therapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University/NAVAL Medical UniversityDepartment of Minimally Intervention Therapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University/NAVAL Medical UniversityDepartment of Medical Oncology, Jinling Hospital, Affiliated Hospital of Medicine School, Nanjing UniversityDepartment of Minimally Intervention Therapy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University/NAVAL Medical UniversityAbstract Many patients who underwent hepatic percutaneous microwave ablation (MWA) reported experiencing pain during the procedure. This study utilized a well-designed multicentral, randomized, and placebo-controlled format to investigate the effects of Butorphanol. Patients who underwent MWA were randomly assigned to either Butorphanol or normal saline group. The primary outcomes of the study were assessed by measuring the patients' intraoperative pain levels using a 10-point visual analog scale (VAS). Secondary outcomes included measuring postoperative pain levels at the 6-h mark (VAS) and evaluating comprehensive pain assessment outcomes. A total of 300 patients were divided between the control group (n = 100) and the experimental group (n = 200). Butorphanol showed statistically significant reductions in intraoperative pain levels compared to the placebo during surgery (5.00 ± 1.46 vs. 3.54 ± 1.67, P < 0.001). Significant differences were observed in postoperative pain levels at the 6-h mark and in the overall assessment of pain (1.39 + 1.21 vs. 0.65 + 0.81, P < 0.001). Butorphanol had a significant impact on reducing the heart rate of patients. The empirical evidence supports the effectiveness of Butorphanol in reducing the occurrence of visceral postoperative pain in patients undergoing microwave ablation for hepatic tumor. Furthermore, the study found no noticeable impact on circulatory and respiratory dynamics.https://doi.org/10.1038/s41598-024-56876-8ButorphanolMicrowave ablationHepatic tumorRCT |
| spellingShingle | Bibo Wang Neng Wang Zhiyue Zhao Shengxi Huang Qiang Shen Sheng Liu Pingsheng Zhou Lu Lu Guojun Qian Effectiveness of Butorphanol in alleviating intra- and post-operative visceral pain following microwave ablation for hepatic tumor: a dual-central, randomized, controlled trial Scientific Reports Butorphanol Microwave ablation Hepatic tumor RCT |
| title | Effectiveness of Butorphanol in alleviating intra- and post-operative visceral pain following microwave ablation for hepatic tumor: a dual-central, randomized, controlled trial |
| title_full | Effectiveness of Butorphanol in alleviating intra- and post-operative visceral pain following microwave ablation for hepatic tumor: a dual-central, randomized, controlled trial |
| title_fullStr | Effectiveness of Butorphanol in alleviating intra- and post-operative visceral pain following microwave ablation for hepatic tumor: a dual-central, randomized, controlled trial |
| title_full_unstemmed | Effectiveness of Butorphanol in alleviating intra- and post-operative visceral pain following microwave ablation for hepatic tumor: a dual-central, randomized, controlled trial |
| title_short | Effectiveness of Butorphanol in alleviating intra- and post-operative visceral pain following microwave ablation for hepatic tumor: a dual-central, randomized, controlled trial |
| title_sort | effectiveness of butorphanol in alleviating intra and post operative visceral pain following microwave ablation for hepatic tumor a dual central randomized controlled trial |
| topic | Butorphanol Microwave ablation Hepatic tumor RCT |
| url | https://doi.org/10.1038/s41598-024-56876-8 |
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