Low double-negative CD3+CD4-CD8- T cells are associated with incomplete restoration of CD4+ T cells and higher immune activation in HIV-1 immunological non-responders

Low double-negative CD3+CD4-CD8- T cells are associated with incomplete restoration of CD4+ T cells and higher immune activation in HIV-1 immunological non-responders

Failure of immune reconstitution increases the risk of AIDS or non-AIDS related morbidity and mortality in HIV-1-infected patients. CD3+CD4-CD8- T cells, which are usually described as double negative (DN) T cells, display CD4-like helper and immunoregulatory functions. Here, we have measured the pe...

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Bibliographic Details
Main Authors: Xiaofan LU, Bin SU, Huan XIA, Xin ZHANG, Zhiying LIU, Yunxia JI, Zixuan YANG, Lili DAI, Luzia M. MAYR, Christiane MOOG, Hao WU, Xiaojie HUANG, Tong ZHANG
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Immunology
Subjects:
HIV-1
Immune reconstitution
immune activation
antiretroviral therapy
Double-negative T cell
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00579/full

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