The GluN2B-Selective Antagonist Ro 25-6981 Is Effective against PTZ-Induced Seizures and Safe for Further Development in Infantile Rats

The GluN2B-Selective Antagonist Ro 25-6981 Is Effective against PTZ-Induced Seizures and Safe for Further Development in Infantile Rats

The GluN2B subunit of NMDA receptors represents a perspective therapeutic target in various CNS pathologies, including epilepsy. Because of its predominant expression in the immature brain, selective GluN2B antagonists are expected to be more effective early in postnatal development. The aim of this...

Full description

Bibliographic Details
Main Authors: Pavel Mareš, Lucie Kozlová, Anna Mikulecká, Hana Kubová
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceutics
Subjects:
development
GluN2B-selective antagonist
Ro 25-6981
anti-seizure effects
motor performance
memory
Online Access:https://www.mdpi.com/1999-4923/13/9/1482

Similar Items

Similar Items