PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER
ABSTRACT Background: The carcinoembryonic antigen level in peritoneal lavage has been showing to be a reliable prognostic factor in gastric cancer. Aim: To identify any association between carcinoembryonic antigen level in peritoneal lavage, in gastric cancer patients, with mortality, peritoneal...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Colégio Brasileiro de Cirurgia Digestiva
2018-06-01
|
| Series: | ABCD: Arquivos Brasileiros de Cirurgia Digestiva |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202018000100319&tlng=pt |
| _version_ | 1819002859015897088 |
|---|---|
| author | Letícia Biscaino ALVES Maria Teresa TSUKAZAN Ana Elisa SERAFIM Rolando MENDOZA Alexandre Vontobel PADOIN Plínio Carlos BAÚ Luis Fernando MOREIRA |
| author_facet | Letícia Biscaino ALVES Maria Teresa TSUKAZAN Ana Elisa SERAFIM Rolando MENDOZA Alexandre Vontobel PADOIN Plínio Carlos BAÚ Luis Fernando MOREIRA |
| author_sort | Letícia Biscaino ALVES |
| collection | DOAJ |
| description | ABSTRACT Background: The carcinoembryonic antigen level in peritoneal lavage has been showing to be a reliable prognostic factor in gastric cancer. Aim: To identify any association between carcinoembryonic antigen level in peritoneal lavage, in gastric cancer patients, with mortality, peritoneal recurrence, tumor relapse or other prognostic factors. Methods: In total, 30 patients (22 men, 8 women; median age 66 years) with resectable gastric cancer (mainly stage III and IV) were studied. Carcinoembryonic antigen level in peritoneal lavage was detected at operation by immunocytochemical method and a level over 210 ng/g of protein was considered as positive. Results: There were detected 10 positive cases (33.3%) of plCEA levels. These levels were associated with mortality, RR: 2.1 (p=0.018); peritoneal recurrence, OR: 9.0 (p=0.015); and relapse or gastric cancer progression, OR: 27.0 (p=0.001). Conclusion: Increased levels of plCEA fairly predicts mortality, peritoneal recurrence tumor relapse or cancer progression. |
| first_indexed | 2024-12-20T23:11:48Z |
| format | Article |
| id | doaj.art-e3f6f15d85fa44ec8b0e59a0e7681413 |
| institution | Directory Open Access Journal |
| issn | 0102-6720 |
| language | English |
| last_indexed | 2024-12-20T23:11:48Z |
| publishDate | 2018-06-01 |
| publisher | Colégio Brasileiro de Cirurgia Digestiva |
| record_format | Article |
| series | ABCD: Arquivos Brasileiros de Cirurgia Digestiva |
| spelling | doaj.art-e3f6f15d85fa44ec8b0e59a0e76814132022-12-21T19:23:43ZengColégio Brasileiro de Cirurgia DigestivaABCD: Arquivos Brasileiros de Cirurgia Digestiva0102-67202018-06-0131110.1590/0102-672020180001e1358PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCERLetícia Biscaino ALVESMaria Teresa TSUKAZANAna Elisa SERAFIMRolando MENDOZAAlexandre Vontobel PADOINPlínio Carlos BAÚLuis Fernando MOREIRAABSTRACT Background: The carcinoembryonic antigen level in peritoneal lavage has been showing to be a reliable prognostic factor in gastric cancer. Aim: To identify any association between carcinoembryonic antigen level in peritoneal lavage, in gastric cancer patients, with mortality, peritoneal recurrence, tumor relapse or other prognostic factors. Methods: In total, 30 patients (22 men, 8 women; median age 66 years) with resectable gastric cancer (mainly stage III and IV) were studied. Carcinoembryonic antigen level in peritoneal lavage was detected at operation by immunocytochemical method and a level over 210 ng/g of protein was considered as positive. Results: There were detected 10 positive cases (33.3%) of plCEA levels. These levels were associated with mortality, RR: 2.1 (p=0.018); peritoneal recurrence, OR: 9.0 (p=0.015); and relapse or gastric cancer progression, OR: 27.0 (p=0.001). Conclusion: Increased levels of plCEA fairly predicts mortality, peritoneal recurrence tumor relapse or cancer progression.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202018000100319&tlng=ptCarcinoembryonic antigenPeritoneal lavageGastric cancerPeritoneal recurrenceMortality |
| spellingShingle | Letícia Biscaino ALVES Maria Teresa TSUKAZAN Ana Elisa SERAFIM Rolando MENDOZA Alexandre Vontobel PADOIN Plínio Carlos BAÚ Luis Fernando MOREIRA PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER ABCD: Arquivos Brasileiros de Cirurgia Digestiva Carcinoembryonic antigen Peritoneal lavage Gastric cancer Peritoneal recurrence Mortality |
| title | PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER |
| title_full | PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER |
| title_fullStr | PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER |
| title_full_unstemmed | PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER |
| title_short | PROGNOSTIC VALUE OF CARCINOEMBRYONIC ANTIGEN LEVELS IN TRANSOPERATIVE PERITONEAL LAVAGE IN PATIENTS WITH GASTRIC CANCER |
| title_sort | prognostic value of carcinoembryonic antigen levels in transoperative peritoneal lavage in patients with gastric cancer |
| topic | Carcinoembryonic antigen Peritoneal lavage Gastric cancer Peritoneal recurrence Mortality |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202018000100319&tlng=pt |
| work_keys_str_mv | AT leticiabiscainoalves prognosticvalueofcarcinoembryonicantigenlevelsintransoperativeperitoneallavageinpatientswithgastriccancer AT mariateresatsukazan prognosticvalueofcarcinoembryonicantigenlevelsintransoperativeperitoneallavageinpatientswithgastriccancer AT anaelisaserafim prognosticvalueofcarcinoembryonicantigenlevelsintransoperativeperitoneallavageinpatientswithgastriccancer AT rolandomendoza prognosticvalueofcarcinoembryonicantigenlevelsintransoperativeperitoneallavageinpatientswithgastriccancer AT alexandrevontobelpadoin prognosticvalueofcarcinoembryonicantigenlevelsintransoperativeperitoneallavageinpatientswithgastriccancer AT pliniocarlosbau prognosticvalueofcarcinoembryonicantigenlevelsintransoperativeperitoneallavageinpatientswithgastriccancer AT luisfernandomoreira prognosticvalueofcarcinoembryonicantigenlevelsintransoperativeperitoneallavageinpatientswithgastriccancer |