Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review
Microbial secondary metabolites (MSMs) have played and continue to play a highly significant role in the drug discovery and development process. Genetically, MSM chemical structures are biologically synthesized by microbial gene clusters. Recently, however, the speed of new bioactive MSM discovery h...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-02-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2019.00294/full |
| _version_ | 1811219325138239488 |
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| author | Rui Pan Xuelian Bai Jianwei Chen Huawei Zhang Hong Wang |
| author_facet | Rui Pan Xuelian Bai Jianwei Chen Huawei Zhang Hong Wang |
| author_sort | Rui Pan |
| collection | DOAJ |
| description | Microbial secondary metabolites (MSMs) have played and continue to play a highly significant role in the drug discovery and development process. Genetically, MSM chemical structures are biologically synthesized by microbial gene clusters. Recently, however, the speed of new bioactive MSM discovery has been slowing down due to consistent employment of conventional cultivation and isolation procedure. In order to alleviate this challenge, a number of new approaches have been developed. The strategy of one strain many compounds (OSMAC) has been shown as a simple and powerful tool that can activate many silent biogenetic gene clusters in microorganisms to make more natural products. This review highlights important and successful examples using OSMAC approaches, which covers changing medium composition and cultivation status, co-cultivation with other strain(s), adding enzyme inhibitor(s) and MSM biosynthetic precursor(s). Available evidences had shown that variation of cultivation condition is the most effective way to produce more MSMs and facilitate the discovery of new therapeutic agents. |
| first_indexed | 2024-04-12T07:25:26Z |
| format | Article |
| id | doaj.art-e3f76aa1b67a409fb68c2122e5efb82b |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-12T07:25:26Z |
| publishDate | 2019-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-e3f76aa1b67a409fb68c2122e5efb82b2022-12-22T03:42:13ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2019-02-011010.3389/fmicb.2019.00294418973Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature ReviewRui Pan0Xuelian Bai1Jianwei Chen2Huawei Zhang3Hong Wang4School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, ChinaCollege of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, ChinaSchool of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, ChinaSchool of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, ChinaSchool of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, ChinaMicrobial secondary metabolites (MSMs) have played and continue to play a highly significant role in the drug discovery and development process. Genetically, MSM chemical structures are biologically synthesized by microbial gene clusters. Recently, however, the speed of new bioactive MSM discovery has been slowing down due to consistent employment of conventional cultivation and isolation procedure. In order to alleviate this challenge, a number of new approaches have been developed. The strategy of one strain many compounds (OSMAC) has been shown as a simple and powerful tool that can activate many silent biogenetic gene clusters in microorganisms to make more natural products. This review highlights important and successful examples using OSMAC approaches, which covers changing medium composition and cultivation status, co-cultivation with other strain(s), adding enzyme inhibitor(s) and MSM biosynthetic precursor(s). Available evidences had shown that variation of cultivation condition is the most effective way to produce more MSMs and facilitate the discovery of new therapeutic agents.https://www.frontiersin.org/article/10.3389/fmicb.2019.00294/fullOSMAC strategymicrobe secondary metabolitestructural diversitymedium compositionco-cultivationepigenetic modification |
| spellingShingle | Rui Pan Xuelian Bai Jianwei Chen Huawei Zhang Hong Wang Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review Frontiers in Microbiology OSMAC strategy microbe secondary metabolite structural diversity medium composition co-cultivation epigenetic modification |
| title | Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review |
| title_full | Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review |
| title_fullStr | Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review |
| title_full_unstemmed | Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review |
| title_short | Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review |
| title_sort | exploring structural diversity of microbe secondary metabolites using osmac strategy a literature review |
| topic | OSMAC strategy microbe secondary metabolite structural diversity medium composition co-cultivation epigenetic modification |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2019.00294/full |
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