Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review

Exploring Structural Diversity of Microbe Secondary Metabolites Using OSMAC Strategy: A Literature Review

Microbial secondary metabolites (MSMs) have played and continue to play a highly significant role in the drug discovery and development process. Genetically, MSM chemical structures are biologically synthesized by microbial gene clusters. Recently, however, the speed of new bioactive MSM discovery h...

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Bibliographic Details
Main Authors: Rui Pan, Xuelian Bai, Jianwei Chen, Huawei Zhang, Hong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Microbiology
Subjects:
OSMAC strategy
microbe secondary metabolite
structural diversity
medium composition
co-cultivation
epigenetic modification
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00294/full

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