D-4F reduces EO6 immunoreactivity, SREBP-1c mRNA levels, and renal inflammation in LDL receptor-null mice fed a Western diet

D-4F reduces EO6 immunoreactivity, SREBP-1c mRNA levels, and renal inflammation in LDL receptor-null mice fed a Western diet

LDL receptor-null (LDLR−/−) mice on a Western diet (WD) develop endothelial dysfunction and atherosclerosis, which are improved by the apolipoprotein A-I (apoA-I) mimetic peptide D-4F. Focusing on the kidney, LDLR−/−mice were fed a WD with D-4F or the inactive control peptide scrambled D-4F (ScD-4F)...

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Bibliographic Details
Main Authors: Georgette M. Buga, Joy S. Frank, Giuliano A. Mottino, Ashkan Hakhamian, Ajay Narasimha, Andrew D. Watson, Babak Yekta, Mohamad Navab, Srinivasa T. Reddy, G.M. Anantharamaiah, Alan M. Fogelman
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:Journal of Lipid Research
Subjects:
atherosclerosis
apolipoprotein A-I mimetic peptides
HDL
hyperlipidemia
kidney
lipoproteins
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520428949

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