| Summary: | Herbal medicine is a conventional medicinal option for many people, particularly in developing countries, to cure diseases, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Propolis is one of the popular herbal medicine which has various health benefits, particularly antiviral activity. In this molecular docking study, our investigation examined 25 kinds of Propolis to bind SARS-CoV-2 protein with the main targets of ACE-2 and MPro receptors. Propolis ligands were downloaded from PubChem, ACE-2, and MProreceptors from Protein Data Bank. Both ligands and targets were optimized by PyMOL. The pharmacokinetics and toxicity analysis was conducted using OSIRIS software. Moleculardocking was done using PyRx 0.9, and its binding interaction was visualized by Discovery Studio.There were two com-pounds with the strongest interactions with ACE-2 and MPro receptors: Kaemferoland Abietic acid. Pharmacokinetic analysis revealed that these drugs have good phar-macokinetic properties. However, the findings of toxicity tests indicated that Kaempferol has the potential to be mutagenic. Kaempferol and Abietic acid com-pounds bind to Mpro and ACE-2 receptors and could be used to treat SARS-CoV 2 infection. However, further study on the efficacy and toxicity of this compound is required before it may be administered to humans.
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