Eicosanoid Control Over Antigen Presenting Cells in Asthma
Asthma is a common lung disease affecting 300 million people worldwide. Allergic asthma is recognized as a prototypical Th2 disorder, orchestrated by an aberrant adaptive CD4+ T helper (Th2/Th17) cell immune response against airborne allergens, that leads to eosinophilic inflammation, reversible bro...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02006/full |
| _version_ | 1819052116317044736 |
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| author | Nincy Debeuf Nincy Debeuf Bart N. Lambrecht Bart N. Lambrecht Bart N. Lambrecht |
| author_facet | Nincy Debeuf Nincy Debeuf Bart N. Lambrecht Bart N. Lambrecht Bart N. Lambrecht |
| author_sort | Nincy Debeuf |
| collection | DOAJ |
| description | Asthma is a common lung disease affecting 300 million people worldwide. Allergic asthma is recognized as a prototypical Th2 disorder, orchestrated by an aberrant adaptive CD4+ T helper (Th2/Th17) cell immune response against airborne allergens, that leads to eosinophilic inflammation, reversible bronchoconstriction, and mucus overproduction. Other forms of asthma are controlled by an eosinophil-rich innate ILC2 response driven by epithelial damage, whereas in some patients with more neutrophilia, the disease is driven by Th17 cells. Dendritic cells (DCs) and macrophages are crucial regulators of type 2 immunity in asthma. Numerous lipid mediators including the eicosanoids prostaglandins and leukotrienes influence key functions of these cells, leading to either pro- or anti-inflammatory effects on disease outcome. In this review, we will discuss how eicosanoids affect the functions of DCs and macrophages in the asthmatic lung and how this leads to aberrant T cell differentiation that causes disease. |
| first_indexed | 2024-12-21T12:14:43Z |
| format | Article |
| id | doaj.art-e3f7d8e5174f4180b2a76728727ccb7d |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T12:14:43Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e3f7d8e5174f4180b2a76728727ccb7d2022-12-21T19:04:28ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-09-01910.3389/fimmu.2018.02006411860Eicosanoid Control Over Antigen Presenting Cells in AsthmaNincy Debeuf0Nincy Debeuf1Bart N. Lambrecht2Bart N. Lambrecht3Bart N. Lambrecht4Laboratory of Immunoregulation, VIB-UGent Center for Inflammation Research, Ghent, BelgiumDepartment of Internal Medicine, Ghent University, Ghent, BelgiumLaboratory of Immunoregulation, VIB-UGent Center for Inflammation Research, Ghent, BelgiumDepartment of Internal Medicine, Ghent University, Ghent, BelgiumDepartment of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, NetherlandsAsthma is a common lung disease affecting 300 million people worldwide. Allergic asthma is recognized as a prototypical Th2 disorder, orchestrated by an aberrant adaptive CD4+ T helper (Th2/Th17) cell immune response against airborne allergens, that leads to eosinophilic inflammation, reversible bronchoconstriction, and mucus overproduction. Other forms of asthma are controlled by an eosinophil-rich innate ILC2 response driven by epithelial damage, whereas in some patients with more neutrophilia, the disease is driven by Th17 cells. Dendritic cells (DCs) and macrophages are crucial regulators of type 2 immunity in asthma. Numerous lipid mediators including the eicosanoids prostaglandins and leukotrienes influence key functions of these cells, leading to either pro- or anti-inflammatory effects on disease outcome. In this review, we will discuss how eicosanoids affect the functions of DCs and macrophages in the asthmatic lung and how this leads to aberrant T cell differentiation that causes disease.https://www.frontiersin.org/article/10.3389/fimmu.2018.02006/fulleicosanoidsprostaglandinsleukotrienesasthmadendritic cellsmacrophages |
| spellingShingle | Nincy Debeuf Nincy Debeuf Bart N. Lambrecht Bart N. Lambrecht Bart N. Lambrecht Eicosanoid Control Over Antigen Presenting Cells in Asthma Frontiers in Immunology eicosanoids prostaglandins leukotrienes asthma dendritic cells macrophages |
| title | Eicosanoid Control Over Antigen Presenting Cells in Asthma |
| title_full | Eicosanoid Control Over Antigen Presenting Cells in Asthma |
| title_fullStr | Eicosanoid Control Over Antigen Presenting Cells in Asthma |
| title_full_unstemmed | Eicosanoid Control Over Antigen Presenting Cells in Asthma |
| title_short | Eicosanoid Control Over Antigen Presenting Cells in Asthma |
| title_sort | eicosanoid control over antigen presenting cells in asthma |
| topic | eicosanoids prostaglandins leukotrienes asthma dendritic cells macrophages |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02006/full |
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