Hyperlipidemia in COPD is associated with decreased incidence of pneumonia and mortality: a nationwide health insurance data-based retrospective cohort study
Ming-Chen Chan,1–3 Ching-Heng Lin,4 Yu Ru Kou1 1Institute of Physiology, National Yang-Ming University, Taipei, 2Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, 3College of Nursing, Central Taiwan University of Science and Technology, 4Depa...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2016-05-01
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| Series: | International Journal of COPD |
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| Online Access: | https://www.dovepress.com/hyperlipidemia-in-copd-is-associated-with-decreased-incidence-of-pneum-peer-reviewed-article-COPD |
| _version_ | 1818498426189381632 |
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| author | Chan MC Lin CH Kou YR |
| author_facet | Chan MC Lin CH Kou YR |
| author_sort | Chan MC |
| collection | DOAJ |
| description | Ming-Chen Chan,1–3 Ching-Heng Lin,4 Yu Ru Kou1 1Institute of Physiology, National Yang-Ming University, Taipei, 2Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, 3College of Nursing, Central Taiwan University of Science and Technology, 4Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan Purpose: COPD is often associated with various comorbidities that may influence its outcomes. Pneumonia, cardiovascular disease (CVD), and cancer are the major causes of death in COPD patients. The objective of this study is to investigate the influence of comorbidities on COPD by using the Taiwan National Health Insurance database.Patients and methods: We retrospectively analyzed the database in 2006 of one million sampling cohort. Newly diagnosed patients with COPD with a controlled cohort that was matched by age, sex, and Charlson comorbidity index (CCI) were included for analysis.Results: In total, 1,491 patients with COPD were included for analysis (61.8% male). Patients with COPD had higher incidences of pneumonia (25.7% vs 10.4%; P<0.0001), CVD (15.1% vs 10.5%; P<0.0001), and mortality rate (26.6% vs 15.8%; P<0.001) compared with the control group in the 4-year follow-up. In patients with COPD, CCI ≥3 have a higher incidence of pneumonia (hazard ratio [HR] 1.61; 95% confidence interval [CI] 1.23–2.09; P<0.0001), CVD (HR 1.73; 95% CI 1.24–2.41; P=0.001), and mortality (HR 1.12; 95% CI 1.12–1.83; P=0.004). Among the major comorbidities of COPD, hyperlipidemia was associated with decreased incidence of pneumonia (HR 0.68; 95% CI 0.5–0.93; P=0.016) and mortality (HR 0.64; 95% CI 0.46–0.90; P=0.009), but was not associated with increased risk of CVD (HR 1.10; 95% CI 0.78–1.55; P=0.588).Conclusion: Our results demonstrate that COPD is associated with increased incidence of pneumonia, CVD, and mortality. In patients with COPD, higher CCI is associated with increased incidence of pneumonia, CVD, and mortality. However, COPD with hyperlipidemia is associated with decreased incidence of pneumonia and mortality. Keywords: COPD, hyperlipidemia, pneumonia, mortality |
| first_indexed | 2024-12-10T18:58:40Z |
| format | Article |
| id | doaj.art-e3f855e1b69b400c8b0617a7833adae4 |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-12-10T18:58:40Z |
| publishDate | 2016-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-e3f855e1b69b400c8b0617a7833adae42022-12-22T01:37:05ZengDove Medical PressInternational Journal of COPD1178-20052016-05-012016Issue 11053105926988Hyperlipidemia in COPD is associated with decreased incidence of pneumonia and mortality: a nationwide health insurance data-based retrospective cohort studyChan MCLin CHKou YRMing-Chen Chan,1–3 Ching-Heng Lin,4 Yu Ru Kou1 1Institute of Physiology, National Yang-Ming University, Taipei, 2Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, 3College of Nursing, Central Taiwan University of Science and Technology, 4Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan Purpose: COPD is often associated with various comorbidities that may influence its outcomes. Pneumonia, cardiovascular disease (CVD), and cancer are the major causes of death in COPD patients. The objective of this study is to investigate the influence of comorbidities on COPD by using the Taiwan National Health Insurance database.Patients and methods: We retrospectively analyzed the database in 2006 of one million sampling cohort. Newly diagnosed patients with COPD with a controlled cohort that was matched by age, sex, and Charlson comorbidity index (CCI) were included for analysis.Results: In total, 1,491 patients with COPD were included for analysis (61.8% male). Patients with COPD had higher incidences of pneumonia (25.7% vs 10.4%; P<0.0001), CVD (15.1% vs 10.5%; P<0.0001), and mortality rate (26.6% vs 15.8%; P<0.001) compared with the control group in the 4-year follow-up. In patients with COPD, CCI ≥3 have a higher incidence of pneumonia (hazard ratio [HR] 1.61; 95% confidence interval [CI] 1.23–2.09; P<0.0001), CVD (HR 1.73; 95% CI 1.24–2.41; P=0.001), and mortality (HR 1.12; 95% CI 1.12–1.83; P=0.004). Among the major comorbidities of COPD, hyperlipidemia was associated with decreased incidence of pneumonia (HR 0.68; 95% CI 0.5–0.93; P=0.016) and mortality (HR 0.64; 95% CI 0.46–0.90; P=0.009), but was not associated with increased risk of CVD (HR 1.10; 95% CI 0.78–1.55; P=0.588).Conclusion: Our results demonstrate that COPD is associated with increased incidence of pneumonia, CVD, and mortality. In patients with COPD, higher CCI is associated with increased incidence of pneumonia, CVD, and mortality. However, COPD with hyperlipidemia is associated with decreased incidence of pneumonia and mortality. Keywords: COPD, hyperlipidemia, pneumonia, mortalityhttps://www.dovepress.com/hyperlipidemia-in-copd-is-associated-with-decreased-incidence-of-pneum-peer-reviewed-article-COPDCOPDhyperlipidemiapneumoniamortality |
| spellingShingle | Chan MC Lin CH Kou YR Hyperlipidemia in COPD is associated with decreased incidence of pneumonia and mortality: a nationwide health insurance data-based retrospective cohort study International Journal of COPD COPD hyperlipidemia pneumonia mortality |
| title | Hyperlipidemia in COPD is associated with decreased incidence of pneumonia and mortality: a nationwide health insurance data-based retrospective cohort study |
| title_full | Hyperlipidemia in COPD is associated with decreased incidence of pneumonia and mortality: a nationwide health insurance data-based retrospective cohort study |
| title_fullStr | Hyperlipidemia in COPD is associated with decreased incidence of pneumonia and mortality: a nationwide health insurance data-based retrospective cohort study |
| title_full_unstemmed | Hyperlipidemia in COPD is associated with decreased incidence of pneumonia and mortality: a nationwide health insurance data-based retrospective cohort study |
| title_short | Hyperlipidemia in COPD is associated with decreased incidence of pneumonia and mortality: a nationwide health insurance data-based retrospective cohort study |
| title_sort | hyperlipidemia in copd is associated with decreased incidence of pneumonia and mortality a nationwide health insurance data based retrospective cohort study |
| topic | COPD hyperlipidemia pneumonia mortality |
| url | https://www.dovepress.com/hyperlipidemia-in-copd-is-associated-with-decreased-incidence-of-pneum-peer-reviewed-article-COPD |
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