Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides
Herein, we report a Kumada cross-coupling reaction of benzylic sulfonamides. The scope of the transformation includes acyclic and cyclic sulfonamide precursors that cleanly produce highly substituted acyclic fragments. Preliminary data are consistent with a stereospecific mechanism that allows for a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/19/5947 |
| _version_ | 1797515953320230912 |
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| author | Kirsten A. Hewitt Claire A. Herbert Alissa C. Matus Elizabeth R. Jarvo |
| author_facet | Kirsten A. Hewitt Claire A. Herbert Alissa C. Matus Elizabeth R. Jarvo |
| author_sort | Kirsten A. Hewitt |
| collection | DOAJ |
| description | Herein, we report a Kumada cross-coupling reaction of benzylic sulfonamides. The scope of the transformation includes acyclic and cyclic sulfonamide precursors that cleanly produce highly substituted acyclic fragments. Preliminary data are consistent with a stereospecific mechanism that allows for a diastereoselective reaction. |
| first_indexed | 2024-03-10T06:54:31Z |
| format | Article |
| id | doaj.art-e3f99c77521545c2bb2247090333c28d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T06:54:31Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e3f99c77521545c2bb2247090333c28d2023-11-22T16:35:02ZengMDPI AGMolecules1420-30492021-09-012619594710.3390/molecules26195947Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic SulfonamidesKirsten A. Hewitt0Claire A. Herbert1Alissa C. Matus2Elizabeth R. Jarvo3Department of Chemistry, University of California, Irvine, CA 92697-2025, USADepartment of Chemistry, University of California, Irvine, CA 92697-2025, USADepartment of Chemistry, University of California, Irvine, CA 92697-2025, USADepartment of Chemistry, University of California, Irvine, CA 92697-2025, USAHerein, we report a Kumada cross-coupling reaction of benzylic sulfonamides. The scope of the transformation includes acyclic and cyclic sulfonamide precursors that cleanly produce highly substituted acyclic fragments. Preliminary data are consistent with a stereospecific mechanism that allows for a diastereoselective reaction.https://www.mdpi.com/1420-3049/26/19/5947cross-coupling reactionssulfonamidesnickelcatalysishydrocarbons |
| spellingShingle | Kirsten A. Hewitt Claire A. Herbert Alissa C. Matus Elizabeth R. Jarvo Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides Molecules cross-coupling reactions sulfonamides nickel catalysis hydrocarbons |
| title | Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides |
| title_full | Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides |
| title_fullStr | Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides |
| title_full_unstemmed | Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides |
| title_short | Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides |
| title_sort | nickel catalyzed kumada cross coupling reactions of benzylic sulfonamides |
| topic | cross-coupling reactions sulfonamides nickel catalysis hydrocarbons |
| url | https://www.mdpi.com/1420-3049/26/19/5947 |
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