Mitral cell spike synchrony modulated by dendrodendritic synapse location
On their long lateral dendrites, mitral cells of the olfactory bulb form dendrodendritic synapses with large populations of granule cell interneurons. The mitral-granule cell microcircuit operating through these reciprocal synapses has been implicated in inducing synchrony between mitral cells. Howe...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-01-01
|
| Series: | Frontiers in Computational Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncom.2012.00003/full |
| _version_ | 1811269771981750272 |
|---|---|
| author | Thomas S McTavish Michele eMigliore Gordon M Shepherd Michael L. Hines |
| author_facet | Thomas S McTavish Michele eMigliore Gordon M Shepherd Michael L. Hines |
| author_sort | Thomas S McTavish |
| collection | DOAJ |
| description | On their long lateral dendrites, mitral cells of the olfactory bulb form dendrodendritic synapses with large populations of granule cell interneurons. The mitral-granule cell microcircuit operating through these reciprocal synapses has been implicated in inducing synchrony between mitral cells. However, the specific mechanisms of mitral cell synchrony operating through this microcircuit are largely unknown and are complicated by the finding that distal inhibition on the lateral dendrites does not modulate mitral cell spikes. In order to gain insight into how this circuit synchronizes mitral cells within its spatial constraints, we built on a reduced circuit model of biophysically realistic multi-compartment mitral and granule cells to explore systematically the roles of dendrodendritic synapse location and mitral cell separation on synchrony. The simulations showed that mitral cells can synchronize when separated at arbitrary distances through a shared set of granule cells, but synchrony is optimally attained when shared granule cells form two balanced subsets, each subset clustered near to a soma of the mitral cell pairs. Another constraint for synchrony is that the input magnitude must be balanced. When adjusting the input magnitude driving a particular mitral cell relative to another, the mitral-granule cell circuit served to normalize spike rates of the mitral cells while inducing a phase shift or delay in the more weakly driven cell. This shift in phase is absent when the granule cells are removed from the circuit. Our results indicate that the specific distribution of dendrodendritic synaptic clusters is critical for optimal synchronization of mitral cell spikes in response to their odor input. |
| first_indexed | 2024-04-12T21:48:06Z |
| format | Article |
| id | doaj.art-e3f9b05aca29477e88720b788d218548 |
| institution | Directory Open Access Journal |
| issn | 1662-5188 |
| language | English |
| last_indexed | 2024-04-12T21:48:06Z |
| publishDate | 2012-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Computational Neuroscience |
| spelling | doaj.art-e3f9b05aca29477e88720b788d2185482022-12-22T03:15:34ZengFrontiers Media S.A.Frontiers in Computational Neuroscience1662-51882012-01-01610.3389/fncom.2012.0000315699Mitral cell spike synchrony modulated by dendrodendritic synapse locationThomas S McTavish0Michele eMigliore1Gordon M Shepherd2Michael L. Hines3Yale School of MedicineNational Research CouncilYale School of MedicineYale UniversityOn their long lateral dendrites, mitral cells of the olfactory bulb form dendrodendritic synapses with large populations of granule cell interneurons. The mitral-granule cell microcircuit operating through these reciprocal synapses has been implicated in inducing synchrony between mitral cells. However, the specific mechanisms of mitral cell synchrony operating through this microcircuit are largely unknown and are complicated by the finding that distal inhibition on the lateral dendrites does not modulate mitral cell spikes. In order to gain insight into how this circuit synchronizes mitral cells within its spatial constraints, we built on a reduced circuit model of biophysically realistic multi-compartment mitral and granule cells to explore systematically the roles of dendrodendritic synapse location and mitral cell separation on synchrony. The simulations showed that mitral cells can synchronize when separated at arbitrary distances through a shared set of granule cells, but synchrony is optimally attained when shared granule cells form two balanced subsets, each subset clustered near to a soma of the mitral cell pairs. Another constraint for synchrony is that the input magnitude must be balanced. When adjusting the input magnitude driving a particular mitral cell relative to another, the mitral-granule cell circuit served to normalize spike rates of the mitral cells while inducing a phase shift or delay in the more weakly driven cell. This shift in phase is absent when the granule cells are removed from the circuit. Our results indicate that the specific distribution of dendrodendritic synaptic clusters is critical for optimal synchronization of mitral cell spikes in response to their odor input.http://journal.frontiersin.org/Journal/10.3389/fncom.2012.00003/fullsynchronyOlfactiondendritic processingbackpropagationmitral cell |
| spellingShingle | Thomas S McTavish Michele eMigliore Gordon M Shepherd Michael L. Hines Mitral cell spike synchrony modulated by dendrodendritic synapse location Frontiers in Computational Neuroscience synchrony Olfaction dendritic processing backpropagation mitral cell |
| title | Mitral cell spike synchrony modulated by dendrodendritic synapse location |
| title_full | Mitral cell spike synchrony modulated by dendrodendritic synapse location |
| title_fullStr | Mitral cell spike synchrony modulated by dendrodendritic synapse location |
| title_full_unstemmed | Mitral cell spike synchrony modulated by dendrodendritic synapse location |
| title_short | Mitral cell spike synchrony modulated by dendrodendritic synapse location |
| title_sort | mitral cell spike synchrony modulated by dendrodendritic synapse location |
| topic | synchrony Olfaction dendritic processing backpropagation mitral cell |
| url | http://journal.frontiersin.org/Journal/10.3389/fncom.2012.00003/full |
| work_keys_str_mv | AT thomassmctavish mitralcellspikesynchronymodulatedbydendrodendriticsynapselocation AT micheleemigliore mitralcellspikesynchronymodulatedbydendrodendriticsynapselocation AT gordonmshepherd mitralcellspikesynchronymodulatedbydendrodendriticsynapselocation AT michaellhines mitralcellspikesynchronymodulatedbydendrodendriticsynapselocation |