Role of RANKL-RANK/osteoprotegerin molecular complex in bone remodeling and its immunopathologic implications
Bone remodeling is a cyclic and continuous physiological process, which ensures the conservation and renewal of the bone matrix. Osteosynthesis of the bone matrix is achieved by osteoblasts and coordinated within this complex machinery of bone remodeling with resorption of extracellular bone matrix...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Indian Journal of Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.ijem.in/article.asp?issn=2230-8210;year=2011;volume=15;issue=3;spage=175;epage=181;aulast=Kohli |
| _version_ | 1819229079441768448 |
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| author | Sarvraj Singh Kohli Virinder Singh Kohli |
| author_facet | Sarvraj Singh Kohli Virinder Singh Kohli |
| author_sort | Sarvraj Singh Kohli |
| collection | DOAJ |
| description | Bone remodeling is a cyclic and continuous physiological process, which ensures the conservation and renewal of the bone matrix. Osteosynthesis of the bone matrix is achieved by osteoblasts and coordinated within this complex machinery of bone remodeling with resorption of extracellular bone matrix performed by osteoclasts. The mismatch between the activities of osteoblasts and osteoclasts has immunopathologic implications associated with either a decrease or increase of bone mass mineral density. The balance of the trimolecular control factor complex composed of osteoprotegerin (OPG), RANKL (osteoprotegerin ligand) and RANK maintains physiologic bone remodeling. This trimolecular complex functions as receptors and ligands and belongs to the superfamily of tumor necrosis factor (TNF). This mini review highlights the complex interplay of the RANKL-RANK/OPG axis and their immunopathologic implications in clinical medicine. |
| first_indexed | 2024-12-23T11:07:28Z |
| format | Article |
| id | doaj.art-e3fb9a5831704f50819d44db9964c343 |
| institution | Directory Open Access Journal |
| issn | 2230-8210 2230-9500 |
| language | English |
| last_indexed | 2024-12-23T11:07:28Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Endocrinology and Metabolism |
| spelling | doaj.art-e3fb9a5831704f50819d44db9964c3432022-12-21T17:49:27ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102230-95002011-01-0115317518110.4103/2230-8210.83401Role of RANKL-RANK/osteoprotegerin molecular complex in bone remodeling and its immunopathologic implicationsSarvraj Singh KohliVirinder Singh KohliBone remodeling is a cyclic and continuous physiological process, which ensures the conservation and renewal of the bone matrix. Osteosynthesis of the bone matrix is achieved by osteoblasts and coordinated within this complex machinery of bone remodeling with resorption of extracellular bone matrix performed by osteoclasts. The mismatch between the activities of osteoblasts and osteoclasts has immunopathologic implications associated with either a decrease or increase of bone mass mineral density. The balance of the trimolecular control factor complex composed of osteoprotegerin (OPG), RANKL (osteoprotegerin ligand) and RANK maintains physiologic bone remodeling. This trimolecular complex functions as receptors and ligands and belongs to the superfamily of tumor necrosis factor (TNF). This mini review highlights the complex interplay of the RANKL-RANK/OPG axis and their immunopathologic implications in clinical medicine.http://www.ijem.in/article.asp?issn=2230-8210;year=2011;volume=15;issue=3;spage=175;epage=181;aulast=KohliBone metabolismbone remodelingRANK-RANKL/OPG |
| spellingShingle | Sarvraj Singh Kohli Virinder Singh Kohli Role of RANKL-RANK/osteoprotegerin molecular complex in bone remodeling and its immunopathologic implications Indian Journal of Endocrinology and Metabolism Bone metabolism bone remodeling RANK-RANKL/OPG |
| title | Role of RANKL-RANK/osteoprotegerin molecular complex in bone remodeling and its immunopathologic implications |
| title_full | Role of RANKL-RANK/osteoprotegerin molecular complex in bone remodeling and its immunopathologic implications |
| title_fullStr | Role of RANKL-RANK/osteoprotegerin molecular complex in bone remodeling and its immunopathologic implications |
| title_full_unstemmed | Role of RANKL-RANK/osteoprotegerin molecular complex in bone remodeling and its immunopathologic implications |
| title_short | Role of RANKL-RANK/osteoprotegerin molecular complex in bone remodeling and its immunopathologic implications |
| title_sort | role of rankl rank osteoprotegerin molecular complex in bone remodeling and its immunopathologic implications |
| topic | Bone metabolism bone remodeling RANK-RANKL/OPG |
| url | http://www.ijem.in/article.asp?issn=2230-8210;year=2011;volume=15;issue=3;spage=175;epage=181;aulast=Kohli |
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