HDV Can Constrain HBV Genetic Evolution in HBsAg: Implications for the Identification of Innovative Pharmacological Targets

HDV Can Constrain HBV Genetic Evolution in HBsAg: Implications for the Identification of Innovative Pharmacological Targets

Chronic HBV + HDV infection is associated with greater risk of liver fibrosis, earlier hepatic decompensation, and liver cirrhosis hepatocellular carcinoma compared to HBV mono-infection. However, to-date no direct anti-HDV drugs are available in clinical practice. Here, we identified conserved and...

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Main Authors: Luna Colagrossi, Romina Salpini, Rossana Scutari, Luca Carioti, Arianna Battisti, Lorenzo Piermatteo, Ada Bertoli, Lavinia Fabeni, Carmine Minichini, Pascale Trimoulet, Hervé Fleury, Elena Nebuloso, Maria De Cristofaro, Giuseppina Cappiello, Alberto Spanò, Vincenzo Malagnino, Terenzio Mari, Angelo Barlattani, Nerio Iapadre, Miriam Lichtner, Claudio Mastroianni, Ilaria Lenci, Caterina Pasquazzi, Giuseppe Maria De Sanctis, Alfonso Galeota Lanza, Maria Stanzione, Gianfranca Stornaiuolo, Massimo Marignani, Loredana Sarmati, Massimo Andreoni, Mario Angelico, Francesca Ceccherini-Silberstein, Carlo-Federico Perno, Nicola Coppola, Valentina Svicher
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Viruses
Subjects:
HBsAg
HDV-RNA
HDAg
Online Access:http://www.mdpi.com/1999-4915/10/7/363

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