Structure–Function Characteristics and Signaling Properties of Lipidated Peptidomimetic FPR2 Agonists: Peptoid Stereochemistry and Residues in the Vicinity of the Headgroup Affect Function
Main Authors: | Andre Holdfeldt, Sarah Line Skovbakke, Michael Gabl, Christina Nielsen, Claes Dahlgren, Henrik Franzyk, Huamei Forsman |
---|---|
Format: | Article |
Language: | English |
Published: |
American Chemical Society
2019-03-01
|
Series: | ACS Omega |
Online Access: | http://dx.doi.org/10.1021/acsomega.9b00098 |
Similar Items
-
A pepducin derived from the third intracellular loop of FPR2 is a partial agonist for direct activation of this receptor in neutrophils but a full agonist for cross-talk triggered reactivation of FPR2.
by: Michael Gabl, et al.
Published: (2014-01-01) -
Adaptive evolution of Escherichia coli to an α-peptide/β-peptoid peptidomimetic induces stable resistance.
by: Line Hein-Kristensen, et al.
Published: (2013-01-01) -
The FPR2-induced rise in cytosolic calcium in human neutrophils relies on an emptying of intracellular calcium stores and is inhibited by a gelsolin-derived PIP<sub>2</sub>-binding peptide
by: Dahlgren Claes, et al.
Published: (2010-07-01) -
Formylated MHC Class Ib Binding Peptides Activate Both Human and Mouse Neutrophils Primarily through Formyl Peptide Receptor 1.
by: Malene Winther, et al.
Published: (2016-01-01) -
Formyl peptide derived lipopeptides disclose differences between the receptors in mouse and men and call the pepducin concept in question.
by: Malene Winther, et al.
Published: (2017-01-01)