Endobronchial cryptococcosis with bronchial stenosis in a patient with severe asthma treated with inhaled corticosteroids: A case report
Abstract Cryptococcosis typically manifests as pulmonary lesions, with endobronchial lesions occurring rarely. Inhaled corticosteroids (ICS) may be a risk factor for cryptococcosis of the larynx but not of the bronchi. Here, we report a case involving a 73‐year‐old Japanese man who developed endobro...
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Respirology Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rcr2.1245 |
| _version_ | 1827636103815888896 |
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| author | Jun Sasaki Takashi Kinoshita Misa Sudou Takayuki Horii Reiko Takaki Masahiro Mitsuoka Masaki Tominaga Tomotaka Kawayama Tomoaki Hoshino |
| author_facet | Jun Sasaki Takashi Kinoshita Misa Sudou Takayuki Horii Reiko Takaki Masahiro Mitsuoka Masaki Tominaga Tomotaka Kawayama Tomoaki Hoshino |
| author_sort | Jun Sasaki |
| collection | DOAJ |
| description | Abstract Cryptococcosis typically manifests as pulmonary lesions, with endobronchial lesions occurring rarely. Inhaled corticosteroids (ICS) may be a risk factor for cryptococcosis of the larynx but not of the bronchi. Here, we report a case involving a 73‐year‐old Japanese man who developed endobronchial cryptococcosis during ICS treatment for asthma. Chest computed tomography showed right mainstem bronchial stenosis and asthma control worsening when he received adequate asthma treatments. Bronchoscopy revealed multiple elevated lesions with white slough from the trachea to the right mainstem bronchus and the right mainstem bronchus lumen entrance narrowing. Bronchial lavage culture revealed Cryptococcus neoformans. Combination treatment with the antifungal agent, mepolizumab, and bronchodilation surgery successfully controlled cryptococcosis and asthma. Attention should be paid to central airway lesions during ICS treatment for uncontrolled asthma. |
| first_indexed | 2024-03-09T15:36:31Z |
| format | Article |
| id | doaj.art-e3fde4db508641d799300e7c272730a7 |
| institution | Directory Open Access Journal |
| issn | 2051-3380 |
| language | English |
| last_indexed | 2024-03-09T15:36:31Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj.art-e3fde4db508641d799300e7c272730a72023-11-26T04:58:30ZengWileyRespirology Case Reports2051-33802023-12-011112n/an/a10.1002/rcr2.1245Endobronchial cryptococcosis with bronchial stenosis in a patient with severe asthma treated with inhaled corticosteroids: A case reportJun Sasaki0Takashi Kinoshita1Misa Sudou2Takayuki Horii3Reiko Takaki4Masahiro Mitsuoka5Masaki Tominaga6Tomotaka Kawayama7Tomoaki Hoshino8Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine Kurume University School of Medicine Kurume JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine Kurume University School of Medicine Kurume JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine Kurume University School of Medicine Kurume JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine Kurume University School of Medicine Kurume JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine Kurume University School of Medicine Kurume JapanDepartment of Surgery Kurume University School of Medicine Kurume JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine Kurume University School of Medicine Kurume JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine Kurume University School of Medicine Kurume JapanDivision of Respirology, Neurology, and Rheumatology, Department of Internal Medicine Kurume University School of Medicine Kurume JapanAbstract Cryptococcosis typically manifests as pulmonary lesions, with endobronchial lesions occurring rarely. Inhaled corticosteroids (ICS) may be a risk factor for cryptococcosis of the larynx but not of the bronchi. Here, we report a case involving a 73‐year‐old Japanese man who developed endobronchial cryptococcosis during ICS treatment for asthma. Chest computed tomography showed right mainstem bronchial stenosis and asthma control worsening when he received adequate asthma treatments. Bronchoscopy revealed multiple elevated lesions with white slough from the trachea to the right mainstem bronchus and the right mainstem bronchus lumen entrance narrowing. Bronchial lavage culture revealed Cryptococcus neoformans. Combination treatment with the antifungal agent, mepolizumab, and bronchodilation surgery successfully controlled cryptococcosis and asthma. Attention should be paid to central airway lesions during ICS treatment for uncontrolled asthma.https://doi.org/10.1002/rcr2.1245asthmabronchial stenosiscryptococcosisendobronchial cryptococcosisinhaled corticosteroid |
| spellingShingle | Jun Sasaki Takashi Kinoshita Misa Sudou Takayuki Horii Reiko Takaki Masahiro Mitsuoka Masaki Tominaga Tomotaka Kawayama Tomoaki Hoshino Endobronchial cryptococcosis with bronchial stenosis in a patient with severe asthma treated with inhaled corticosteroids: A case report Respirology Case Reports asthma bronchial stenosis cryptococcosis endobronchial cryptococcosis inhaled corticosteroid |
| title | Endobronchial cryptococcosis with bronchial stenosis in a patient with severe asthma treated with inhaled corticosteroids: A case report |
| title_full | Endobronchial cryptococcosis with bronchial stenosis in a patient with severe asthma treated with inhaled corticosteroids: A case report |
| title_fullStr | Endobronchial cryptococcosis with bronchial stenosis in a patient with severe asthma treated with inhaled corticosteroids: A case report |
| title_full_unstemmed | Endobronchial cryptococcosis with bronchial stenosis in a patient with severe asthma treated with inhaled corticosteroids: A case report |
| title_short | Endobronchial cryptococcosis with bronchial stenosis in a patient with severe asthma treated with inhaled corticosteroids: A case report |
| title_sort | endobronchial cryptococcosis with bronchial stenosis in a patient with severe asthma treated with inhaled corticosteroids a case report |
| topic | asthma bronchial stenosis cryptococcosis endobronchial cryptococcosis inhaled corticosteroid |
| url | https://doi.org/10.1002/rcr2.1245 |
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