Preservation of Rat Aortic Tissue Transplant with Green Tea Polyphenols

Green tea polyphenols have recently attracted medical attention as bioactive agents with anticancer, antimicrobial, and antiviral effects. We discovered their new usage as preservative agents for tissue transplants. We preserved rat aortas in a DMEM solution containing polyphenols extracted from gre...

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Main Authors: S.-H. Hyon, D.-H. Kim, W. Cui, K. Matsumura, J.-Y. Kim, S. Tsutsumi
Format: Article
Language:English
Published: SAGE Publishing 2006-11-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/000000006783981422
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author S.-H. Hyon
D.-H. Kim
W. Cui
K. Matsumura
J.-Y. Kim
S. Tsutsumi
author_facet S.-H. Hyon
D.-H. Kim
W. Cui
K. Matsumura
J.-Y. Kim
S. Tsutsumi
author_sort S.-H. Hyon
collection DOAJ
description Green tea polyphenols have recently attracted medical attention as bioactive agents with anticancer, antimicrobial, and antiviral effects. We discovered their new usage as preservative agents for tissue transplants. We preserved rat aortas in a DMEM solution containing polyphenols extracted from green tea leaves. The preserved aortas retained original structures and mechanical strength, and were devoid of any undesirable cell secretions for over a month under physiological conditions. In addition, aortas from Lewis rats preserved for a month and transplanted to allogenic ACI rats completely avoided rejection by the host, suggesting that the polyphenols have immunosuppressive actions on the aortic tissues. From these results, we conclude that polyphenol treatment of aortic tissue transplant can maintain its viability for extended periods of time either before or after transplantation, and the method can be applicable to other transplantation situations.
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spelling doaj.art-e3fe5d1d5c53408c9456fafa0c1599552022-12-21T18:57:35ZengSAGE PublishingCell Transplantation0963-68971555-38922006-11-011510.3727/000000006783981422Preservation of Rat Aortic Tissue Transplant with Green Tea PolyphenolsS.-H. Hyon0D.-H. Kim1W. Cui2K. Matsumura3J.-Y. Kim4S. Tsutsumi5Institute for Frontier Medical Sciences, Kyoto University, Kyoto, JapanInstitute for Frontier Medical Sciences, Kyoto University, Kyoto, JapanInstitute for Frontier Medical Sciences, Kyoto University, Kyoto, JapanInstitute for Frontier Medical Sciences, Kyoto University, Kyoto, JapanInstitute for Frontier Medical Sciences, Kyoto University, Kyoto, JapanInstitute for Frontier Medical Sciences, Kyoto University, Kyoto, JapanGreen tea polyphenols have recently attracted medical attention as bioactive agents with anticancer, antimicrobial, and antiviral effects. We discovered their new usage as preservative agents for tissue transplants. We preserved rat aortas in a DMEM solution containing polyphenols extracted from green tea leaves. The preserved aortas retained original structures and mechanical strength, and were devoid of any undesirable cell secretions for over a month under physiological conditions. In addition, aortas from Lewis rats preserved for a month and transplanted to allogenic ACI rats completely avoided rejection by the host, suggesting that the polyphenols have immunosuppressive actions on the aortic tissues. From these results, we conclude that polyphenol treatment of aortic tissue transplant can maintain its viability for extended periods of time either before or after transplantation, and the method can be applicable to other transplantation situations.https://doi.org/10.3727/000000006783981422
spellingShingle S.-H. Hyon
D.-H. Kim
W. Cui
K. Matsumura
J.-Y. Kim
S. Tsutsumi
Preservation of Rat Aortic Tissue Transplant with Green Tea Polyphenols
Cell Transplantation
title Preservation of Rat Aortic Tissue Transplant with Green Tea Polyphenols
title_full Preservation of Rat Aortic Tissue Transplant with Green Tea Polyphenols
title_fullStr Preservation of Rat Aortic Tissue Transplant with Green Tea Polyphenols
title_full_unstemmed Preservation of Rat Aortic Tissue Transplant with Green Tea Polyphenols
title_short Preservation of Rat Aortic Tissue Transplant with Green Tea Polyphenols
title_sort preservation of rat aortic tissue transplant with green tea polyphenols
url https://doi.org/10.3727/000000006783981422
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