Mesenchymal stem cells: a promising way in therapies of graft-versus-host disease
Abstract It is well acknowledged that allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for numerous malignant blood diseases, which has also been applied to autoimmune diseases for more than a decade. Whereas graft-versus-host disease (GVHD) occurs after allog...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-04-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12935-020-01193-z |
| _version_ | 1811198417173479424 |
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| author | Xinyi Zhou Nan Jin Fei Wang Baoan Chen |
| author_facet | Xinyi Zhou Nan Jin Fei Wang Baoan Chen |
| author_sort | Xinyi Zhou |
| collection | DOAJ |
| description | Abstract It is well acknowledged that allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for numerous malignant blood diseases, which has also been applied to autoimmune diseases for more than a decade. Whereas graft-versus-host disease (GVHD) occurs after allogeneic hematopoietic stem cell transplantation (allo-HSCT) as a common serious complication, seriously affecting the efficacy of transplantation. Mesenchymal stem cells (MSCs) derived from a wealth of sources can easily isolate and expand with low immunogenicity. MSCs also have paracrine and immune regulatory functions, leading to a broad application prospect in treatment and tissue engineering. This review focuses on immunoregulatory function of MSCs, factors affecting mesenchymal stem cells to exert immunosuppressive effects, clinical application of MSCs in GVHD and researches on MSC-derived extracellular vesicles (EVs). The latest research progress on MSC in related fields is reviewed as well. The relevant literature from PubMed databases is reviewed in this article. |
| first_indexed | 2024-04-12T01:31:15Z |
| format | Article |
| id | doaj.art-e40177e1af49412a9554b8064c0a3a0b |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-12T01:31:15Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-e40177e1af49412a9554b8064c0a3a0b2022-12-22T03:53:29ZengBMCCancer Cell International1475-28672020-04-0120111110.1186/s12935-020-01193-zMesenchymal stem cells: a promising way in therapies of graft-versus-host diseaseXinyi Zhou0Nan Jin1Fei Wang2Baoan Chen3Department of Hematology and Oncology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast UniversityDepartment of Hematology and Oncology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast UniversityDepartment of Hematology and Oncology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast UniversityDepartment of Hematology and Oncology (Key Department of Jiangsu Medicine), Zhongda Hospital, Medical School, Southeast UniversityAbstract It is well acknowledged that allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for numerous malignant blood diseases, which has also been applied to autoimmune diseases for more than a decade. Whereas graft-versus-host disease (GVHD) occurs after allogeneic hematopoietic stem cell transplantation (allo-HSCT) as a common serious complication, seriously affecting the efficacy of transplantation. Mesenchymal stem cells (MSCs) derived from a wealth of sources can easily isolate and expand with low immunogenicity. MSCs also have paracrine and immune regulatory functions, leading to a broad application prospect in treatment and tissue engineering. This review focuses on immunoregulatory function of MSCs, factors affecting mesenchymal stem cells to exert immunosuppressive effects, clinical application of MSCs in GVHD and researches on MSC-derived extracellular vesicles (EVs). The latest research progress on MSC in related fields is reviewed as well. The relevant literature from PubMed databases is reviewed in this article.http://link.springer.com/article/10.1186/s12935-020-01193-zAllogeneic hematopoietic stem cell transplantation (allo-HSCT)Graft-versus-host disease (GVHD)Mesenchymal stem cells (MSCs)Immunoregulatory functionMSC-derived extracellular vesicles (EVs) |
| spellingShingle | Xinyi Zhou Nan Jin Fei Wang Baoan Chen Mesenchymal stem cells: a promising way in therapies of graft-versus-host disease Cancer Cell International Allogeneic hematopoietic stem cell transplantation (allo-HSCT) Graft-versus-host disease (GVHD) Mesenchymal stem cells (MSCs) Immunoregulatory function MSC-derived extracellular vesicles (EVs) |
| title | Mesenchymal stem cells: a promising way in therapies of graft-versus-host disease |
| title_full | Mesenchymal stem cells: a promising way in therapies of graft-versus-host disease |
| title_fullStr | Mesenchymal stem cells: a promising way in therapies of graft-versus-host disease |
| title_full_unstemmed | Mesenchymal stem cells: a promising way in therapies of graft-versus-host disease |
| title_short | Mesenchymal stem cells: a promising way in therapies of graft-versus-host disease |
| title_sort | mesenchymal stem cells a promising way in therapies of graft versus host disease |
| topic | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) Graft-versus-host disease (GVHD) Mesenchymal stem cells (MSCs) Immunoregulatory function MSC-derived extracellular vesicles (EVs) |
| url | http://link.springer.com/article/10.1186/s12935-020-01193-z |
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