Impact of traditional risk factors for the outcomes of atrial fibrillation across race and ethnicity and sex groups
Background: Although traditional risk factors for atrial fibrillation (AF) and its outcomes are established in whites, their role in the pathogenesis of AF across race-ethnicity and both sexes remain unclear. Cohort studies have consistently shown worse AF-related outcomes in these groups. The objec...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906720301172 |
| _version_ | 1818188614453952512 |
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| author | Timothy Shih Karina Ledezma Mark McCauley Jalees Rehman William L. Galanter Dawood Darbar |
| author_facet | Timothy Shih Karina Ledezma Mark McCauley Jalees Rehman William L. Galanter Dawood Darbar |
| author_sort | Timothy Shih |
| collection | DOAJ |
| description | Background: Although traditional risk factors for atrial fibrillation (AF) and its outcomes are established in whites, their role in the pathogenesis of AF across race-ethnicity and both sexes remain unclear. Cohort studies have consistently shown worse AF-related outcomes in these groups. The objective of this study was to determine the role played by race- and sex-specific risk factors in AF outcomes in non-Hispanic blacks (NHBs), Hispanics/Latinos (H/Ls), and non-Hispanic whites (NHWs). Methods: Using electronic health records (EHR), 3607 patients with an ICD-9 code for AF were identified over a 7-year period. Risk factors were identified from ICD to 9 CM claims data: hypertension (HTN), type 2 diabetes mellitus (T2DM), stroke/transient ischemic attack (TIA), smoking, chronic obstructive pulmonary disease (COPD), coronary artery disease (CAD), peripheral arterial disease (PAD) and obstructive sleep apnea (OSA). Multivariate analysis of variance was used to compare the incidence of AF risk factors. Results: NHBs and H/Ls with AF experienced more stroke than NHWs (27% and 24% vs. 19% P < 0.01). Females had less HTN (48.4% vs 51.6% [males], P = 0.0002), CAD (47.4% vs 55.7% [males], P = 0.02), and smoking rates (38.2% vs 61.8% [males], P < 0.0001) but higher stroke rates (25.9% [female] vs 21.8% [males], P < 0.0001). Age-adjusted risk factors for stroke varied markedly across race-ethnicity and sex. Conclusions: We identified differences in risk factors for AF and stroke across race-ethnicity and sex. The findings of our study are hypothesis generating and should be used to direct future studies. |
| first_indexed | 2024-12-11T23:29:43Z |
| format | Article |
| id | doaj.art-e401d82d5ea949d0a505bfe35d95ce9d |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-12-11T23:29:43Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-e401d82d5ea949d0a505bfe35d95ce9d2022-12-22T00:46:04ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672020-06-0128100538Impact of traditional risk factors for the outcomes of atrial fibrillation across race and ethnicity and sex groupsTimothy Shih0Karina Ledezma1Mark McCauley2Jalees Rehman3William L. Galanter4Dawood Darbar5Departments of Medicine, University of Illinois at Chicago, USADepartments of Medicine, University of Illinois at Chicago, USADepartments of Medicine, University of Illinois at Chicago, USADepartments of Medicine, University of Illinois at Chicago, USA; Departments of Pharmacology, University of Illinois at Chicago, USADepartments of Medicine, University of Illinois at Chicago, USADepartments of Medicine, University of Illinois at Chicago, USA; Departments of Pharmacology, University of Illinois at Chicago, USA; Department of Medicine, Jesse Brown Veterans Administration, Chicago, IL, USA; Corresponding author: Division of Cardiology, 840 S. Wood St., 920S (MC 715), University of Illinois at Chicago, Chicago, IL 60612, USABackground: Although traditional risk factors for atrial fibrillation (AF) and its outcomes are established in whites, their role in the pathogenesis of AF across race-ethnicity and both sexes remain unclear. Cohort studies have consistently shown worse AF-related outcomes in these groups. The objective of this study was to determine the role played by race- and sex-specific risk factors in AF outcomes in non-Hispanic blacks (NHBs), Hispanics/Latinos (H/Ls), and non-Hispanic whites (NHWs). Methods: Using electronic health records (EHR), 3607 patients with an ICD-9 code for AF were identified over a 7-year period. Risk factors were identified from ICD to 9 CM claims data: hypertension (HTN), type 2 diabetes mellitus (T2DM), stroke/transient ischemic attack (TIA), smoking, chronic obstructive pulmonary disease (COPD), coronary artery disease (CAD), peripheral arterial disease (PAD) and obstructive sleep apnea (OSA). Multivariate analysis of variance was used to compare the incidence of AF risk factors. Results: NHBs and H/Ls with AF experienced more stroke than NHWs (27% and 24% vs. 19% P < 0.01). Females had less HTN (48.4% vs 51.6% [males], P = 0.0002), CAD (47.4% vs 55.7% [males], P = 0.02), and smoking rates (38.2% vs 61.8% [males], P < 0.0001) but higher stroke rates (25.9% [female] vs 21.8% [males], P < 0.0001). Age-adjusted risk factors for stroke varied markedly across race-ethnicity and sex. Conclusions: We identified differences in risk factors for AF and stroke across race-ethnicity and sex. The findings of our study are hypothesis generating and should be used to direct future studies.http://www.sciencedirect.com/science/article/pii/S2352906720301172Atrial fibrillationRisk factorsRacial disparitiesStrokeSex disparities |
| spellingShingle | Timothy Shih Karina Ledezma Mark McCauley Jalees Rehman William L. Galanter Dawood Darbar Impact of traditional risk factors for the outcomes of atrial fibrillation across race and ethnicity and sex groups International Journal of Cardiology: Heart & Vasculature Atrial fibrillation Risk factors Racial disparities Stroke Sex disparities |
| title | Impact of traditional risk factors for the outcomes of atrial fibrillation across race and ethnicity and sex groups |
| title_full | Impact of traditional risk factors for the outcomes of atrial fibrillation across race and ethnicity and sex groups |
| title_fullStr | Impact of traditional risk factors for the outcomes of atrial fibrillation across race and ethnicity and sex groups |
| title_full_unstemmed | Impact of traditional risk factors for the outcomes of atrial fibrillation across race and ethnicity and sex groups |
| title_short | Impact of traditional risk factors for the outcomes of atrial fibrillation across race and ethnicity and sex groups |
| title_sort | impact of traditional risk factors for the outcomes of atrial fibrillation across race and ethnicity and sex groups |
| topic | Atrial fibrillation Risk factors Racial disparities Stroke Sex disparities |
| url | http://www.sciencedirect.com/science/article/pii/S2352906720301172 |
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