Comparative Efficacy of Botulinum Toxin in Salivary Glands vs. Oromotor Therapy in the Management of Sialorrhea in Cerebral Palsy Impact on Sleep Quality
AimsThe aim of this study was to compare the effects of intraglandular abobotuliniumtoxinA application and oromotor therapy in the management of sialorrhea in patients with cerebral palsy and its effect on sleep quality.MethodsA comparative study (n = 134), mean age 7.1 years (± 3.9 years) was perfo...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Rehabilitation Sciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fresc.2022.875235/full |
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| author | Juan Francisco Marquez-Vazquez María Elena Arellano-Saldaña Karla Nayeli Rojas-Martinez Paul Carrillo-Mora |
| author_facet | Juan Francisco Marquez-Vazquez María Elena Arellano-Saldaña Karla Nayeli Rojas-Martinez Paul Carrillo-Mora |
| author_sort | Juan Francisco Marquez-Vazquez |
| collection | DOAJ |
| description | AimsThe aim of this study was to compare the effects of intraglandular abobotuliniumtoxinA application and oromotor therapy in the management of sialorrhea in patients with cerebral palsy and its effect on sleep quality.MethodsA comparative study (n = 134), mean age 7.1 years (± 3.9 years) was performed in pediatric patients, between the efficacy of abobotuliniumtoxinA in salivary glands and oromotor therapy (JT), with a control group receiving exclusive oromotor therapy (EOMT). Demographic variables, as well as Gross Motor Function Classification System (GMFCS), Drooling Severity and Frequency Scale (DSFS), Sleep Disturbance Scale for Children (SDSC) and Eating and Drinking Ability Classification System (EDACS) were analyzed in 134 patients considering two measurements 6 months apart. Statistical analysis was developed between both groups.ResultsThe greatest improvement in safety and efficacy of swallowing were those in the JT group with initial levels of EDACS IV and V. Both therapies result in favorable changes of all subscales means of SDSC, with joint therapy showing the greater benefit (p = 0.003) over EOMT (p = 0.06), especially for Sleep Breathing Disorders and Disorders of initiating and maintaining sleep (p < 0.01 vs. p = 0.07). No major adverse effects were found, only those expected from the application of the toxin, such as pain, mild, and transient local inflammation.InterpretationA correlation between frequency and intensity of sialorrhea, with the frequency of sleep disorders and dysphagia was found. Conventional EOMT proved to be useful, improving the safety and efficacy of swallowing, sialorrhea and sleep disorder, however it can be enhanced with the application of abobotuliniumtoxinA. |
| first_indexed | 2024-04-11T01:50:21Z |
| format | Article |
| id | doaj.art-e401eb1826514512ba18b6900f14b55f |
| institution | Directory Open Access Journal |
| issn | 2673-6861 |
| language | English |
| last_indexed | 2024-04-11T01:50:21Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Rehabilitation Sciences |
| spelling | doaj.art-e401eb1826514512ba18b6900f14b55f2023-01-03T06:55:19ZengFrontiers Media S.A.Frontiers in Rehabilitation Sciences2673-68612022-06-01310.3389/fresc.2022.875235875235Comparative Efficacy of Botulinum Toxin in Salivary Glands vs. Oromotor Therapy in the Management of Sialorrhea in Cerebral Palsy Impact on Sleep QualityJuan Francisco Marquez-Vazquez0María Elena Arellano-Saldaña1Karla Nayeli Rojas-Martinez2Paul Carrillo-Mora3Master and Doctorate Division, Instituto Nacional de Rehabilitación LGII, Tlalpan, MéxicoPediatric Rehabilitation Service, Instituto Nacional de Rehabilitación LGII, Tlalpan, MéxicoPediatric Rehabilitation Service, Instituto Nacional de Rehabilitación LGII, Tlalpan, MéxicoNeuroscience Research Division, Instituto Nacional de Rehabilitación LGII, Tlalpan, MéxicoAimsThe aim of this study was to compare the effects of intraglandular abobotuliniumtoxinA application and oromotor therapy in the management of sialorrhea in patients with cerebral palsy and its effect on sleep quality.MethodsA comparative study (n = 134), mean age 7.1 years (± 3.9 years) was performed in pediatric patients, between the efficacy of abobotuliniumtoxinA in salivary glands and oromotor therapy (JT), with a control group receiving exclusive oromotor therapy (EOMT). Demographic variables, as well as Gross Motor Function Classification System (GMFCS), Drooling Severity and Frequency Scale (DSFS), Sleep Disturbance Scale for Children (SDSC) and Eating and Drinking Ability Classification System (EDACS) were analyzed in 134 patients considering two measurements 6 months apart. Statistical analysis was developed between both groups.ResultsThe greatest improvement in safety and efficacy of swallowing were those in the JT group with initial levels of EDACS IV and V. Both therapies result in favorable changes of all subscales means of SDSC, with joint therapy showing the greater benefit (p = 0.003) over EOMT (p = 0.06), especially for Sleep Breathing Disorders and Disorders of initiating and maintaining sleep (p < 0.01 vs. p = 0.07). No major adverse effects were found, only those expected from the application of the toxin, such as pain, mild, and transient local inflammation.InterpretationA correlation between frequency and intensity of sialorrhea, with the frequency of sleep disorders and dysphagia was found. Conventional EOMT proved to be useful, improving the safety and efficacy of swallowing, sialorrhea and sleep disorder, however it can be enhanced with the application of abobotuliniumtoxinA.https://www.frontiersin.org/articles/10.3389/fresc.2022.875235/fullcerebral palsybotulinum toxin type Asleep disorderssialorrheaoromotor assessment |
| spellingShingle | Juan Francisco Marquez-Vazquez María Elena Arellano-Saldaña Karla Nayeli Rojas-Martinez Paul Carrillo-Mora Comparative Efficacy of Botulinum Toxin in Salivary Glands vs. Oromotor Therapy in the Management of Sialorrhea in Cerebral Palsy Impact on Sleep Quality Frontiers in Rehabilitation Sciences cerebral palsy botulinum toxin type A sleep disorders sialorrhea oromotor assessment |
| title | Comparative Efficacy of Botulinum Toxin in Salivary Glands vs. Oromotor Therapy in the Management of Sialorrhea in Cerebral Palsy Impact on Sleep Quality |
| title_full | Comparative Efficacy of Botulinum Toxin in Salivary Glands vs. Oromotor Therapy in the Management of Sialorrhea in Cerebral Palsy Impact on Sleep Quality |
| title_fullStr | Comparative Efficacy of Botulinum Toxin in Salivary Glands vs. Oromotor Therapy in the Management of Sialorrhea in Cerebral Palsy Impact on Sleep Quality |
| title_full_unstemmed | Comparative Efficacy of Botulinum Toxin in Salivary Glands vs. Oromotor Therapy in the Management of Sialorrhea in Cerebral Palsy Impact on Sleep Quality |
| title_short | Comparative Efficacy of Botulinum Toxin in Salivary Glands vs. Oromotor Therapy in the Management of Sialorrhea in Cerebral Palsy Impact on Sleep Quality |
| title_sort | comparative efficacy of botulinum toxin in salivary glands vs oromotor therapy in the management of sialorrhea in cerebral palsy impact on sleep quality |
| topic | cerebral palsy botulinum toxin type A sleep disorders sialorrhea oromotor assessment |
| url | https://www.frontiersin.org/articles/10.3389/fresc.2022.875235/full |
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