Short-term outcomes and intermediate-term follow-up of Helicobacter pylori infection treatment for naïve patients: a retrospective observational study
Objectives To explore the outcomes of Helicobacter pylori infection treatments for naïve patients in the real-world settings.Design A retrospective observational study.Setting Single tertiary level academic hospital in China.Participants We identified patients initially receiving quadruple therapy f...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2022-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/12/9/e062096.full |
| _version_ | 1811182462809669632 |
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| author | Yan Li Jun Ye Yu Xiang Yujing Wang Oulan Liao Yaoyi Wu Qin Du |
| author_facet | Yan Li Jun Ye Yu Xiang Yujing Wang Oulan Liao Yaoyi Wu Qin Du |
| author_sort | Yan Li |
| collection | DOAJ |
| description | Objectives To explore the outcomes of Helicobacter pylori infection treatments for naïve patients in the real-world settings.Design A retrospective observational study.Setting Single tertiary level academic hospital in China.Participants We identified patients initially receiving quadruple therapy for H. pylori infection from 2017 to 2020 in whom eradication was confirmed (n=23 470).Primary outcome Efficacy of different initial H. pylori infection treatments.Secondary outcome Results of urea breath test (UBT) after H. pylori eradication.Results Among 23 470 patients who received initial H. pylori treatment, 21 285 (90.7%) were treated with amoxicillin-based regimens. The median age of the patients decreased from 2017 to 2020 (45.0 vs 39.0, p<0.0001). The main treatments were therapies containing amoxicillin and furazolidone, which had an eradication rate of 87.6% (14 707/16 784); those containing amoxicillin and clarithromycin had an eradication rate of 85.5% (3577/4182). The date of treatment, age, antibiotic regimen and duration of treatment showed correlations with the failure of H. pylori eradication in a multivariable logistic regression analysis. Finally, positive UBT results after eradication clustered around the cut-off value, in both the 13C-UBT and 14C-UBT.Conclusions The major H. pylori infection treatments for naïve patients were those containing amoxicillin and furazolidone, which offered the highest eradication rate. The date of treatment, age, antibiotic regimen and duration of treatment were risk factors for the failure of H. pylori eradication. Additionally, positive UBT results after eradication clustered around the cut-off value. |
| first_indexed | 2024-04-11T09:32:47Z |
| format | Article |
| id | doaj.art-e402e4b045e347f1af9ac9fa512b5dd4 |
| institution | Directory Open Access Journal |
| issn | 2044-6055 |
| language | English |
| last_indexed | 2024-04-11T09:32:47Z |
| publishDate | 2022-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj.art-e402e4b045e347f1af9ac9fa512b5dd42022-12-22T04:31:49ZengBMJ Publishing GroupBMJ Open2044-60552022-09-0112910.1136/bmjopen-2022-062096Short-term outcomes and intermediate-term follow-up of Helicobacter pylori infection treatment for naïve patients: a retrospective observational studyYan Li0Jun Ye1Yu Xiang2Yujing Wang3Oulan Liao4Yaoyi Wu5Qin Du6Department of Gastroenterology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, ChinaDepartment of Gastroenterology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, ChinaDepartment of Gastroenterology, Huzhou Central Hospital, Huzhou, Zhejiang Province, ChinaDepartment of Gastroenterology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, ChinaDepartment of Gastroenterology, The Fourth Affiliated Hospital Zhejiang University School of Medicine, Yiwu, Zhejiang, ChinaDepartment of Gastroenterology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, ChinaDepartment of Gastroenterology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, Zhejiang, ChinaObjectives To explore the outcomes of Helicobacter pylori infection treatments for naïve patients in the real-world settings.Design A retrospective observational study.Setting Single tertiary level academic hospital in China.Participants We identified patients initially receiving quadruple therapy for H. pylori infection from 2017 to 2020 in whom eradication was confirmed (n=23 470).Primary outcome Efficacy of different initial H. pylori infection treatments.Secondary outcome Results of urea breath test (UBT) after H. pylori eradication.Results Among 23 470 patients who received initial H. pylori treatment, 21 285 (90.7%) were treated with amoxicillin-based regimens. The median age of the patients decreased from 2017 to 2020 (45.0 vs 39.0, p<0.0001). The main treatments were therapies containing amoxicillin and furazolidone, which had an eradication rate of 87.6% (14 707/16 784); those containing amoxicillin and clarithromycin had an eradication rate of 85.5% (3577/4182). The date of treatment, age, antibiotic regimen and duration of treatment showed correlations with the failure of H. pylori eradication in a multivariable logistic regression analysis. Finally, positive UBT results after eradication clustered around the cut-off value, in both the 13C-UBT and 14C-UBT.Conclusions The major H. pylori infection treatments for naïve patients were those containing amoxicillin and furazolidone, which offered the highest eradication rate. The date of treatment, age, antibiotic regimen and duration of treatment were risk factors for the failure of H. pylori eradication. Additionally, positive UBT results after eradication clustered around the cut-off value.https://bmjopen.bmj.com/content/12/9/e062096.full |
| spellingShingle | Yan Li Jun Ye Yu Xiang Yujing Wang Oulan Liao Yaoyi Wu Qin Du Short-term outcomes and intermediate-term follow-up of Helicobacter pylori infection treatment for naïve patients: a retrospective observational study BMJ Open |
| title | Short-term outcomes and intermediate-term follow-up of Helicobacter pylori infection treatment for naïve patients: a retrospective observational study |
| title_full | Short-term outcomes and intermediate-term follow-up of Helicobacter pylori infection treatment for naïve patients: a retrospective observational study |
| title_fullStr | Short-term outcomes and intermediate-term follow-up of Helicobacter pylori infection treatment for naïve patients: a retrospective observational study |
| title_full_unstemmed | Short-term outcomes and intermediate-term follow-up of Helicobacter pylori infection treatment for naïve patients: a retrospective observational study |
| title_short | Short-term outcomes and intermediate-term follow-up of Helicobacter pylori infection treatment for naïve patients: a retrospective observational study |
| title_sort | short term outcomes and intermediate term follow up of helicobacter pylori infection treatment for naive patients a retrospective observational study |
| url | https://bmjopen.bmj.com/content/12/9/e062096.full |
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