Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil
Leiomyomas (LMs) are the most frequent uterine benign tumors, representing the leading cause of hysterectomy indications worldwide. They are highly associated with women’s reproductive complications, and endocrine disruptors may influence their etiology. In this sense, air pollution represents a rel...
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/3/2431 |
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| author | Laura Gonzalez dos Anjos Bruna Cristine de Almeida Edmund Chada Baracat Ayman Al-Hendy Qiwei Yang Katia Candido Carvalho |
| author_facet | Laura Gonzalez dos Anjos Bruna Cristine de Almeida Edmund Chada Baracat Ayman Al-Hendy Qiwei Yang Katia Candido Carvalho |
| author_sort | Laura Gonzalez dos Anjos |
| collection | DOAJ |
| description | Leiomyomas (LMs) are the most frequent uterine benign tumors, representing the leading cause of hysterectomy indications worldwide. They are highly associated with women’s reproductive complications, and endocrine disruptors may influence their etiology. In this sense, air pollution represents a relevant hormonal disruptor that acts on key signaling pathways, resulting in tumor development and infertility. Our goal was to evaluate submucosal LM samples from patients living in the metropolitan and Sao Paulo city regions, focusing on genes involved in tumor development and infertility features. Twenty-four patients were selected based on their region of residence and clinical information availability. Several genes were differentially expressed between women living in metropolitan areas and Sao Paulo city. Significant associations were observed between <i>BCL-2</i>, <i>DVL1</i>, <i>FGFR3</i>, and <i>WNT5b</i> downregulation and contraceptive use in the samples from women living in Sao Paulo city. <i>ESR1</i> and <i>HHAT</i> downregulation was associated with ethnicity. <i>WNT5b</i> and <i>GREM</i> were associated with LM treatment and related pathologies, respectively. In the samples from women living in other cities of the metropolitan region, abortion occurrence was associated with <i>BMP4</i> upregulation. Although further studies may be necessary, our results showed that air pollution exposure influences the expression of genes related to LM development and female reproductive features. |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:42:20Z |
| publishDate | 2023-01-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e4051c628dd8443ca0668ab8e40a59462023-11-16T16:57:06ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243243110.3390/ijms24032431Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, BrazilLaura Gonzalez dos Anjos0Bruna Cristine de Almeida1Edmund Chada Baracat2Ayman Al-Hendy3Qiwei Yang4Katia Candido Carvalho5Laboratório de Ginecologia Estrutural e Molecular (LIM 58), Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), São Paulo 05403-010, BrazilLaboratório de Ginecologia Estrutural e Molecular (LIM 58), Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), São Paulo 05403-010, BrazilLaboratório de Ginecologia Estrutural e Molecular (LIM 58), Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), São Paulo 05403-010, BrazilDepartment of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USADepartment of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USALaboratório de Ginecologia Estrutural e Molecular (LIM 58), Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo (HCFMUSP), São Paulo 05403-010, BrazilLeiomyomas (LMs) are the most frequent uterine benign tumors, representing the leading cause of hysterectomy indications worldwide. They are highly associated with women’s reproductive complications, and endocrine disruptors may influence their etiology. In this sense, air pollution represents a relevant hormonal disruptor that acts on key signaling pathways, resulting in tumor development and infertility. Our goal was to evaluate submucosal LM samples from patients living in the metropolitan and Sao Paulo city regions, focusing on genes involved in tumor development and infertility features. Twenty-four patients were selected based on their region of residence and clinical information availability. Several genes were differentially expressed between women living in metropolitan areas and Sao Paulo city. Significant associations were observed between <i>BCL-2</i>, <i>DVL1</i>, <i>FGFR3</i>, and <i>WNT5b</i> downregulation and contraceptive use in the samples from women living in Sao Paulo city. <i>ESR1</i> and <i>HHAT</i> downregulation was associated with ethnicity. <i>WNT5b</i> and <i>GREM</i> were associated with LM treatment and related pathologies, respectively. In the samples from women living in other cities of the metropolitan region, abortion occurrence was associated with <i>BMP4</i> upregulation. Although further studies may be necessary, our results showed that air pollution exposure influences the expression of genes related to LM development and female reproductive features.https://www.mdpi.com/1422-0067/24/3/2431uterine leiomyomaair pollutiongene expressionreal-time PCRtumorigenesisfertility |
| spellingShingle | Laura Gonzalez dos Anjos Bruna Cristine de Almeida Edmund Chada Baracat Ayman Al-Hendy Qiwei Yang Katia Candido Carvalho Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil International Journal of Molecular Sciences uterine leiomyoma air pollution gene expression real-time PCR tumorigenesis fertility |
| title | Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil |
| title_full | Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil |
| title_fullStr | Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil |
| title_full_unstemmed | Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil |
| title_short | Gene Expression Profile of Uterine Leiomyoma from Women Exposed to Different Air Pollution Levels in Metropolitan Cities of Sao Paulo, Brazil |
| title_sort | gene expression profile of uterine leiomyoma from women exposed to different air pollution levels in metropolitan cities of sao paulo brazil |
| topic | uterine leiomyoma air pollution gene expression real-time PCR tumorigenesis fertility |
| url | https://www.mdpi.com/1422-0067/24/3/2431 |
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