Comparison between diagnostic performance of intestinal Fusobacterium nucleatum, Bacteroides fragilis and Escherichia coli in 5-fluorouracil resistance to colorectal cancer: A meta‑analysis
Background: Intestinal Fusobacterium nucleatum (F. nucleatum) infection has been implicated into the progression of colorectal cancer (CRC). However, F. nucleatum as a biomarker in 5-fluorouracil (5-FU) resistance of CRC has not been fully analyzed by comparing with other types of gut microbiota. In...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Cancer Treatment and Research Communications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2468294222000272 |
| _version_ | 1811188902962135040 |
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| author | Wen-Yu Wang Hang Zhou Zhi Wang Yu-Hang Zhang |
| author_facet | Wen-Yu Wang Hang Zhou Zhi Wang Yu-Hang Zhang |
| author_sort | Wen-Yu Wang |
| collection | DOAJ |
| description | Background: Intestinal Fusobacterium nucleatum (F. nucleatum) infection has been implicated into the progression of colorectal cancer (CRC). However, F. nucleatum as a biomarker in 5-fluorouracil (5-FU) resistance of CRC has not been fully analyzed by comparing with other types of gut microbiota. In order to further reduce the random error and bias of individual research, this meta‑analysis aimed to compare the diagnostic performance of intestinal Fusobacterium nucleatum, Bacteroides fragilis and Escherichia coli in 5-FU resistance to colorectal cancer and provide evidence‑based data to clinical practice. Methods: Comprehensive searches of PubMed, Embase, Cochrane Library and Web of Science databases were conducted. A total of 11 studies were selected according to the preestablished inclusion and exclusion criteria and analyzed by Review Manager 5.4 software, which included mapping of forest plots, heterogeneity tests, meta‑regression, sensitivity analysis and publication bias. Results: Overall sensitivity and specificity of F. nucleatum detection in 5-FU resistance of CRC were 0.65 (95% CI:0.60–0.69) and 0.70 (95% CI:0.59–0.87), respectively. Its positive likelihood ratio (PLR) and negative likelihood ratio (NLR) in detecting colorectal cancer were 2.57 (95% CI:1.47–3.21) and 0.52 (95% CI:0.43–0.63). The diagnostic odds ratio (DOR) was 4.92 (95% CI:2.23–7.33), which significantly exceeds the performance of B. fragilis (DOR: 0.53, 95% CI:0.31–0.82) and E. coli (DOR: 0.63, 95% CI: 0.57–0.76) for indicating 5-FU resistance of CRC. Conclusion: Compared with intestinal B. fragilis and intestinal E. coli, intestinal F. nucleatum is more reflective of 5-FU resistance to colorectal cancer. |
| first_indexed | 2024-04-11T14:27:03Z |
| format | Article |
| id | doaj.art-e40541bb8cda45c797c439e12d4254d5 |
| institution | Directory Open Access Journal |
| issn | 2468-2942 |
| language | English |
| last_indexed | 2024-04-11T14:27:03Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cancer Treatment and Research Communications |
| spelling | doaj.art-e40541bb8cda45c797c439e12d4254d52022-12-22T04:18:51ZengElsevierCancer Treatment and Research Communications2468-29422022-01-0132100536Comparison between diagnostic performance of intestinal Fusobacterium nucleatum, Bacteroides fragilis and Escherichia coli in 5-fluorouracil resistance to colorectal cancer: A meta‑analysisWen-Yu Wang0Hang Zhou1Zhi Wang2Yu-Hang Zhang3Beijing Friendship Hospital, Capital Medical University Beijing,100050 ChinaBeijing Friendship Hospital, Capital Medical University Beijing,100050 ChinaDepartment of Cardiology, Xuanwu Hospital, Capital Medical University, Beijing,100053 China; Corresponding author.Institute of Clinical Pharmacology, Peking University First Hospital, Beijing,100034 China; Institute of Clinical Pharmacology, Peking University First Hospital, Beijing,100191 China; Corresponding author.Background: Intestinal Fusobacterium nucleatum (F. nucleatum) infection has been implicated into the progression of colorectal cancer (CRC). However, F. nucleatum as a biomarker in 5-fluorouracil (5-FU) resistance of CRC has not been fully analyzed by comparing with other types of gut microbiota. In order to further reduce the random error and bias of individual research, this meta‑analysis aimed to compare the diagnostic performance of intestinal Fusobacterium nucleatum, Bacteroides fragilis and Escherichia coli in 5-FU resistance to colorectal cancer and provide evidence‑based data to clinical practice. Methods: Comprehensive searches of PubMed, Embase, Cochrane Library and Web of Science databases were conducted. A total of 11 studies were selected according to the preestablished inclusion and exclusion criteria and analyzed by Review Manager 5.4 software, which included mapping of forest plots, heterogeneity tests, meta‑regression, sensitivity analysis and publication bias. Results: Overall sensitivity and specificity of F. nucleatum detection in 5-FU resistance of CRC were 0.65 (95% CI:0.60–0.69) and 0.70 (95% CI:0.59–0.87), respectively. Its positive likelihood ratio (PLR) and negative likelihood ratio (NLR) in detecting colorectal cancer were 2.57 (95% CI:1.47–3.21) and 0.52 (95% CI:0.43–0.63). The diagnostic odds ratio (DOR) was 4.92 (95% CI:2.23–7.33), which significantly exceeds the performance of B. fragilis (DOR: 0.53, 95% CI:0.31–0.82) and E. coli (DOR: 0.63, 95% CI: 0.57–0.76) for indicating 5-FU resistance of CRC. Conclusion: Compared with intestinal B. fragilis and intestinal E. coli, intestinal F. nucleatum is more reflective of 5-FU resistance to colorectal cancer.http://www.sciencedirect.com/science/article/pii/S24682942220002725-Fluorouracil (5-FU) resistanceColorectal cancer (CRC)Fusobacterium nucleatum (F. nucleatum, Fn)Bacteroides fragilis (B. fragilis)Escherichia coli (E. coli) |
| spellingShingle | Wen-Yu Wang Hang Zhou Zhi Wang Yu-Hang Zhang Comparison between diagnostic performance of intestinal Fusobacterium nucleatum, Bacteroides fragilis and Escherichia coli in 5-fluorouracil resistance to colorectal cancer: A meta‑analysis Cancer Treatment and Research Communications 5-Fluorouracil (5-FU) resistance Colorectal cancer (CRC) Fusobacterium nucleatum (F. nucleatum, Fn) Bacteroides fragilis (B. fragilis) Escherichia coli (E. coli) |
| title | Comparison between diagnostic performance of intestinal Fusobacterium nucleatum, Bacteroides fragilis and Escherichia coli in 5-fluorouracil resistance to colorectal cancer: A meta‑analysis |
| title_full | Comparison between diagnostic performance of intestinal Fusobacterium nucleatum, Bacteroides fragilis and Escherichia coli in 5-fluorouracil resistance to colorectal cancer: A meta‑analysis |
| title_fullStr | Comparison between diagnostic performance of intestinal Fusobacterium nucleatum, Bacteroides fragilis and Escherichia coli in 5-fluorouracil resistance to colorectal cancer: A meta‑analysis |
| title_full_unstemmed | Comparison between diagnostic performance of intestinal Fusobacterium nucleatum, Bacteroides fragilis and Escherichia coli in 5-fluorouracil resistance to colorectal cancer: A meta‑analysis |
| title_short | Comparison between diagnostic performance of intestinal Fusobacterium nucleatum, Bacteroides fragilis and Escherichia coli in 5-fluorouracil resistance to colorectal cancer: A meta‑analysis |
| title_sort | comparison between diagnostic performance of intestinal fusobacterium nucleatum bacteroides fragilis and escherichia coli in 5 fluorouracil resistance to colorectal cancer a meta analysis |
| topic | 5-Fluorouracil (5-FU) resistance Colorectal cancer (CRC) Fusobacterium nucleatum (F. nucleatum, Fn) Bacteroides fragilis (B. fragilis) Escherichia coli (E. coli) |
| url | http://www.sciencedirect.com/science/article/pii/S2468294222000272 |
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