Unsymmetrically substituted imidazolium salts: synthesis, characterization and antimicrobial activity
ABSTRACT Unsymmetrically substituted imidazolium salts were synthesized and characterized using 1H-NMR and 13C-NMR. The antimicrobial activities of the salts were evaluated using the agar-well diffusion method against 14 bacteria and five yeasts. The minimal inhibitory concentrations (MIC) against s...
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2017-04-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100604&lng=en&tlng=en |
| _version_ | 1818389940236451840 |
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| author | Esin Poyrazoğlu Çoban Rukiye Fırıncı Halil Biyik Muhammet Emin Günay |
| author_facet | Esin Poyrazoğlu Çoban Rukiye Fırıncı Halil Biyik Muhammet Emin Günay |
| author_sort | Esin Poyrazoğlu Çoban |
| collection | DOAJ |
| description | ABSTRACT Unsymmetrically substituted imidazolium salts were synthesized and characterized using 1H-NMR and 13C-NMR. The antimicrobial activities of the salts were evaluated using the agar-well diffusion method against 14 bacteria and five yeasts. The minimal inhibitory concentrations (MIC) against seven bacteria and one yeast were also determined. Among the test compounds applied, 1, 2, 3, 6 and 11 showed activities against Micrococcus luteus ATCC 9341, Staphylococcus aureus ATCC 25923, Staphylococcus epidermidis ATCC 12228, Bacilllus cereus ATCC 11778, Bacillus subtilis ATCC 6633, Bacillus thuringiensis, Listeria monocytogenes ATCC 19112 and Candida trophicalis. However, compounds 1, 2 and 3 showed the highest antimicrobial activities against Micrococcus luteus ATCC 9341, Stapylococcus aureus ATCC 25923, Staphylococcus epidermidis ATCC 12228, Bacilllus cereus ATCC 11778 and Bacillus subtilis ATCC 6633 with inhibition zones of 14-20 mm. In addition, compound 6 have only demonstrated activities against Candida trophicalis while compounds 4, 5, 7, 8, 9, 10, 12, 13 and 14 had no effect on test microorganisms. |
| first_indexed | 2024-12-14T04:49:43Z |
| format | Article |
| id | doaj.art-e406e9b67ad6475d871fd0604038a2e9 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-14T04:49:43Z |
| publishDate | 2017-04-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-e406e9b67ad6475d871fd0604038a2e92022-12-21T23:16:35ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902017-04-0153110.1590/s2175-97902017000115075S1984-82502017000100604Unsymmetrically substituted imidazolium salts: synthesis, characterization and antimicrobial activityEsin Poyrazoğlu ÇobanRukiye FırıncıHalil BiyikMuhammet Emin GünayABSTRACT Unsymmetrically substituted imidazolium salts were synthesized and characterized using 1H-NMR and 13C-NMR. The antimicrobial activities of the salts were evaluated using the agar-well diffusion method against 14 bacteria and five yeasts. The minimal inhibitory concentrations (MIC) against seven bacteria and one yeast were also determined. Among the test compounds applied, 1, 2, 3, 6 and 11 showed activities against Micrococcus luteus ATCC 9341, Staphylococcus aureus ATCC 25923, Staphylococcus epidermidis ATCC 12228, Bacilllus cereus ATCC 11778, Bacillus subtilis ATCC 6633, Bacillus thuringiensis, Listeria monocytogenes ATCC 19112 and Candida trophicalis. However, compounds 1, 2 and 3 showed the highest antimicrobial activities against Micrococcus luteus ATCC 9341, Stapylococcus aureus ATCC 25923, Staphylococcus epidermidis ATCC 12228, Bacilllus cereus ATCC 11778 and Bacillus subtilis ATCC 6633 with inhibition zones of 14-20 mm. In addition, compound 6 have only demonstrated activities against Candida trophicalis while compounds 4, 5, 7, 8, 9, 10, 12, 13 and 14 had no effect on test microorganisms.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100604&lng=en&tlng=enImidazolium salts/characterizationN-heterocyclic carbenesImidazolium salts/antimicrobial activityImidazolium salts/Minimum inhibitory concentration. |
| spellingShingle | Esin Poyrazoğlu Çoban Rukiye Fırıncı Halil Biyik Muhammet Emin Günay Unsymmetrically substituted imidazolium salts: synthesis, characterization and antimicrobial activity Brazilian Journal of Pharmaceutical Sciences Imidazolium salts/characterization N-heterocyclic carbenes Imidazolium salts/antimicrobial activity Imidazolium salts/Minimum inhibitory concentration. |
| title | Unsymmetrically substituted imidazolium salts: synthesis, characterization and antimicrobial activity |
| title_full | Unsymmetrically substituted imidazolium salts: synthesis, characterization and antimicrobial activity |
| title_fullStr | Unsymmetrically substituted imidazolium salts: synthesis, characterization and antimicrobial activity |
| title_full_unstemmed | Unsymmetrically substituted imidazolium salts: synthesis, characterization and antimicrobial activity |
| title_short | Unsymmetrically substituted imidazolium salts: synthesis, characterization and antimicrobial activity |
| title_sort | unsymmetrically substituted imidazolium salts synthesis characterization and antimicrobial activity |
| topic | Imidazolium salts/characterization N-heterocyclic carbenes Imidazolium salts/antimicrobial activity Imidazolium salts/Minimum inhibitory concentration. |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100604&lng=en&tlng=en |
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