Gut Microbiota Prevents Sugar Alcohol-Induced Diarrhea
While poorly-absorbed sugar alcohols such as sorbitol are widely used as sweeteners, they may induce diarrhea in some individuals. However, the factors which determine an individual’s susceptibility to sugar alcohol-induced diarrhea remain unknown. Here, we show that specific gut bacteria are involv...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/6/2029 |
| _version_ | 1797530361592283136 |
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| author | Kouya Hattori Masahiro Akiyama Natsumi Seki Kyosuke Yakabe Koji Hase Yun-Gi Kim |
| author_facet | Kouya Hattori Masahiro Akiyama Natsumi Seki Kyosuke Yakabe Koji Hase Yun-Gi Kim |
| author_sort | Kouya Hattori |
| collection | DOAJ |
| description | While poorly-absorbed sugar alcohols such as sorbitol are widely used as sweeteners, they may induce diarrhea in some individuals. However, the factors which determine an individual’s susceptibility to sugar alcohol-induced diarrhea remain unknown. Here, we show that specific gut bacteria are involved in the suppression of sorbitol-induced diarrhea. Based on 16S rDNA analysis, the abundance of Enterobacteriaceae bacteria increased in response to sorbitol consumption. We found that <i>Escherichia coli</i> of the family Enterobacteriaceae degraded sorbitol and suppressed sorbitol-induced diarrhea. Finally, we showed that the metabolism of sorbitol by the <i>E. coli</i> sugar phosphotransferase system helped suppress sorbitol-induced diarrhea. Therefore, gut microbiota prevented sugar alcohol-induced diarrhea by degrading sorbitol in the gut. The identification of the gut bacteria which respond to and degrade sugar alcohols in the intestine has implications for microbiome science, processed food science, and public health. |
| first_indexed | 2024-03-10T10:27:49Z |
| format | Article |
| id | doaj.art-e409a4084a604a7cb90a8d3362568aca |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T10:27:49Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-e409a4084a604a7cb90a8d3362568aca2023-11-21T23:53:38ZengMDPI AGNutrients2072-66432021-06-01136202910.3390/nu13062029Gut Microbiota Prevents Sugar Alcohol-Induced DiarrheaKouya Hattori0Masahiro Akiyama1Natsumi Seki2Kyosuke Yakabe3Koji Hase4Yun-Gi Kim5Research Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, JapanResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, JapanResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, JapanResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, JapanDepartment of Biochemistry, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, JapanResearch Center for Drug Discovery, Faculty of Pharmacy and Graduate School of Pharmaceutical Sciences, Keio University, Tokyo 105-8512, JapanWhile poorly-absorbed sugar alcohols such as sorbitol are widely used as sweeteners, they may induce diarrhea in some individuals. However, the factors which determine an individual’s susceptibility to sugar alcohol-induced diarrhea remain unknown. Here, we show that specific gut bacteria are involved in the suppression of sorbitol-induced diarrhea. Based on 16S rDNA analysis, the abundance of Enterobacteriaceae bacteria increased in response to sorbitol consumption. We found that <i>Escherichia coli</i> of the family Enterobacteriaceae degraded sorbitol and suppressed sorbitol-induced diarrhea. Finally, we showed that the metabolism of sorbitol by the <i>E. coli</i> sugar phosphotransferase system helped suppress sorbitol-induced diarrhea. Therefore, gut microbiota prevented sugar alcohol-induced diarrhea by degrading sorbitol in the gut. The identification of the gut bacteria which respond to and degrade sugar alcohols in the intestine has implications for microbiome science, processed food science, and public health.https://www.mdpi.com/2072-6643/13/6/2029gut microbiotasugar alcoholdiarrhea |
| spellingShingle | Kouya Hattori Masahiro Akiyama Natsumi Seki Kyosuke Yakabe Koji Hase Yun-Gi Kim Gut Microbiota Prevents Sugar Alcohol-Induced Diarrhea Nutrients gut microbiota sugar alcohol diarrhea |
| title | Gut Microbiota Prevents Sugar Alcohol-Induced Diarrhea |
| title_full | Gut Microbiota Prevents Sugar Alcohol-Induced Diarrhea |
| title_fullStr | Gut Microbiota Prevents Sugar Alcohol-Induced Diarrhea |
| title_full_unstemmed | Gut Microbiota Prevents Sugar Alcohol-Induced Diarrhea |
| title_short | Gut Microbiota Prevents Sugar Alcohol-Induced Diarrhea |
| title_sort | gut microbiota prevents sugar alcohol induced diarrhea |
| topic | gut microbiota sugar alcohol diarrhea |
| url | https://www.mdpi.com/2072-6643/13/6/2029 |
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