Neomycin, but Not Neamine, Blocks Angiogenic Factor Induced Nitric Oxide Release through Inhibition of Akt Phosphorylation

Neomycin, but Not Neamine, Blocks Angiogenic Factor Induced Nitric Oxide Release through Inhibition of Akt Phosphorylation

Angiogenesis, the growth of new blood vessels, is a critical factor of carcinogenesis. Neomycin and neamine, two drugs blocking the nuclear translocation of angiogenin (ANG), have been proven to inhibit tumour growth in vivo. However, the high toxicity of neomycin prevents its therapeutic use, thus...

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Bibliographic Details
Main Authors: Raphaël Trouillon, Dong-Ku Kang, Soo-Ik Chang, Danny O’Hare
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
cells-on-a-chip
drug screening
angiogenesis
nitric oxide
bio-electrochemical methods
Online Access:https://www.mdpi.com/1422-0067/23/23/15277

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