Antibacterial and antioxidant activities of curcumin/Zn metal complex with its chemical characterization and spectroscopic studies
Curcumin is an active component of the rhizome turmeric. Curcumin/zinc (Cur/Zn) complex was synthesized and characterized using the elemental analysis, the molar conductance, FT-IR, UV–Vis,1HNMR, scanning (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD). The molar conductanc...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023046765 |
| _version_ | 1797794037705474048 |
|---|---|
| author | Eman Hillal Al-Thubaiti |
| author_facet | Eman Hillal Al-Thubaiti |
| author_sort | Eman Hillal Al-Thubaiti |
| collection | DOAJ |
| description | Curcumin is an active component of the rhizome turmeric. Curcumin/zinc (Cur/Zn) complex was synthesized and characterized using the elemental analysis, the molar conductance, FT-IR, UV–Vis,1HNMR, scanning (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD). The molar conductance value is very low, referring to the absence of Cl− ions inside or outside chelate sphere confirming non electrolytic nature. Based on IR and electronic spectra curcumin CO group in enol form chelated to Zn (II) ion. The surface morphology of curcumin chelate with Zn showed elevated in particle size and irregular grains shaped with elongated morphology. Transmission electron microscopy revealed that the curcumin chelate with Zn has spherical black spots like shape with particle size range from (33–97 nm). The antioxidant activities of curcumin and Cur/Zn complex were assessed. Results showed that the Cur/Zn complex showed potent antioxidant activities than curcumin. For antibacterial activity, Curcumin/Zn showed inhibitory effect against both (+ve and –ve) gram bacteria (Bacillus subtilis and Escherichia coli) at very low concentration. Cur/Zn recorded antibacterial and inhibition activity at 0.009 against E. coli and at 0.625 against B. subtilis. Cur/Zn complex showed higher capacity in scavenging the ABTS radical, FARAP capacity and metal chelating activity than curcumin itself and it showed more scavenging and inhibition activity for DPPH. The synthesized complex of Cur/Zn showed potent antioxidant and antibacterial activities than curcumin itself and it may benefit in treatment of aging and degenerative diseases with elevated and excessive production of free radicals. |
| first_indexed | 2024-03-13T02:57:01Z |
| format | Article |
| id | doaj.art-e40a7f7ee40140de97e908e840b6e554 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T02:57:01Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-e40a7f7ee40140de97e908e840b6e5542023-06-28T04:29:59ZengElsevierHeliyon2405-84402023-06-0196e17468Antibacterial and antioxidant activities of curcumin/Zn metal complex with its chemical characterization and spectroscopic studiesEman Hillal Al-Thubaiti0Biotechnology Department, College of Sciences, Taif University, Taif-P.O. Box 11099, Taif, 21944, Saudi ArabiaCurcumin is an active component of the rhizome turmeric. Curcumin/zinc (Cur/Zn) complex was synthesized and characterized using the elemental analysis, the molar conductance, FT-IR, UV–Vis,1HNMR, scanning (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD). The molar conductance value is very low, referring to the absence of Cl− ions inside or outside chelate sphere confirming non electrolytic nature. Based on IR and electronic spectra curcumin CO group in enol form chelated to Zn (II) ion. The surface morphology of curcumin chelate with Zn showed elevated in particle size and irregular grains shaped with elongated morphology. Transmission electron microscopy revealed that the curcumin chelate with Zn has spherical black spots like shape with particle size range from (33–97 nm). The antioxidant activities of curcumin and Cur/Zn complex were assessed. Results showed that the Cur/Zn complex showed potent antioxidant activities than curcumin. For antibacterial activity, Curcumin/Zn showed inhibitory effect against both (+ve and –ve) gram bacteria (Bacillus subtilis and Escherichia coli) at very low concentration. Cur/Zn recorded antibacterial and inhibition activity at 0.009 against E. coli and at 0.625 against B. subtilis. Cur/Zn complex showed higher capacity in scavenging the ABTS radical, FARAP capacity and metal chelating activity than curcumin itself and it showed more scavenging and inhibition activity for DPPH. The synthesized complex of Cur/Zn showed potent antioxidant and antibacterial activities than curcumin itself and it may benefit in treatment of aging and degenerative diseases with elevated and excessive production of free radicals.http://www.sciencedirect.com/science/article/pii/S2405844023046765AntioxidantCurcuminMetal complexAntibacterialSpectroscopicDPPH |
| spellingShingle | Eman Hillal Al-Thubaiti Antibacterial and antioxidant activities of curcumin/Zn metal complex with its chemical characterization and spectroscopic studies Heliyon Antioxidant Curcumin Metal complex Antibacterial Spectroscopic DPPH |
| title | Antibacterial and antioxidant activities of curcumin/Zn metal complex with its chemical characterization and spectroscopic studies |
| title_full | Antibacterial and antioxidant activities of curcumin/Zn metal complex with its chemical characterization and spectroscopic studies |
| title_fullStr | Antibacterial and antioxidant activities of curcumin/Zn metal complex with its chemical characterization and spectroscopic studies |
| title_full_unstemmed | Antibacterial and antioxidant activities of curcumin/Zn metal complex with its chemical characterization and spectroscopic studies |
| title_short | Antibacterial and antioxidant activities of curcumin/Zn metal complex with its chemical characterization and spectroscopic studies |
| title_sort | antibacterial and antioxidant activities of curcumin zn metal complex with its chemical characterization and spectroscopic studies |
| topic | Antioxidant Curcumin Metal complex Antibacterial Spectroscopic DPPH |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023046765 |
| work_keys_str_mv | AT emanhillalalthubaiti antibacterialandantioxidantactivitiesofcurcuminznmetalcomplexwithitschemicalcharacterizationandspectroscopicstudies |