Determination of the median effective dose of sufentanil for inhibiting the laryngeal mask insertion response in geriatric patients: a prospective, double-blinded, dose–response trial
Abstract Background Laryngeal mask airway(LMA) have been widely used in clinical practice. Irritation to the patient during the insertion of a laryngeal mask can cause hemodynamic fluctuations, which is particularly unsafe for geriatric patients. We used probit regression analysis to determine the m...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-07-01
|
| Series: | BMC Anesthesiology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12871-022-01758-7 |
| _version_ | 1811294592204537856 |
|---|---|
| author | ShiFang Wang WeiBing Wang JinBo Xiao HongPing Yu Hui Zhou Huang Xu |
| author_facet | ShiFang Wang WeiBing Wang JinBo Xiao HongPing Yu Hui Zhou Huang Xu |
| author_sort | ShiFang Wang |
| collection | DOAJ |
| description | Abstract Background Laryngeal mask airway(LMA) have been widely used in clinical practice. Irritation to the patient during the insertion of a laryngeal mask can cause hemodynamic fluctuations, which is particularly unsafe for geriatric patients. We used probit regression analysis to determine the median effective dose of sufentanil to inhibit the response to LMA insertion in geriatric patients. Methods A total of 90 patients were selected for the study using the following inclusion criteria: age ≥ 65 years old, ASA grade I–III, and scheduled to undergo intravenous general anesthesia with LMA insertion. Each patient received a dose of sufentanil for anesthesia induction in one of six levels: 0.05, 0.1, 0.15, 0.2, 0.25, or 0.3 μg kg−1. LMA insertion was scored with a 3-point, 6-category scale, with scores ≥ 16 indicating effective LMA insertion, and < 16 indicating ineffective LMA insertion. Mean arterial blood pressure (MAP), heart rate (HR), and bispectral index (BIS) were recorded 1 min before induction (T1), 1 min after induction (T2), 1 min after LMA insertion (T3), and 5 min after LMA insertion (T4) in each group. In addition, the plasma norepinephrine (NE) levels and adverse reactions were measured at T2 and T3 in each dosage group. Results Probit regression analysis showed that the ED50 of sufentanil inhibiting the response to LMA insertion in geriatric patients was 0.18 μg kg−1 (95% CI: 0.16–0.21 μg kg−1), and the ED95 was 0.31 μg kg−1 (95% CI: 0.27–0.38 μg kg−1), and the probit(p) = -2.34 + 12.90 × ln(Dose)( $$\chi^{2}$$ χ 2 = 0.725, p = 0.948). Among all the patients, the number of effective LMA insertions was 57 (group A), and the number of ineffective LMA insertions was 33 (group B). The MAP, HR, and NE in group B were significantly higher than in group A at T3. Conclusions Sufentanil can effectively inhibit the patient’s response to LMA insertion, with stable hemodynamics and small stress response. The ED50 and ED95 were 0.18 μg kg−1 (95% CI: 0.16–0.21 μg kg−1) and 0.31 μg kg−1(95% CI: 0.27–0.38 μg kg−1), respectively. Trial registration This study was registered in the Chinese Clinical Trial Registry (Registration number: ChiCTR2100051827 ) on October 6, 2021. |
| first_indexed | 2024-04-13T05:19:42Z |
| format | Article |
| id | doaj.art-e40d85003527489680ae562cfaa2daf9 |
| institution | Directory Open Access Journal |
| issn | 1471-2253 |
| language | English |
| last_indexed | 2024-04-13T05:19:42Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Anesthesiology |
| spelling | doaj.art-e40d85003527489680ae562cfaa2daf92022-12-22T03:00:47ZengBMCBMC Anesthesiology1471-22532022-07-012211810.1186/s12871-022-01758-7Determination of the median effective dose of sufentanil for inhibiting the laryngeal mask insertion response in geriatric patients: a prospective, double-blinded, dose–response trialShiFang Wang0WeiBing Wang1JinBo Xiao2HongPing Yu3Hui Zhou4Huang Xu5Department of Anesthesiology, The Affiliated AnQing Municipal Hospitals of Anhui Medical UniversityDepartment of Anesthesiology, The Affiliated AnQing Municipal Hospitals of Anhui Medical UniversityDepartment of Anesthesiology, The Affiliated AnQing Municipal Hospitals of Anhui Medical UniversityDepartment of Anesthesiology, The Affiliated AnQing Municipal Hospitals of Anhui Medical UniversityDepartment of Anesthesiology, The Affiliated AnQing Municipal Hospitals of Anhui Medical UniversityDepartment of Anesthesiology, The Affiliated AnQing Municipal Hospitals of Anhui Medical UniversityAbstract Background Laryngeal mask airway(LMA) have been widely used in clinical practice. Irritation to the patient during the insertion of a laryngeal mask can cause hemodynamic fluctuations, which is particularly unsafe for geriatric patients. We used probit regression analysis to determine the median effective dose of sufentanil to inhibit the response to LMA insertion in geriatric patients. Methods A total of 90 patients were selected for the study using the following inclusion criteria: age ≥ 65 years old, ASA grade I–III, and scheduled to undergo intravenous general anesthesia with LMA insertion. Each patient received a dose of sufentanil for anesthesia induction in one of six levels: 0.05, 0.1, 0.15, 0.2, 0.25, or 0.3 μg kg−1. LMA insertion was scored with a 3-point, 6-category scale, with scores ≥ 16 indicating effective LMA insertion, and < 16 indicating ineffective LMA insertion. Mean arterial blood pressure (MAP), heart rate (HR), and bispectral index (BIS) were recorded 1 min before induction (T1), 1 min after induction (T2), 1 min after LMA insertion (T3), and 5 min after LMA insertion (T4) in each group. In addition, the plasma norepinephrine (NE) levels and adverse reactions were measured at T2 and T3 in each dosage group. Results Probit regression analysis showed that the ED50 of sufentanil inhibiting the response to LMA insertion in geriatric patients was 0.18 μg kg−1 (95% CI: 0.16–0.21 μg kg−1), and the ED95 was 0.31 μg kg−1 (95% CI: 0.27–0.38 μg kg−1), and the probit(p) = -2.34 + 12.90 × ln(Dose)( $$\chi^{2}$$ χ 2 = 0.725, p = 0.948). Among all the patients, the number of effective LMA insertions was 57 (group A), and the number of ineffective LMA insertions was 33 (group B). The MAP, HR, and NE in group B were significantly higher than in group A at T3. Conclusions Sufentanil can effectively inhibit the patient’s response to LMA insertion, with stable hemodynamics and small stress response. The ED50 and ED95 were 0.18 μg kg−1 (95% CI: 0.16–0.21 μg kg−1) and 0.31 μg kg−1(95% CI: 0.27–0.38 μg kg−1), respectively. Trial registration This study was registered in the Chinese Clinical Trial Registry (Registration number: ChiCTR2100051827 ) on October 6, 2021.https://doi.org/10.1186/s12871-022-01758-7SufentanilEtomidateLaryngeal mask airwayGeriatricMedian effective dose |
| spellingShingle | ShiFang Wang WeiBing Wang JinBo Xiao HongPing Yu Hui Zhou Huang Xu Determination of the median effective dose of sufentanil for inhibiting the laryngeal mask insertion response in geriatric patients: a prospective, double-blinded, dose–response trial BMC Anesthesiology Sufentanil Etomidate Laryngeal mask airway Geriatric Median effective dose |
| title | Determination of the median effective dose of sufentanil for inhibiting the laryngeal mask insertion response in geriatric patients: a prospective, double-blinded, dose–response trial |
| title_full | Determination of the median effective dose of sufentanil for inhibiting the laryngeal mask insertion response in geriatric patients: a prospective, double-blinded, dose–response trial |
| title_fullStr | Determination of the median effective dose of sufentanil for inhibiting the laryngeal mask insertion response in geriatric patients: a prospective, double-blinded, dose–response trial |
| title_full_unstemmed | Determination of the median effective dose of sufentanil for inhibiting the laryngeal mask insertion response in geriatric patients: a prospective, double-blinded, dose–response trial |
| title_short | Determination of the median effective dose of sufentanil for inhibiting the laryngeal mask insertion response in geriatric patients: a prospective, double-blinded, dose–response trial |
| title_sort | determination of the median effective dose of sufentanil for inhibiting the laryngeal mask insertion response in geriatric patients a prospective double blinded dose response trial |
| topic | Sufentanil Etomidate Laryngeal mask airway Geriatric Median effective dose |
| url | https://doi.org/10.1186/s12871-022-01758-7 |
| work_keys_str_mv | AT shifangwang determinationofthemedianeffectivedoseofsufentanilforinhibitingthelaryngealmaskinsertionresponseingeriatricpatientsaprospectivedoubleblindeddoseresponsetrial AT weibingwang determinationofthemedianeffectivedoseofsufentanilforinhibitingthelaryngealmaskinsertionresponseingeriatricpatientsaprospectivedoubleblindeddoseresponsetrial AT jinboxiao determinationofthemedianeffectivedoseofsufentanilforinhibitingthelaryngealmaskinsertionresponseingeriatricpatientsaprospectivedoubleblindeddoseresponsetrial AT hongpingyu determinationofthemedianeffectivedoseofsufentanilforinhibitingthelaryngealmaskinsertionresponseingeriatricpatientsaprospectivedoubleblindeddoseresponsetrial AT huizhou determinationofthemedianeffectivedoseofsufentanilforinhibitingthelaryngealmaskinsertionresponseingeriatricpatientsaprospectivedoubleblindeddoseresponsetrial AT huangxu determinationofthemedianeffectivedoseofsufentanilforinhibitingthelaryngealmaskinsertionresponseingeriatricpatientsaprospectivedoubleblindeddoseresponsetrial |