A Novel Type-I Interferon Family, Bovine Interferon-Chi, Is Involved in Positive-Feedback Regulation of Interferon Production

A Novel Type-I Interferon Family, Bovine Interferon-Chi, Is Involved in Positive-Feedback Regulation of Interferon Production

Interferon-chi (IFN-χ) is a type of function-unknown IFN. IFN-χ in bovines (BoIFN-χ) has evolved as a multigene family. This family comprises four IFN-χ subtypes, two of which are functional genes, which we demonstrated to (i) have antiviral and antiproliferative activities, (ii) be highly sensitive...

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Bibliographic Details
Main Authors: Yongli Guo, Zhifeng Song, Chenfeng Li, Yueyang Yu, Haiyue Dai, Xiuxin Luo, Yujiao Wang, Junwei Wang, Mingchun Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
bovine IFN-χ
molecular characterization
antiviral activity
JAK-STAT signaling pathway
positive feedback regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.528854/full

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