Role of Blood Lactate Clearance in Predicting Outcomes among Septic Patients Admitted to the PICU: A Prospective Cohort Study
Introduction: A crucial metric for evaluating the effectiveness of microcirculation in septic shock is serum lactate. Lactate clearance within the first 24 hours of admission has predictive value for death in Paediatric Intensive Care Unit (PICU) admissions. Higher mortality was observed in septic p...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2024-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/19164/66601_CE[Ra1]_F(IS)_QC(AN_RDW_IS)_PF1(RI_OM)_PFA(RI_KM)_PN(KM).pdf |
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| author | Akanksha Rana Mangla Sood Arvind Sood |
| author_facet | Akanksha Rana Mangla Sood Arvind Sood |
| author_sort | Akanksha Rana |
| collection | DOAJ |
| description | Introduction: A crucial metric for evaluating the effectiveness of microcirculation in septic shock is serum lactate. Lactate clearance within the first 24 hours of admission has predictive value for death in Paediatric Intensive Care Unit (PICU) admissions. Higher mortality was observed in septic patients who were unable to clear elevated admission lactate.
Aim: To determine the admission lactate level and to investigate whether failure to clear elevated lactate in septic patients can prognosticate high PICU mortality.
Materials and Methods: This prospective cohort study was conducted from August 2021 to July 2022 at PICU, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India. A total of 75 children, aged two months to 18 years, admitted to the PICU for sepsis or septic shock, were enrolled in the study. The authors measured blood lactate at Intensive Care Unit (ICU) admission, at 6, 12, and 24 hours. Lactate clearance was calculated, and its association with mortality after 24 hours of PICU stay was measured using the Chi-square test.
Results: Out of the total, 55 survived, comprising 31 males (41.3%) and 44 females (58.7%). When comparing admission blood lactate to lactate clearance >10% at 6, 12, and 24 hours, there was no correlation between the two variables and mortality in PICU patients with sepsis.
Conclusion: Lactate clearance in the first 24 hours of PICU stay was recommended as a parameter associated with the mortality rate among septic patients. However, the authors did not find any correlation. |
| first_indexed | 2024-04-25T01:14:09Z |
| format | Article |
| id | doaj.art-e411ff299cd74e509a9fe6b28afa3e1d |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-25T01:14:09Z |
| publishDate | 2024-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-e411ff299cd74e509a9fe6b28afa3e1d2024-03-09T11:56:51ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2024-03-011803060810.7860/JCDR/2024/66601.19164Role of Blood Lactate Clearance in Predicting Outcomes among Septic Patients Admitted to the PICU: A Prospective Cohort StudyAkanksha Rana0Mangla Sood1Arvind Sood2Junior Resident, Department of Paediatrics, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.Professor, Department of Paediatrics, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.Professor, Department of Paediatrics, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.Introduction: A crucial metric for evaluating the effectiveness of microcirculation in septic shock is serum lactate. Lactate clearance within the first 24 hours of admission has predictive value for death in Paediatric Intensive Care Unit (PICU) admissions. Higher mortality was observed in septic patients who were unable to clear elevated admission lactate. Aim: To determine the admission lactate level and to investigate whether failure to clear elevated lactate in septic patients can prognosticate high PICU mortality. Materials and Methods: This prospective cohort study was conducted from August 2021 to July 2022 at PICU, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India. A total of 75 children, aged two months to 18 years, admitted to the PICU for sepsis or septic shock, were enrolled in the study. The authors measured blood lactate at Intensive Care Unit (ICU) admission, at 6, 12, and 24 hours. Lactate clearance was calculated, and its association with mortality after 24 hours of PICU stay was measured using the Chi-square test. Results: Out of the total, 55 survived, comprising 31 males (41.3%) and 44 females (58.7%). When comparing admission blood lactate to lactate clearance >10% at 6, 12, and 24 hours, there was no correlation between the two variables and mortality in PICU patients with sepsis. Conclusion: Lactate clearance in the first 24 hours of PICU stay was recommended as a parameter associated with the mortality rate among septic patients. However, the authors did not find any correlation.https://www.jcdr.net/articles/PDF/19164/66601_CE[Ra1]_F(IS)_QC(AN_RDW_IS)_PF1(RI_OM)_PFA(RI_KM)_PN(KM).pdfchildlactic acidpaediatric intensive care unitprognosisseptic shocksepsis |
| spellingShingle | Akanksha Rana Mangla Sood Arvind Sood Role of Blood Lactate Clearance in Predicting Outcomes among Septic Patients Admitted to the PICU: A Prospective Cohort Study Journal of Clinical and Diagnostic Research child lactic acid paediatric intensive care unit prognosis septic shock sepsis |
| title | Role of Blood Lactate Clearance in Predicting Outcomes among Septic Patients Admitted to the PICU: A Prospective Cohort Study |
| title_full | Role of Blood Lactate Clearance in Predicting Outcomes among Septic Patients Admitted to the PICU: A Prospective Cohort Study |
| title_fullStr | Role of Blood Lactate Clearance in Predicting Outcomes among Septic Patients Admitted to the PICU: A Prospective Cohort Study |
| title_full_unstemmed | Role of Blood Lactate Clearance in Predicting Outcomes among Septic Patients Admitted to the PICU: A Prospective Cohort Study |
| title_short | Role of Blood Lactate Clearance in Predicting Outcomes among Septic Patients Admitted to the PICU: A Prospective Cohort Study |
| title_sort | role of blood lactate clearance in predicting outcomes among septic patients admitted to the picu a prospective cohort study |
| topic | child lactic acid paediatric intensive care unit prognosis septic shock sepsis |
| url | https://www.jcdr.net/articles/PDF/19164/66601_CE[Ra1]_F(IS)_QC(AN_RDW_IS)_PF1(RI_OM)_PFA(RI_KM)_PN(KM).pdf |
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