Effects of pretreatment with different neuromuscular blocking agents on facilitation of intubation with rocuronium: A prospective randomized comparative study
Background and Aims: Priming principle refers to administration of a small dose of non-depolarising blocker, which when followed by a large intubating dose produces a relatively rapid and profound blockade to ensure suitable conditions for endotracheal intubation. We aimed to compare the effects of...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014-01-01
|
| Series: | Indian Journal of Anaesthesia |
| Subjects: | |
| Online Access: | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2014;volume=58;issue=3;spage=303;epage=308;aulast=Shashank |
| _version_ | 1819225055395053568 |
|---|---|
| author | D S Shashank N Ratan Singh L Kameshwar Singh |
| author_facet | D S Shashank N Ratan Singh L Kameshwar Singh |
| author_sort | D S Shashank |
| collection | DOAJ |
| description | Background and Aims: Priming principle refers to administration of a small dose of non-depolarising blocker, which when followed by a large intubating dose produces a relatively rapid and profound blockade to ensure suitable conditions for endotracheal intubation. We aimed to compare the effects of rocuronium, vecuronium, and atracurium as "pretreatment" drugs on intubating conditions with rocuronium facilitated endotracheal intubation. Methods: This double-blinded, randomised controlled prospective study was carried out at a tertiary health care hospital on patients undergoing surgical procedures under general anaesthesia. They were randomly allocated into three groups (n = 35) by computer generated randomisation chart to receive either rocuronium (0.06 mg/kg body weight) (Group A); vecuronium (0.01 mg/kg body weight) (Group B) or, atracurium (0.05 mg/kg body weight) (Group C), followed by intubating dose (0.6 mg/kg body weight) of rocuronium. The haemodynamic parameters and intubating conditions were studied and statistically analysed by ANOVA test and Student′s t-test as applicable using statistical package for the social sciences 16.0 for windows (SPSS Inc., Chicago, IL, USA). Results: Excellent intubating conditions were noted in maximum number of patients in Group C (97.41%). No significant differences were observed in the systolic blood pressure in all the three groups at all-time intervals. The mean arterial pressure rose significantly from baseline value to maximum, at ′0′ min in all the groups; however, no significant difference was observed amongst the groups (P > 0.05). Conclusion: Pretreatment with rocuronium bromide can facilitate endotracheal intubation in 60 s irrespective of non-depolarising muscle relaxants used for priming; however, it cannot attenuate haemodynamic changes associated with laryngoscopy and intubation. |
| first_indexed | 2024-12-23T10:03:31Z |
| format | Article |
| id | doaj.art-e41355f2475a4fa89c20ff518d22fbbb |
| institution | Directory Open Access Journal |
| issn | 0019-5049 |
| language | English |
| last_indexed | 2024-12-23T10:03:31Z |
| publishDate | 2014-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Anaesthesia |
| spelling | doaj.art-e41355f2475a4fa89c20ff518d22fbbb2022-12-21T17:51:10ZengWolters Kluwer Medknow PublicationsIndian Journal of Anaesthesia0019-50492014-01-0158330330810.4103/0019-5049.135043Effects of pretreatment with different neuromuscular blocking agents on facilitation of intubation with rocuronium: A prospective randomized comparative studyD S ShashankN Ratan SinghL Kameshwar SinghBackground and Aims: Priming principle refers to administration of a small dose of non-depolarising blocker, which when followed by a large intubating dose produces a relatively rapid and profound blockade to ensure suitable conditions for endotracheal intubation. We aimed to compare the effects of rocuronium, vecuronium, and atracurium as "pretreatment" drugs on intubating conditions with rocuronium facilitated endotracheal intubation. Methods: This double-blinded, randomised controlled prospective study was carried out at a tertiary health care hospital on patients undergoing surgical procedures under general anaesthesia. They were randomly allocated into three groups (n = 35) by computer generated randomisation chart to receive either rocuronium (0.06 mg/kg body weight) (Group A); vecuronium (0.01 mg/kg body weight) (Group B) or, atracurium (0.05 mg/kg body weight) (Group C), followed by intubating dose (0.6 mg/kg body weight) of rocuronium. The haemodynamic parameters and intubating conditions were studied and statistically analysed by ANOVA test and Student′s t-test as applicable using statistical package for the social sciences 16.0 for windows (SPSS Inc., Chicago, IL, USA). Results: Excellent intubating conditions were noted in maximum number of patients in Group C (97.41%). No significant differences were observed in the systolic blood pressure in all the three groups at all-time intervals. The mean arterial pressure rose significantly from baseline value to maximum, at ′0′ min in all the groups; however, no significant difference was observed amongst the groups (P > 0.05). Conclusion: Pretreatment with rocuronium bromide can facilitate endotracheal intubation in 60 s irrespective of non-depolarising muscle relaxants used for priming; however, it cannot attenuate haemodynamic changes associated with laryngoscopy and intubation.http://www.ijaweb.org/article.asp?issn=0019-5049;year=2014;volume=58;issue=3;spage=303;epage=308;aulast=ShashankAtracuriumintubating conditionpretreatmentrocuroniumvecuronium |
| spellingShingle | D S Shashank N Ratan Singh L Kameshwar Singh Effects of pretreatment with different neuromuscular blocking agents on facilitation of intubation with rocuronium: A prospective randomized comparative study Indian Journal of Anaesthesia Atracurium intubating condition pretreatment rocuronium vecuronium |
| title | Effects of pretreatment with different neuromuscular blocking agents on facilitation of intubation with rocuronium: A prospective randomized comparative study |
| title_full | Effects of pretreatment with different neuromuscular blocking agents on facilitation of intubation with rocuronium: A prospective randomized comparative study |
| title_fullStr | Effects of pretreatment with different neuromuscular blocking agents on facilitation of intubation with rocuronium: A prospective randomized comparative study |
| title_full_unstemmed | Effects of pretreatment with different neuromuscular blocking agents on facilitation of intubation with rocuronium: A prospective randomized comparative study |
| title_short | Effects of pretreatment with different neuromuscular blocking agents on facilitation of intubation with rocuronium: A prospective randomized comparative study |
| title_sort | effects of pretreatment with different neuromuscular blocking agents on facilitation of intubation with rocuronium a prospective randomized comparative study |
| topic | Atracurium intubating condition pretreatment rocuronium vecuronium |
| url | http://www.ijaweb.org/article.asp?issn=0019-5049;year=2014;volume=58;issue=3;spage=303;epage=308;aulast=Shashank |
| work_keys_str_mv | AT dsshashank effectsofpretreatmentwithdifferentneuromuscularblockingagentsonfacilitationofintubationwithrocuroniumaprospectiverandomizedcomparativestudy AT nratansingh effectsofpretreatmentwithdifferentneuromuscularblockingagentsonfacilitationofintubationwithrocuroniumaprospectiverandomizedcomparativestudy AT lkameshwarsingh effectsofpretreatmentwithdifferentneuromuscularblockingagentsonfacilitationofintubationwithrocuroniumaprospectiverandomizedcomparativestudy |