Serum Vitamin D as a Biomarker in Autoimmune, Psychiatric and Neurodegenerative Diseases
Vitamin D is a steroid hormone regulating calcium-phosphorus homeostasis, immune response and brain function. In the past thirty years, an increasing number of cohort studies, meta-analyses and randomized controlled trials (RTCs) evaluated the serum levels of 25-hydroxyvitamin D [25(OH)D], which is...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/1/130 |
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| author | Giulia Bivona Caterina Maria Gambino Bruna Lo Sasso Concetta Scazzone Rosaria Vincenza Giglio Luisa Agnello Marcello Ciaccio |
| author_facet | Giulia Bivona Caterina Maria Gambino Bruna Lo Sasso Concetta Scazzone Rosaria Vincenza Giglio Luisa Agnello Marcello Ciaccio |
| author_sort | Giulia Bivona |
| collection | DOAJ |
| description | Vitamin D is a steroid hormone regulating calcium-phosphorus homeostasis, immune response and brain function. In the past thirty years, an increasing number of cohort studies, meta-analyses and randomized controlled trials (RTCs) evaluated the serum levels of 25-hydroxyvitamin D [25(OH)D], which is considered the Vitamin D status biomarker, in patients affected by neurological, psychiatric and autoimmune diseases. Although an association between low 25(OH)D serum levels and the prevalence of these diseases has been found, it is still unclear whether the serum 25(OH)D measurement can be clinically useful as a biomarker for diagnosis, prognosis and predicting treatment response in neurodegeneration, mental illness and immune-mediated disorders. The lack of standardized data, as well as discrepancies among the studies (in the analytical methods, cut-offs, endpoints and study sets), weakened the findings achieved, hindered pooling data, and, consequently, hampered drawing conclusions. This narrative review summarizes the main findings from the studies performed on serum 25(OH)D in neurological, psychiatric and autoimmune diseases, and clarifies whether or not serum 25(OH)D can be used as a reliable biomarker in these diseases. |
| first_indexed | 2024-03-10T01:38:54Z |
| format | Article |
| id | doaj.art-e414a39e5a65490594496d75ddcd2163 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T01:38:54Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-e414a39e5a65490594496d75ddcd21632023-11-23T13:28:46ZengMDPI AGDiagnostics2075-44182022-01-0112113010.3390/diagnostics12010130Serum Vitamin D as a Biomarker in Autoimmune, Psychiatric and Neurodegenerative DiseasesGiulia Bivona0Caterina Maria Gambino1Bruna Lo Sasso2Concetta Scazzone3Rosaria Vincenza Giglio4Luisa Agnello5Marcello Ciaccio6Department of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, University of Palermo, 90127 Palermo, ItalyDepartment of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, University of Palermo, 90127 Palermo, ItalyDepartment of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, University of Palermo, 90127 Palermo, ItalyDepartment of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, University of Palermo, 90127 Palermo, ItalyDepartment of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, University of Palermo, 90127 Palermo, ItalyDepartment of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, University of Palermo, 90127 Palermo, ItalyDepartment of Biomedicine, Neurosciences and Advanced Diagnostics, Institute of Clinical Biochemistry, Clinical Molecular Medicine and Clinical Laboratory Medicine, University of Palermo, 90127 Palermo, ItalyVitamin D is a steroid hormone regulating calcium-phosphorus homeostasis, immune response and brain function. In the past thirty years, an increasing number of cohort studies, meta-analyses and randomized controlled trials (RTCs) evaluated the serum levels of 25-hydroxyvitamin D [25(OH)D], which is considered the Vitamin D status biomarker, in patients affected by neurological, psychiatric and autoimmune diseases. Although an association between low 25(OH)D serum levels and the prevalence of these diseases has been found, it is still unclear whether the serum 25(OH)D measurement can be clinically useful as a biomarker for diagnosis, prognosis and predicting treatment response in neurodegeneration, mental illness and immune-mediated disorders. The lack of standardized data, as well as discrepancies among the studies (in the analytical methods, cut-offs, endpoints and study sets), weakened the findings achieved, hindered pooling data, and, consequently, hampered drawing conclusions. This narrative review summarizes the main findings from the studies performed on serum 25(OH)D in neurological, psychiatric and autoimmune diseases, and clarifies whether or not serum 25(OH)D can be used as a reliable biomarker in these diseases.https://www.mdpi.com/2075-4418/12/1/130vitamin Dbiomarkerautoimmune diseasesneurodegenerative diseasespsychiatric diseasesAlzheimer’s disease |
| spellingShingle | Giulia Bivona Caterina Maria Gambino Bruna Lo Sasso Concetta Scazzone Rosaria Vincenza Giglio Luisa Agnello Marcello Ciaccio Serum Vitamin D as a Biomarker in Autoimmune, Psychiatric and Neurodegenerative Diseases Diagnostics vitamin D biomarker autoimmune diseases neurodegenerative diseases psychiatric diseases Alzheimer’s disease |
| title | Serum Vitamin D as a Biomarker in Autoimmune, Psychiatric and Neurodegenerative Diseases |
| title_full | Serum Vitamin D as a Biomarker in Autoimmune, Psychiatric and Neurodegenerative Diseases |
| title_fullStr | Serum Vitamin D as a Biomarker in Autoimmune, Psychiatric and Neurodegenerative Diseases |
| title_full_unstemmed | Serum Vitamin D as a Biomarker in Autoimmune, Psychiatric and Neurodegenerative Diseases |
| title_short | Serum Vitamin D as a Biomarker in Autoimmune, Psychiatric and Neurodegenerative Diseases |
| title_sort | serum vitamin d as a biomarker in autoimmune psychiatric and neurodegenerative diseases |
| topic | vitamin D biomarker autoimmune diseases neurodegenerative diseases psychiatric diseases Alzheimer’s disease |
| url | https://www.mdpi.com/2075-4418/12/1/130 |
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