Platelet-to-lymphocyte ratio at 24h after thrombolysis is a prognostic marker in acute ischemic stroke patients
BackgroundThe changes in the platelet-to-lymphocyte ratio (PLR) before and after recombinant tissue plasminogen activator (rtPA) treatment and the time point at which the PLR is a potentially valuable prognostic predictor in patients wit ischemic stroke remain largely unknown. Therefore, the purpose...
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| Format: | Article |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1000626/full |
| _version_ | 1818017351193329664 |
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| author | Ying-Ying Sun Mei-Qi Wang Yan Wang Xin Sun Yang Qu Hong-Jing Zhu Si-Ji Wang Xiu-Li Yan Hang Jin Peng Zhang Yi Yang Yi Yang Zhen-Ni Guo Zhen-Ni Guo Zhen-Ni Guo |
| author_facet | Ying-Ying Sun Mei-Qi Wang Yan Wang Xin Sun Yang Qu Hong-Jing Zhu Si-Ji Wang Xiu-Li Yan Hang Jin Peng Zhang Yi Yang Yi Yang Zhen-Ni Guo Zhen-Ni Guo Zhen-Ni Guo |
| author_sort | Ying-Ying Sun |
| collection | DOAJ |
| description | BackgroundThe changes in the platelet-to-lymphocyte ratio (PLR) before and after recombinant tissue plasminogen activator (rtPA) treatment and the time point at which the PLR is a potentially valuable prognostic predictor in patients wit ischemic stroke remain largely unknown. Therefore, the purpose of this study was to explore the characteristics of the PLR and evaluate their effects on clinical outcomes before and 24 h after rtPA treatment.MethodsThis study included 741 consecutive patients with acute ischemic stroke who underwent intravenous thrombolysis with rtPA. We collected data on demographics, vascular risk factors, medication history, and other clinical information pertaining to all patients. Specifically, blood samples for PLR measurement were collected on admission and 24 h after stroke. The outcome was assessed by using the Modified Rankin Scale (mRS) at 3 months and whether death occurred within 3 months or not. Univariate and multivariate logistic regression analysis was used to assess the association of the PLR with the risks of poor outcome (mRS>2) and death. An individualized prediction model was established to predict poor outcome.ResultsOf the 741 patients, 255 (34.4%) had poor outcome, and 43 (5.8%) died. The PLR significantly increased 24 h after rtPA in patients with poor outcome and death. Logistic analysis revealed that higher PLR 24 h after rtPA was independently associated with increased risks of poor outcome and death. However, the PLR on admission was not associated with the risks of poor outcome and death. The individualized prediction model for poor outcome based on the 24-h PLR exhibited favorable discrimination (areas under the curves of the training and validation groups: 0.743 and 0.729, respectively), calibration (P > 0.05), and clinical usefulness.ConclusionsWe found the PLR to be a variable that potentially predicts the risks of poor outcome and death in patients with acute ischemic stroke 24 h after rtPA; however, it cannot make the same prediction on admission. |
| first_indexed | 2024-04-14T07:25:57Z |
| format | Article |
| id | doaj.art-e41579ab2e0443da82b4aa8628368dba |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-14T07:25:57Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e41579ab2e0443da82b4aa8628368dba2022-12-22T02:06:01ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-09-011310.3389/fimmu.2022.10006261000626Platelet-to-lymphocyte ratio at 24h after thrombolysis is a prognostic marker in acute ischemic stroke patientsYing-Ying Sun0Mei-Qi Wang1Yan Wang2Xin Sun3Yang Qu4Hong-Jing Zhu5Si-Ji Wang6Xiu-Li Yan7Hang Jin8Peng Zhang9Yi Yang10Yi Yang11Zhen-Ni Guo12Zhen-Ni Guo13Zhen-Ni Guo14Stroke Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, Jilin, ChinaStroke Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, Jilin, ChinaStroke Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, Jilin, ChinaStroke Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, Jilin, ChinaStroke Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, Jilin, ChinaStroke Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, Jilin, ChinaStroke Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, Jilin, ChinaStroke Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, Jilin, ChinaStroke Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, Jilin, ChinaStroke Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, Jilin, ChinaStroke Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, Jilin, ChinaJilin Provincial Key Laboratory of Cerebrovascular Disease, Chang Chun, ChinaStroke Center, Department of Neurology, the First Hospital of Jilin University, Chang Chun, Jilin, ChinaJilin Provincial Key Laboratory of Cerebrovascular Disease, Chang Chun, ChinaNeuroscience Research Center, the First Hospital of Jilin University, Chang Chun, Jilin, ChinaBackgroundThe changes in the platelet-to-lymphocyte ratio (PLR) before and after recombinant tissue plasminogen activator (rtPA) treatment and the time point at which the PLR is a potentially valuable prognostic predictor in patients wit ischemic stroke remain largely unknown. Therefore, the purpose of this study was to explore the characteristics of the PLR and evaluate their effects on clinical outcomes before and 24 h after rtPA treatment.MethodsThis study included 741 consecutive patients with acute ischemic stroke who underwent intravenous thrombolysis with rtPA. We collected data on demographics, vascular risk factors, medication history, and other clinical information pertaining to all patients. Specifically, blood samples for PLR measurement were collected on admission and 24 h after stroke. The outcome was assessed by using the Modified Rankin Scale (mRS) at 3 months and whether death occurred within 3 months or not. Univariate and multivariate logistic regression analysis was used to assess the association of the PLR with the risks of poor outcome (mRS>2) and death. An individualized prediction model was established to predict poor outcome.ResultsOf the 741 patients, 255 (34.4%) had poor outcome, and 43 (5.8%) died. The PLR significantly increased 24 h after rtPA in patients with poor outcome and death. Logistic analysis revealed that higher PLR 24 h after rtPA was independently associated with increased risks of poor outcome and death. However, the PLR on admission was not associated with the risks of poor outcome and death. The individualized prediction model for poor outcome based on the 24-h PLR exhibited favorable discrimination (areas under the curves of the training and validation groups: 0.743 and 0.729, respectively), calibration (P > 0.05), and clinical usefulness.ConclusionsWe found the PLR to be a variable that potentially predicts the risks of poor outcome and death in patients with acute ischemic stroke 24 h after rtPA; however, it cannot make the same prediction on admission.https://www.frontiersin.org/articles/10.3389/fimmu.2022.1000626/fullplatelet-to-lymphocyte ratioacute ischemic strokeintravenous thrombolysisoutcomedeath |
| spellingShingle | Ying-Ying Sun Mei-Qi Wang Yan Wang Xin Sun Yang Qu Hong-Jing Zhu Si-Ji Wang Xiu-Li Yan Hang Jin Peng Zhang Yi Yang Yi Yang Zhen-Ni Guo Zhen-Ni Guo Zhen-Ni Guo Platelet-to-lymphocyte ratio at 24h after thrombolysis is a prognostic marker in acute ischemic stroke patients Frontiers in Immunology platelet-to-lymphocyte ratio acute ischemic stroke intravenous thrombolysis outcome death |
| title | Platelet-to-lymphocyte ratio at 24h after thrombolysis is a prognostic marker in acute ischemic stroke patients |
| title_full | Platelet-to-lymphocyte ratio at 24h after thrombolysis is a prognostic marker in acute ischemic stroke patients |
| title_fullStr | Platelet-to-lymphocyte ratio at 24h after thrombolysis is a prognostic marker in acute ischemic stroke patients |
| title_full_unstemmed | Platelet-to-lymphocyte ratio at 24h after thrombolysis is a prognostic marker in acute ischemic stroke patients |
| title_short | Platelet-to-lymphocyte ratio at 24h after thrombolysis is a prognostic marker in acute ischemic stroke patients |
| title_sort | platelet to lymphocyte ratio at 24h after thrombolysis is a prognostic marker in acute ischemic stroke patients |
| topic | platelet-to-lymphocyte ratio acute ischemic stroke intravenous thrombolysis outcome death |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1000626/full |
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