Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional study
IntroductionTorque teno virus (TTV) has been pointed as an endogenous marker of immune function, the objective of this study was to investigate the TTV viral load in plasma and saliva of cirrhotic individuals and correlate it with clinical characteristics.MethodsBlood, saliva, clinical data from rec...
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Frontiers Media S.A.
2023-06-01
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Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1184353/full |
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author | Ana Clara Falabello de Luca Gabriella Bueno Marinho Juliana Bertoldi Franco Jefferson da Rocha Tenório Jefferson da Rocha Tenório Natália Silva Andrade Natália Silva Andrade Alexandre Mendes Batista Ana Carolina Mamana Tânia Regina Tozetto-Mendoza Mário Pérez Sayáns Paulo Henrique Braz-Silva Paulo Henrique Braz-Silva Karem L. Ortega |
author_facet | Ana Clara Falabello de Luca Gabriella Bueno Marinho Juliana Bertoldi Franco Jefferson da Rocha Tenório Jefferson da Rocha Tenório Natália Silva Andrade Natália Silva Andrade Alexandre Mendes Batista Ana Carolina Mamana Tânia Regina Tozetto-Mendoza Mário Pérez Sayáns Paulo Henrique Braz-Silva Paulo Henrique Braz-Silva Karem L. Ortega |
author_sort | Ana Clara Falabello de Luca |
collection | DOAJ |
description | IntroductionTorque teno virus (TTV) has been pointed as an endogenous marker of immune function, the objective of this study was to investigate the TTV viral load in plasma and saliva of cirrhotic individuals and correlate it with clinical characteristics.MethodsBlood, saliva, clinical data from records and laboratory tests were collected from 72 cirrhotic patients. Plasma and saliva were submitted to real-time polymerase chain reaction for quantification of TTV viral load.ResultsThe majority of the patients presented decompensated cirrhosis (59.7%) and 47.2% had alterations in the white blood series. TTV was identified in 28 specimens of plasma (38.8%) and in 67 specimens of saliva (93.0%), with median values of TTV copies/mL of 90.6 in plasma and 245.14 in saliva. All the patients who were positive for TTV in plasma were also positive in saliva, with both fluids having a moderately positive correlation for the presence of TTV. There was no correlation between TTV viral load, either in plasma or in saliva, and any of the variables studied.ConclusionTTV is more frequently found and in greater amount in the saliva than in the plasma of cirrhotic patients. There was no correlation between TTV viral load and clinical parameters. |
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language | English |
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spelling | doaj.art-e41a197ba4014a19a9ff360d5cf7b1052023-06-22T09:39:56ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-06-011010.3389/fmed.2023.11843531184353Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional studyAna Clara Falabello de Luca0Gabriella Bueno Marinho1Juliana Bertoldi Franco2Jefferson da Rocha Tenório3Jefferson da Rocha Tenório4Natália Silva Andrade5Natália Silva Andrade6Alexandre Mendes Batista7Ana Carolina Mamana8Tânia Regina Tozetto-Mendoza9Mário Pérez Sayáns10Paulo Henrique Braz-Silva11Paulo Henrique Braz-Silva12Karem L. Ortega13Special Care Dentistry Centre (CAPE), Department of Stomatology, University of São Paulo, São Paulo, BrazilSpecial Care Dentistry Centre (CAPE), Department of Stomatology, University of São Paulo, São Paulo, BrazilDivision of Dentistry, Clinics Hospital, University of São Paulo, School of Medicine, São Paulo, BrazilSpecial Care Dentistry Centre (CAPE), Department of Stomatology, University of São Paulo, São Paulo, BrazilDepartment of Pathology and Oral Diagnosis, Federal University of Rio de Janeiro, Rio de Janeiro, BrazilSpecial Care Dentistry Centre (CAPE), Department of Stomatology, University of São Paulo, São Paulo, BrazilDepartment of Dentistry, Federal University of Sergipe, Lagarto, Sergipe, BrazilLaboratory of Virology, Institute of Tropical Medicine, School of Medicine, University of São Paulo, São Paulo, BrazilLaboratory of Virology, Institute of Tropical Medicine, School of Medicine, University of São Paulo, São Paulo, BrazilLaboratory of Virology, Institute of Tropical Medicine, School of Medicine, University of São Paulo, São Paulo, BrazilOral Medicine, Oral Surgery and Implantology Unit, MedOralRes Group, University of Santiago de Compostela, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, SpainLaboratory of Virology, Institute of Tropical Medicine, School of Medicine, University of São Paulo, São Paulo, BrazilDepartment of Stomatology, School of Dentistry, University of São Paulo, São Paulo, BrazilSpecial Care Dentistry Centre (CAPE), Department of Stomatology, University of São Paulo, São Paulo, BrazilIntroductionTorque teno virus (TTV) has been pointed as an endogenous marker of immune function, the objective of this study was to investigate the TTV viral load in plasma and saliva of cirrhotic individuals and correlate it with clinical characteristics.MethodsBlood, saliva, clinical data from records and laboratory tests were collected from 72 cirrhotic patients. Plasma and saliva were submitted to real-time polymerase chain reaction for quantification of TTV viral load.ResultsThe majority of the patients presented decompensated cirrhosis (59.7%) and 47.2% had alterations in the white blood series. TTV was identified in 28 specimens of plasma (38.8%) and in 67 specimens of saliva (93.0%), with median values of TTV copies/mL of 90.6 in plasma and 245.14 in saliva. All the patients who were positive for TTV in plasma were also positive in saliva, with both fluids having a moderately positive correlation for the presence of TTV. There was no correlation between TTV viral load, either in plasma or in saliva, and any of the variables studied.ConclusionTTV is more frequently found and in greater amount in the saliva than in the plasma of cirrhotic patients. There was no correlation between TTV viral load and clinical parameters.https://www.frontiersin.org/articles/10.3389/fmed.2023.1184353/fullliver cirrhosiscirrhosis-associated immune dysfunctiondecompensate cirrhosisTorque Teno virussalivaplasma |
spellingShingle | Ana Clara Falabello de Luca Gabriella Bueno Marinho Juliana Bertoldi Franco Jefferson da Rocha Tenório Jefferson da Rocha Tenório Natália Silva Andrade Natália Silva Andrade Alexandre Mendes Batista Ana Carolina Mamana Tânia Regina Tozetto-Mendoza Mário Pérez Sayáns Paulo Henrique Braz-Silva Paulo Henrique Braz-Silva Karem L. Ortega Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional study Frontiers in Medicine liver cirrhosis cirrhosis-associated immune dysfunction decompensate cirrhosis Torque Teno virus saliva plasma |
title | Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional study |
title_full | Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional study |
title_fullStr | Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional study |
title_full_unstemmed | Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional study |
title_short | Quantification of Torque Teno Virus (TTV) in plasma and saliva of individuals with liver cirrhosis: a cross sectional study |
title_sort | quantification of torque teno virus ttv in plasma and saliva of individuals with liver cirrhosis a cross sectional study |
topic | liver cirrhosis cirrhosis-associated immune dysfunction decompensate cirrhosis Torque Teno virus saliva plasma |
url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1184353/full |
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