Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation
Abstract Calcium phosphate cements (CPCs) are synthetic bioactive cements widely used as hard tissue substitutes. Critical limitations of use include their poor mechanical properties and poor anti-washout behaviour. To address those limitations, we combined CPC with genetically engineered elastin-li...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-018-23577-y |
| _version_ | 1818835161318424576 |
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| author | Ji-Hyun Jang Sumi Shin Hyun-Jung Kim Jinyoung Jeong Hyo-Eon Jin Malav S. Desai Seung-Wuk Lee Sun-Young Kim |
| author_facet | Ji-Hyun Jang Sumi Shin Hyun-Jung Kim Jinyoung Jeong Hyo-Eon Jin Malav S. Desai Seung-Wuk Lee Sun-Young Kim |
| author_sort | Ji-Hyun Jang |
| collection | DOAJ |
| description | Abstract Calcium phosphate cements (CPCs) are synthetic bioactive cements widely used as hard tissue substitutes. Critical limitations of use include their poor mechanical properties and poor anti-washout behaviour. To address those limitations, we combined CPC with genetically engineered elastin-like polypeptides (ELPs). We investigated the effect of the ELPs on the physical properties and biocompatibility of CPC by testing ELP/CPC composites with various liquid/powder ratios. Our results show that the addition of ELPs improved the mechanical properties of the CPC, including the microhardness, compressive strength, and washout resistance. The biocompatibility of ELP/CPC composites was also comparable to that of the CPC alone. However, supplementing CPC with ELPs functionalized with octaglutamate as a hydroxyapatite binding peptide increased the setting time of the cement. With further design and modification of our biomolecules and composites, our research will lead to products with diverse applications in biology and medicine. |
| first_indexed | 2024-12-19T02:46:19Z |
| format | Article |
| id | doaj.art-e41a54769c9145038929648220cb09d8 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T02:46:19Z |
| publishDate | 2018-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e41a54769c9145038929648220cb09d82022-12-21T20:38:53ZengNature PortfolioScientific Reports2045-23222018-03-018111110.1038/s41598-018-23577-yImprovement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementationJi-Hyun Jang0Sumi Shin1Hyun-Jung Kim2Jinyoung Jeong3Hyo-Eon Jin4Malav S. Desai5Seung-Wuk Lee6Sun-Young Kim7Department of Conservative Dentistry, School of Dentistry, Kyung Hee UniversityDepartment of Conservative Dentistry, Graduate School, Kyung Hee UniversityDepartment of Conservative Dentistry, Graduate School, Kyung Hee UniversityHazards Monitoring BNT Research Center, Korea Research Institute of Bioscience and Biotechnology, KRIBB School, University of Science and TechnologyCollege of Pharmacy, Ajou UniversityDepartment of Bioengineering, University of CaliforniaDepartment of Bioengineering, University of CaliforniaDepartment of Conservative Dentistry and Dental Research Institute, School of Dentistry, Seoul National UniversityAbstract Calcium phosphate cements (CPCs) are synthetic bioactive cements widely used as hard tissue substitutes. Critical limitations of use include their poor mechanical properties and poor anti-washout behaviour. To address those limitations, we combined CPC with genetically engineered elastin-like polypeptides (ELPs). We investigated the effect of the ELPs on the physical properties and biocompatibility of CPC by testing ELP/CPC composites with various liquid/powder ratios. Our results show that the addition of ELPs improved the mechanical properties of the CPC, including the microhardness, compressive strength, and washout resistance. The biocompatibility of ELP/CPC composites was also comparable to that of the CPC alone. However, supplementing CPC with ELPs functionalized with octaglutamate as a hydroxyapatite binding peptide increased the setting time of the cement. With further design and modification of our biomolecules and composites, our research will lead to products with diverse applications in biology and medicine.https://doi.org/10.1038/s41598-018-23577-y |
| spellingShingle | Ji-Hyun Jang Sumi Shin Hyun-Jung Kim Jinyoung Jeong Hyo-Eon Jin Malav S. Desai Seung-Wuk Lee Sun-Young Kim Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation Scientific Reports |
| title | Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation |
| title_full | Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation |
| title_fullStr | Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation |
| title_full_unstemmed | Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation |
| title_short | Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation |
| title_sort | improvement of physical properties of calcium phosphate cement by elastin like polypeptide supplementation |
| url | https://doi.org/10.1038/s41598-018-23577-y |
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