Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice

Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice

The adenosine triphosphate–binding cassette transporter A7 (ABCA7) gene is ranked as one of the top susceptibility loci for Alzheimer's disease (AD). While ABCA7 mediates lipid transport across cellular membranes, ABCA7 loss of function has been shown to exacerbate amyloid-β (Aβ) pathology and...

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Bibliographic Details
Main Authors: Xiaoye Ma, Dmitry Prokopenko, Ni Wang, Tomonori Aikawa, Younjung Choi, Can Zhang, Dan Lei, Yingxue Ren, Keiji Kawatani, Skylar C. Starling, Ralph B. Perkerson, Bhaskar Roy, Astrid C. Quintero, Tammee M. Parsons, Yining Pan, Zonghua Li, Minghui Wang, Hanmei Bao, Xianlin Han, Guojun Bu, Rudolph E. Tanzi, Takahisa Kanekiyo
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurobiology of Disease
Subjects:
ABCA7
Alzheimer's disease
Amyloid-β
Lipids
Microglia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125000294

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http://www.sciencedirect.com/science/article/pii/S0969996125000294

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