Dietary Iron Restriction Improves Muscle Function, Dyslipidemia, and Decreased Muscle Oxidative Stress in Streptozotocin-Induced Diabetic Rats
Diabetes mellitus is a chronic degenerative disease characterized by hyperglycemia and oxidative stress. Iron catalyzes free radical overproduction. High iron concentrations have previously been reported to promote an increase in oxidative stress; however, the effect of iron restriction in diabetes...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/4/731 |
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| author | Manuel Alejandro Vargas-Vargas Alfredo Saavedra-Molina Mariana Gómez-Barroso Donovan Peña-Montes Christian Cortés-Rojo Huerta Miguel Xochitl Trujillo Rocío Montoya-Pérez |
| author_facet | Manuel Alejandro Vargas-Vargas Alfredo Saavedra-Molina Mariana Gómez-Barroso Donovan Peña-Montes Christian Cortés-Rojo Huerta Miguel Xochitl Trujillo Rocío Montoya-Pérez |
| author_sort | Manuel Alejandro Vargas-Vargas |
| collection | DOAJ |
| description | Diabetes mellitus is a chronic degenerative disease characterized by hyperglycemia and oxidative stress. Iron catalyzes free radical overproduction. High iron concentrations have previously been reported to promote an increase in oxidative stress; however, the effect of iron restriction in diabetes has not yet been explored, so we tested to see if iron restriction in diabetic rats reduces oxidative damage and improved muscle function. Wistar rats were assigned to 4 groups: Control; Diabetic; Diabetic rats with a high iron diet, and Diabetic with dietary iron restriction. After 8 weeks the rats were sacrificed, the muscles were extracted to prepare homogenates, and serum was obtained for biochemical measurements. Low iron diabetic rats showed an increase in the development of muscle strength in both muscles. Dietary iron restriction decreased triglyceride concentrations compared to the untreated diabetic rats and the levels of extremely low-density lipoproteins. Aggravation of lipid peroxidation was observed in the diabetic group with a high iron diet, while these levels remained low with iron restriction. Iron restriction improved muscle strength development and reduced fatigue times; this was related to better lipid profile control and decreased oxidant stress markers. |
| first_indexed | 2024-03-09T11:14:26Z |
| format | Article |
| id | doaj.art-e41d87d0740542c7b04958d4f0d05506 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T11:14:26Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-e41d87d0740542c7b04958d4f0d055062023-12-01T00:35:56ZengMDPI AGAntioxidants2076-39212022-04-0111473110.3390/antiox11040731Dietary Iron Restriction Improves Muscle Function, Dyslipidemia, and Decreased Muscle Oxidative Stress in Streptozotocin-Induced Diabetic RatsManuel Alejandro Vargas-Vargas0Alfredo Saavedra-Molina1Mariana Gómez-Barroso2Donovan Peña-Montes3Christian Cortés-Rojo4Huerta Miguel5Xochitl Trujillo6Rocío Montoya-Pérez7Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Francisco J. Múgica S/N, Col. Felicitas del Río, Morelia 58030, MexicoInstituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Francisco J. Múgica S/N, Col. Felicitas del Río, Morelia 58030, MexicoInstituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Francisco J. Múgica S/N, Col. Felicitas del Río, Morelia 58030, MexicoInstituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Francisco J. Múgica S/N, Col. Felicitas del Río, Morelia 58030, MexicoInstituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Francisco J. Múgica S/N, Col. Felicitas del Río, Morelia 58030, MexicoCentro Universitario de Investigaciones Biomédicas, Universidad de Colima, Av. 25 de Julio 965, Las Víboras, Colima 24040, MexicoCentro Universitario de Investigaciones Biomédicas, Universidad de Colima, Av. 25 de Julio 965, Las Víboras, Colima 24040, MexicoInstituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Francisco J. Múgica S/N, Col. Felicitas del Río, Morelia 58030, MexicoDiabetes mellitus is a chronic degenerative disease characterized by hyperglycemia and oxidative stress. Iron catalyzes free radical overproduction. High iron concentrations have previously been reported to promote an increase in oxidative stress; however, the effect of iron restriction in diabetes has not yet been explored, so we tested to see if iron restriction in diabetic rats reduces oxidative damage and improved muscle function. Wistar rats were assigned to 4 groups: Control; Diabetic; Diabetic rats with a high iron diet, and Diabetic with dietary iron restriction. After 8 weeks the rats were sacrificed, the muscles were extracted to prepare homogenates, and serum was obtained for biochemical measurements. Low iron diabetic rats showed an increase in the development of muscle strength in both muscles. Dietary iron restriction decreased triglyceride concentrations compared to the untreated diabetic rats and the levels of extremely low-density lipoproteins. Aggravation of lipid peroxidation was observed in the diabetic group with a high iron diet, while these levels remained low with iron restriction. Iron restriction improved muscle strength development and reduced fatigue times; this was related to better lipid profile control and decreased oxidant stress markers.https://www.mdpi.com/2076-3921/11/4/731diabetesfatigueironoxidative stress |
| spellingShingle | Manuel Alejandro Vargas-Vargas Alfredo Saavedra-Molina Mariana Gómez-Barroso Donovan Peña-Montes Christian Cortés-Rojo Huerta Miguel Xochitl Trujillo Rocío Montoya-Pérez Dietary Iron Restriction Improves Muscle Function, Dyslipidemia, and Decreased Muscle Oxidative Stress in Streptozotocin-Induced Diabetic Rats Antioxidants diabetes fatigue iron oxidative stress |
| title | Dietary Iron Restriction Improves Muscle Function, Dyslipidemia, and Decreased Muscle Oxidative Stress in Streptozotocin-Induced Diabetic Rats |
| title_full | Dietary Iron Restriction Improves Muscle Function, Dyslipidemia, and Decreased Muscle Oxidative Stress in Streptozotocin-Induced Diabetic Rats |
| title_fullStr | Dietary Iron Restriction Improves Muscle Function, Dyslipidemia, and Decreased Muscle Oxidative Stress in Streptozotocin-Induced Diabetic Rats |
| title_full_unstemmed | Dietary Iron Restriction Improves Muscle Function, Dyslipidemia, and Decreased Muscle Oxidative Stress in Streptozotocin-Induced Diabetic Rats |
| title_short | Dietary Iron Restriction Improves Muscle Function, Dyslipidemia, and Decreased Muscle Oxidative Stress in Streptozotocin-Induced Diabetic Rats |
| title_sort | dietary iron restriction improves muscle function dyslipidemia and decreased muscle oxidative stress in streptozotocin induced diabetic rats |
| topic | diabetes fatigue iron oxidative stress |
| url | https://www.mdpi.com/2076-3921/11/4/731 |
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