Association between PrP genotypes and performance traits in a Welsh Mountain flock
The UK national scrapie plan (NSP) for sheep is based on selection for the resistant ARR/ARR genotype and elimination of susceptible types of the ovine prion protein (PrP) gene. The aim of this study was to estimate the possible association of the PrP genotype and performance traits by using data fr...
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| Format: | Article |
| Language: | English |
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Elsevier
2008-01-01
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| Series: | Animal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1751731108002747 |
| _version_ | 1818643401344548864 |
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| author | T.C. Pritchard C.M. Cahalan I. Ap Dewi |
| author_facet | T.C. Pritchard C.M. Cahalan I. Ap Dewi |
| author_sort | T.C. Pritchard |
| collection | DOAJ |
| description | The UK national scrapie plan (NSP) for sheep is based on selection for the resistant ARR/ARR genotype and elimination of susceptible types of the ovine prion protein (PrP) gene. The aim of this study was to estimate the possible association of the PrP genotype and performance traits by using data from the CAMDA Welsh Mountain flock. Four alleles (ARH, ARQ, ARR and VRQ) and 10 genotypes covering all five NSP risk groups were present in the CAMDA flock. Overall, the most common allele was ARR (35.2%), and VRQ was the least common (5.4%). The commonest genotypes were ARR/ARQ (23.7%) and ARR/AHQ (23.1%). The most resistant genotype, ARR/ARR, and the most susceptible genotype, VRQ/VRQ, were found in 10.2% and 0.3%, respectively, of the population tested. The associations of PrP genotypes with weight and ultrasonically scanned traits were investigated in three analyses, the first using genotypes, the second using risk categories and the third using number of alleles. These associations were evaluated by univariate analysis of each trait using an animal model with maternal effects where appropriate, and PrP was included as a fixed effect. Selection for scrapie resistance will not adversely affect progress in the traits considered and is consistent with improvements in muscle depth. |
| first_indexed | 2024-12-16T23:58:22Z |
| format | Article |
| id | doaj.art-e41fd936fc254592a60255354cff821e |
| institution | Directory Open Access Journal |
| issn | 1751-7311 |
| language | English |
| last_indexed | 2024-12-16T23:58:22Z |
| publishDate | 2008-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Animal |
| spelling | doaj.art-e41fd936fc254592a60255354cff821e2022-12-21T22:11:08ZengElsevierAnimal1751-73112008-01-0121014211426Association between PrP genotypes and performance traits in a Welsh Mountain flockT.C. Pritchard0C.M. Cahalan1I. Ap Dewi2School of the Environment and Natural Resources, Bangor University, Bangor, LL57 2UW, UKSchool of the Environment and Natural Resources, Bangor University, Bangor, LL57 2UW, UKSchool of the Environment and Natural Resources, Bangor University, Bangor, LL57 2UW, UKThe UK national scrapie plan (NSP) for sheep is based on selection for the resistant ARR/ARR genotype and elimination of susceptible types of the ovine prion protein (PrP) gene. The aim of this study was to estimate the possible association of the PrP genotype and performance traits by using data from the CAMDA Welsh Mountain flock. Four alleles (ARH, ARQ, ARR and VRQ) and 10 genotypes covering all five NSP risk groups were present in the CAMDA flock. Overall, the most common allele was ARR (35.2%), and VRQ was the least common (5.4%). The commonest genotypes were ARR/ARQ (23.7%) and ARR/AHQ (23.1%). The most resistant genotype, ARR/ARR, and the most susceptible genotype, VRQ/VRQ, were found in 10.2% and 0.3%, respectively, of the population tested. The associations of PrP genotypes with weight and ultrasonically scanned traits were investigated in three analyses, the first using genotypes, the second using risk categories and the third using number of alleles. These associations were evaluated by univariate analysis of each trait using an animal model with maternal effects where appropriate, and PrP was included as a fixed effect. Selection for scrapie resistance will not adversely affect progress in the traits considered and is consistent with improvements in muscle depth.http://www.sciencedirect.com/science/article/pii/S1751731108002747performance traitsPrP genotypescrapieWelsh Mountain sheep |
| spellingShingle | T.C. Pritchard C.M. Cahalan I. Ap Dewi Association between PrP genotypes and performance traits in a Welsh Mountain flock Animal performance traits PrP genotype scrapie Welsh Mountain sheep |
| title | Association between PrP genotypes and performance traits in a Welsh Mountain flock |
| title_full | Association between PrP genotypes and performance traits in a Welsh Mountain flock |
| title_fullStr | Association between PrP genotypes and performance traits in a Welsh Mountain flock |
| title_full_unstemmed | Association between PrP genotypes and performance traits in a Welsh Mountain flock |
| title_short | Association between PrP genotypes and performance traits in a Welsh Mountain flock |
| title_sort | association between prp genotypes and performance traits in a welsh mountain flock |
| topic | performance traits PrP genotype scrapie Welsh Mountain sheep |
| url | http://www.sciencedirect.com/science/article/pii/S1751731108002747 |
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