Prognostic value of the 2018 FIGO staging system for cervical cancer patients with surgical risk factors
Ding-Ding Yan, Qiu Tang, Jian-Hong Chen, Ye-Qiang Tu, Xiao-Juan LvDepartment of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou, People’s Republic of ChinaObjective: To determine the predictive value of the 2018 International Federation of Gynecology and Obstetrics (FIGO) staging...
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Dove Medical Press
2019-06-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/prognostic-value-of-the-2018-figo-staging-system-for-cervical-cancer-p-peer-reviewed-article-CMAR |
| _version_ | 1828863893668102144 |
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| author | Yan DD Tang Q Chen JH Tu YQ Lv XJ |
| author_facet | Yan DD Tang Q Chen JH Tu YQ Lv XJ |
| author_sort | Yan DD |
| collection | DOAJ |
| description | Ding-Ding Yan, Qiu Tang, Jian-Hong Chen, Ye-Qiang Tu, Xiao-Juan LvDepartment of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou, People’s Republic of ChinaObjective: To determine the predictive value of the 2018 International Federation of Gynecology and Obstetrics (FIGO) staging system for cervical cancer patients with surgical risk factors.Methods: Data of 662 cervical cancer patients (stages IB and IIA) with surgical risk factors treated at Zhejiang Cancer Hospital between 2008 and 2011 were retrospectively reviewed. Univariate log-rank test and multivariate Cox regression models were adopted to evaluate the relationship between 2018 FIGO stage and survival.Results: On re-staging of patients, 17.3%, 44.5%, 25.4%, and 37.1% of the patients with FIGO 2009 stage IB1, IB2, IIA1, and IIA2, respectively, were upgraded to FIGO 2018 IIIC1P stage, and 2.1%, 3.0%, 3.1%, and 2.1% patients, respectively, were upgraded to IIIC2P stage. The 5-year overall survival (OS) rates of patients with FIGO 2018 stage IB1, IB2, IB3, IIA1, IIA2, IIIC1P, and IIIC2P were 95.3%, 95.1%, 90.4%, 92.4%, 86.4%, 81.9%, and 56.3%, respectively. The 5-year progression-free survival (PFS) rates were 94.0%, 91.0%, 88.5%, 91.4%, 86.4%, 79.5%, and 43.8%, respectively. The 5-year OS rates of patients with 1–2 positive pelvic lymph nodes (PLNs) and those with >2 positive PLNs were 86.0% and 73.7%, respectively, and the 5-year PFS rates were 84.2% and 70.2%, respectively. OS and PFS of patients with 1–2 positive PLNs in stage IIIC1P were similar to those of patients in stage IIA2 without lymph node metastasis, but significantly better than those of patients with >2 positive PLNs. Multivariate analysis showed FIGO 2018 stage to be an independent prognostic factor for OS and PFS.Conclusion: The 2018 FIGO staging system for cervical cancer appears to be useful for predicting prognosis of patients with risk factors after radical surgery. Survival of stage IIA1 patients is better than that of stage IB3 patients. Stage IIIC1 is not homogenous; survival in stage IIIC1P depends on the number of positive PLNs.Keywords: cervical cancer, 5-year overall survival, 5-year progression-free survival, FIGO staging system
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| first_indexed | 2024-12-13T03:53:52Z |
| format | Article |
| id | doaj.art-e4203f9870164d38848a49145527dc4c |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-13T03:53:52Z |
| publishDate | 2019-06-01 |
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| series | Cancer Management and Research |
| spelling | doaj.art-e4203f9870164d38848a49145527dc4c2022-12-22T00:00:39ZengDove Medical PressCancer Management and Research1179-13222019-06-01Volume 115473548046436Prognostic value of the 2018 FIGO staging system for cervical cancer patients with surgical risk factorsYan DDTang QChen JHTu YQLv XJDing-Ding Yan, Qiu Tang, Jian-Hong Chen, Ye-Qiang Tu, Xiao-Juan LvDepartment of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou, People’s Republic of ChinaObjective: To determine the predictive value of the 2018 International Federation of Gynecology and Obstetrics (FIGO) staging system for cervical cancer patients with surgical risk factors.Methods: Data of 662 cervical cancer patients (stages IB and IIA) with surgical risk factors treated at Zhejiang Cancer Hospital between 2008 and 2011 were retrospectively reviewed. Univariate log-rank test and multivariate Cox regression models were adopted to evaluate the relationship between 2018 FIGO stage and survival.Results: On re-staging of patients, 17.3%, 44.5%, 25.4%, and 37.1% of the patients with FIGO 2009 stage IB1, IB2, IIA1, and IIA2, respectively, were upgraded to FIGO 2018 IIIC1P stage, and 2.1%, 3.0%, 3.1%, and 2.1% patients, respectively, were upgraded to IIIC2P stage. The 5-year overall survival (OS) rates of patients with FIGO 2018 stage IB1, IB2, IB3, IIA1, IIA2, IIIC1P, and IIIC2P were 95.3%, 95.1%, 90.4%, 92.4%, 86.4%, 81.9%, and 56.3%, respectively. The 5-year progression-free survival (PFS) rates were 94.0%, 91.0%, 88.5%, 91.4%, 86.4%, 79.5%, and 43.8%, respectively. The 5-year OS rates of patients with 1–2 positive pelvic lymph nodes (PLNs) and those with >2 positive PLNs were 86.0% and 73.7%, respectively, and the 5-year PFS rates were 84.2% and 70.2%, respectively. OS and PFS of patients with 1–2 positive PLNs in stage IIIC1P were similar to those of patients in stage IIA2 without lymph node metastasis, but significantly better than those of patients with >2 positive PLNs. Multivariate analysis showed FIGO 2018 stage to be an independent prognostic factor for OS and PFS.Conclusion: The 2018 FIGO staging system for cervical cancer appears to be useful for predicting prognosis of patients with risk factors after radical surgery. Survival of stage IIA1 patients is better than that of stage IB3 patients. Stage IIIC1 is not homogenous; survival in stage IIIC1P depends on the number of positive PLNs.Keywords: cervical cancer, 5-year overall survival, 5-year progression-free survival, FIGO staging system https://www.dovepress.com/prognostic-value-of-the-2018-figo-staging-system-for-cervical-cancer-p-peer-reviewed-article-CMARCervical cancer5-year overall survival5-year progression-free survivalFIGO staging system |
| spellingShingle | Yan DD Tang Q Chen JH Tu YQ Lv XJ Prognostic value of the 2018 FIGO staging system for cervical cancer patients with surgical risk factors Cancer Management and Research Cervical cancer 5-year overall survival 5-year progression-free survival FIGO staging system |
| title | Prognostic value of the 2018 FIGO staging system for cervical cancer patients with surgical risk factors |
| title_full | Prognostic value of the 2018 FIGO staging system for cervical cancer patients with surgical risk factors |
| title_fullStr | Prognostic value of the 2018 FIGO staging system for cervical cancer patients with surgical risk factors |
| title_full_unstemmed | Prognostic value of the 2018 FIGO staging system for cervical cancer patients with surgical risk factors |
| title_short | Prognostic value of the 2018 FIGO staging system for cervical cancer patients with surgical risk factors |
| title_sort | prognostic value of the 2018 figo staging system for cervical cancer patients with surgical risk factors |
| topic | Cervical cancer 5-year overall survival 5-year progression-free survival FIGO staging system |
| url | https://www.dovepress.com/prognostic-value-of-the-2018-figo-staging-system-for-cervical-cancer-p-peer-reviewed-article-CMAR |
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