NEUROPEPTIDES (SP AND CGRP) AUGMENT IL-1 BETA PRODUCTION IN HSV-INFECTED MACROPHAGES
Neuropeptides, possessing specific and functional receptors on various cells of the immune system, have the potential to regulate immune responses; and the macrophages as important components of defense against various agents, are at their influence. In this study the effect of neuropeptides substan...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2003-06-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/40 |
| _version_ | 1819171405954023424 |
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| author | Roya Yaraee Massoumeh Ebtekar A. Ahmadiani Farzanch Sabahi |
| author_facet | Roya Yaraee Massoumeh Ebtekar A. Ahmadiani Farzanch Sabahi |
| author_sort | Roya Yaraee |
| collection | DOAJ |
| description | Neuropeptides, possessing specific and functional receptors on various cells of the immune system, have the potential to regulate immune responses; and the macrophages as important components of defense against various agents, are at their influence. In this study the effect of neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) on IL-1 beta production by herpes sim¬plex type-1 (HSV-1 )-infected and also uninfected mouse peritoneal macrophages were considered. Each neuropeptide separately has upregulated IL-1 beta produc¬tion by HSV-1 infected macrophages with the greatest effect at the concentrations of 10'9M for both SP and CGRP, but no synergistic effect on IL-1 production has been observed in the presence of both neuropeptides at optimal concentrations. IL-ip production by uninfected macrophages was also moderately enhanced in the presence of each neuropeptide, but not in the presence of both neuropeptides simultaneously. It can be concluded that IL-1 S3 production, which is part of mac¬rophage mediated inflammatory response to HSV-1, is enhanced by specific doses of neuropeptides. |
| first_indexed | 2024-12-22T19:50:46Z |
| format | Article |
| id | doaj.art-e4208f1c591d4d0982ad3d7ca42854e7 |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-12-22T19:50:46Z |
| publishDate | 2003-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-e4208f1c591d4d0982ad3d7ca42854e72022-12-21T18:14:34ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492003-06-012240NEUROPEPTIDES (SP AND CGRP) AUGMENT IL-1 BETA PRODUCTION IN HSV-INFECTED MACROPHAGES Roya Yaraee0 Massoumeh Ebtekar1 A. Ahmadiani2 Farzanch Sabahi3 Neuropeptides, possessing specific and functional receptors on various cells of the immune system, have the potential to regulate immune responses; and the macrophages as important components of defense against various agents, are at their influence. In this study the effect of neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) on IL-1 beta production by herpes sim¬plex type-1 (HSV-1 )-infected and also uninfected mouse peritoneal macrophages were considered. Each neuropeptide separately has upregulated IL-1 beta produc¬tion by HSV-1 infected macrophages with the greatest effect at the concentrations of 10'9M for both SP and CGRP, but no synergistic effect on IL-1 production has been observed in the presence of both neuropeptides at optimal concentrations. IL-ip production by uninfected macrophages was also moderately enhanced in the presence of each neuropeptide, but not in the presence of both neuropeptides simultaneously. It can be concluded that IL-1 S3 production, which is part of mac¬rophage mediated inflammatory response to HSV-1, is enhanced by specific doses of neuropeptides.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/40Calcitonin Gene-Related PeptideMacrophageHerpes Simplex Virus Type -1Interleukin-lbeta |
| spellingShingle | Roya Yaraee Massoumeh Ebtekar A. Ahmadiani Farzanch Sabahi NEUROPEPTIDES (SP AND CGRP) AUGMENT IL-1 BETA PRODUCTION IN HSV-INFECTED MACROPHAGES Iranian Journal of Allergy, Asthma and Immunology Calcitonin Gene-Related Peptide Macrophage Herpes Simplex Virus Type -1 Interleukin-lbeta |
| title | NEUROPEPTIDES (SP AND CGRP) AUGMENT IL-1 BETA PRODUCTION IN HSV-INFECTED MACROPHAGES |
| title_full | NEUROPEPTIDES (SP AND CGRP) AUGMENT IL-1 BETA PRODUCTION IN HSV-INFECTED MACROPHAGES |
| title_fullStr | NEUROPEPTIDES (SP AND CGRP) AUGMENT IL-1 BETA PRODUCTION IN HSV-INFECTED MACROPHAGES |
| title_full_unstemmed | NEUROPEPTIDES (SP AND CGRP) AUGMENT IL-1 BETA PRODUCTION IN HSV-INFECTED MACROPHAGES |
| title_short | NEUROPEPTIDES (SP AND CGRP) AUGMENT IL-1 BETA PRODUCTION IN HSV-INFECTED MACROPHAGES |
| title_sort | neuropeptides sp and cgrp augment il 1 beta production in hsv infected macrophages |
| topic | Calcitonin Gene-Related Peptide Macrophage Herpes Simplex Virus Type -1 Interleukin-lbeta |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/40 |
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