Mesoporous Silica Nanoparticles for pH-Responsive Delivery of Iridium Metallotherapeutics and Treatment of Glioblastoma Multiforme
Using nanoparticles for controlled drug delivery to cancer, in response to its weakly acidic environment, represents a promising approach toward increasing the effectiveness and reducing the adverse effects of cancer therapy. Hence, the aim of this study is to construct novel mesoporous silica nanop...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Inorganics |
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| Online Access: | https://www.mdpi.com/2304-6740/10/12/250 |
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| author | Nikola Ž. Knežević Nebojša Ilić Goran N. Kaluđerović |
| author_facet | Nikola Ž. Knežević Nebojša Ilić Goran N. Kaluđerović |
| author_sort | Nikola Ž. Knežević |
| collection | DOAJ |
| description | Using nanoparticles for controlled drug delivery to cancer, in response to its weakly acidic environment, represents a promising approach toward increasing the effectiveness and reducing the adverse effects of cancer therapy. Hence, the aim of this study is to construct novel mesoporous silica nanoparticle (MSN)-based acidification-responsive drug delivery systems for targeted cancer therapy. Herein, the surface of MSN is covalently functionalized with Ir(III)-based complex through a pH-cleavable hydrazone-based linker and characterized by nitrogen sorption, SEM, FTIR, EDS, TGA, DSC, DLS, and zeta potential measurements. Enhanced release of Ir(III)-complexes is evidenced by UV/VIS spectroscopy at the weakly acidic environments (pH 5 and pH 6) in comparison to the release at physiological conditions. The in vitro toxicity of the prepared materials is tested on healthy MRC-5 cells while their potential for the efficient treatment of glioblastoma multiforme is demonstrated on the U251 cell line. |
| first_indexed | 2024-03-09T16:18:14Z |
| format | Article |
| id | doaj.art-e4249f336aa14db69388aa824eabc016 |
| institution | Directory Open Access Journal |
| issn | 2304-6740 |
| language | English |
| last_indexed | 2024-03-09T16:18:14Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Inorganics |
| spelling | doaj.art-e4249f336aa14db69388aa824eabc0162023-11-24T15:38:27ZengMDPI AGInorganics2304-67402022-12-01101225010.3390/inorganics10120250Mesoporous Silica Nanoparticles for pH-Responsive Delivery of Iridium Metallotherapeutics and Treatment of Glioblastoma MultiformeNikola Ž. Knežević0Nebojša Ilić1Goran N. Kaluđerović2BioSense Institute, University of Novi Sad, Dr. Zorana Đinđića 1, 21000 Novi Sad, SerbiaDepartment of Engineering and Natural Sciences, University of Applied Sciences Merseburg, Eberhard-Leibnitz-Strasse 2, 06217 Merseburg, GermanyDepartment of Engineering and Natural Sciences, University of Applied Sciences Merseburg, Eberhard-Leibnitz-Strasse 2, 06217 Merseburg, GermanyUsing nanoparticles for controlled drug delivery to cancer, in response to its weakly acidic environment, represents a promising approach toward increasing the effectiveness and reducing the adverse effects of cancer therapy. Hence, the aim of this study is to construct novel mesoporous silica nanoparticle (MSN)-based acidification-responsive drug delivery systems for targeted cancer therapy. Herein, the surface of MSN is covalently functionalized with Ir(III)-based complex through a pH-cleavable hydrazone-based linker and characterized by nitrogen sorption, SEM, FTIR, EDS, TGA, DSC, DLS, and zeta potential measurements. Enhanced release of Ir(III)-complexes is evidenced by UV/VIS spectroscopy at the weakly acidic environments (pH 5 and pH 6) in comparison to the release at physiological conditions. The in vitro toxicity of the prepared materials is tested on healthy MRC-5 cells while their potential for the efficient treatment of glioblastoma multiforme is demonstrated on the U251 cell line.https://www.mdpi.com/2304-6740/10/12/250pH-responsivedrug deliverycancer therapyIridium complexmetallotherapeuticsmesoporous silica nanoparticles |
| spellingShingle | Nikola Ž. Knežević Nebojša Ilić Goran N. Kaluđerović Mesoporous Silica Nanoparticles for pH-Responsive Delivery of Iridium Metallotherapeutics and Treatment of Glioblastoma Multiforme Inorganics pH-responsive drug delivery cancer therapy Iridium complex metallotherapeutics mesoporous silica nanoparticles |
| title | Mesoporous Silica Nanoparticles for pH-Responsive Delivery of Iridium Metallotherapeutics and Treatment of Glioblastoma Multiforme |
| title_full | Mesoporous Silica Nanoparticles for pH-Responsive Delivery of Iridium Metallotherapeutics and Treatment of Glioblastoma Multiforme |
| title_fullStr | Mesoporous Silica Nanoparticles for pH-Responsive Delivery of Iridium Metallotherapeutics and Treatment of Glioblastoma Multiforme |
| title_full_unstemmed | Mesoporous Silica Nanoparticles for pH-Responsive Delivery of Iridium Metallotherapeutics and Treatment of Glioblastoma Multiforme |
| title_short | Mesoporous Silica Nanoparticles for pH-Responsive Delivery of Iridium Metallotherapeutics and Treatment of Glioblastoma Multiforme |
| title_sort | mesoporous silica nanoparticles for ph responsive delivery of iridium metallotherapeutics and treatment of glioblastoma multiforme |
| topic | pH-responsive drug delivery cancer therapy Iridium complex metallotherapeutics mesoporous silica nanoparticles |
| url | https://www.mdpi.com/2304-6740/10/12/250 |
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