Distinct Dynamics of Migratory Response to PD-1 and CTLA-4 Blockade Reveals New Mechanistic Insights for Potential T-Cell Reinvigoration following Immune Checkpoint Blockade

Distinct Dynamics of Migratory Response to PD-1 and CTLA-4 Blockade Reveals New Mechanistic Insights for Potential T-Cell Reinvigoration following Immune Checkpoint Blockade

Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1), two clinically relevant targets for the immunotherapy of cancer, are negative regulators of T-cell activation and migration. Optimizing the therapeutic response to CTLA-4 and PD-1 blockade calls for a mo...

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Bibliographic Details
Main Authors: Fateme Safaeifard, Bahram Goliaei, Amir R. Aref, Mohammad-Hadi Foroughmand-Araabi, Sama Goliaei, Jochen Lorch, Russell W. Jenkins, David A. Barbie, Seyed Peyman Shariatpanahi, Curzio Rüegg
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
organotypic tumor culture
immune checkpoint blockade
T-cell migration
heterogeneous random walks
tumor–immune interaction
delayed dynamics
Online Access:https://www.mdpi.com/2073-4409/11/22/3534

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