Exploring New Mitochondria-Targetable Theragnostic styrylBODIPYs
Two analogs of a previous mitochondria-targetable theragnostic styrylBODIPY have been designed, synthesized, and submitted to preliminary studies in order to explore their capability to act as new theragnostic agents with absorption in the red region. The new dyes are obtained through a straightforw...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Chemistry Proceedings |
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| Online Access: | https://www.mdpi.com/2673-4583/8/1/41 |
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| author | Tania Mazuelo Sergio Serrano Fernando García-Garrido Josué Jiménez Carolina Díaz-Norambuena Beatriz L. Maroto Florencio Moreno Jorge Bañuelos Antonia R. Agarrabeitia Ángeles Villanueva Santiago de la Moya María J. Ortiz |
| author_facet | Tania Mazuelo Sergio Serrano Fernando García-Garrido Josué Jiménez Carolina Díaz-Norambuena Beatriz L. Maroto Florencio Moreno Jorge Bañuelos Antonia R. Agarrabeitia Ángeles Villanueva Santiago de la Moya María J. Ortiz |
| author_sort | Tania Mazuelo |
| collection | DOAJ |
| description | Two analogs of a previous mitochondria-targetable theragnostic styrylBODIPY have been designed, synthesized, and submitted to preliminary studies in order to explore their capability to act as new theragnostic agents with absorption in the red region. The new dyes are obtained through a straightforward and low-cost synthetic protocol and have styryl moieties bearing non-delocalized cations (trimethylammonium) attached to the BODIPY through a spacer, or directly linked. Preliminary results of them in cell bioimaging showed internalization into HeLa cells and accumulation into mitochondria. Photodynamic therapy was also analyzed, demonstrating the viability of this red styrylBODIPY as mitochondria-targetable photo-theragnostic agent. |
| first_indexed | 2024-03-11T06:47:08Z |
| format | Article |
| id | doaj.art-e42583b89a8d46c7885b0bd2b3e94d99 |
| institution | Directory Open Access Journal |
| issn | 2673-4583 |
| language | English |
| last_indexed | 2024-03-11T06:47:08Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemistry Proceedings |
| spelling | doaj.art-e42583b89a8d46c7885b0bd2b3e94d992023-11-17T10:18:31ZengMDPI AGChemistry Proceedings2673-45832021-11-01814110.3390/ecsoc-25-11677Exploring New Mitochondria-Targetable Theragnostic styrylBODIPYsTania Mazuelo0Sergio Serrano1Fernando García-Garrido2Josué Jiménez3Carolina Díaz-Norambuena4Beatriz L. Maroto5Florencio Moreno6Jorge Bañuelos7Antonia R. Agarrabeitia8Ángeles Villanueva9Santiago de la Moya10María J. Ortiz11Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, SpainDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, SpainDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, SpainDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, SpainDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, SpainDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, SpainDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, SpainDepartamento de Química Física, Facultad de Ciencia y Tecnología, Universidad del País Vasco-EHU, 48080 Bilbao, SpainDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, SpainDepartamento de Biología, Universidad Autónoma de Madrid, Darwin 2, 28049 Madrid, SpainDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, SpainDepartamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Ciudad Universitaria s/n, 28040 Madrid, SpainTwo analogs of a previous mitochondria-targetable theragnostic styrylBODIPY have been designed, synthesized, and submitted to preliminary studies in order to explore their capability to act as new theragnostic agents with absorption in the red region. The new dyes are obtained through a straightforward and low-cost synthetic protocol and have styryl moieties bearing non-delocalized cations (trimethylammonium) attached to the BODIPY through a spacer, or directly linked. Preliminary results of them in cell bioimaging showed internalization into HeLa cells and accumulation into mitochondria. Photodynamic therapy was also analyzed, demonstrating the viability of this red styrylBODIPY as mitochondria-targetable photo-theragnostic agent.https://www.mdpi.com/2673-4583/8/1/41red-BODIPYsmitochondriaphotodynamic therapybioimagingtheragnosis |
| spellingShingle | Tania Mazuelo Sergio Serrano Fernando García-Garrido Josué Jiménez Carolina Díaz-Norambuena Beatriz L. Maroto Florencio Moreno Jorge Bañuelos Antonia R. Agarrabeitia Ángeles Villanueva Santiago de la Moya María J. Ortiz Exploring New Mitochondria-Targetable Theragnostic styrylBODIPYs Chemistry Proceedings red-BODIPYs mitochondria photodynamic therapy bioimaging theragnosis |
| title | Exploring New Mitochondria-Targetable Theragnostic styrylBODIPYs |
| title_full | Exploring New Mitochondria-Targetable Theragnostic styrylBODIPYs |
| title_fullStr | Exploring New Mitochondria-Targetable Theragnostic styrylBODIPYs |
| title_full_unstemmed | Exploring New Mitochondria-Targetable Theragnostic styrylBODIPYs |
| title_short | Exploring New Mitochondria-Targetable Theragnostic styrylBODIPYs |
| title_sort | exploring new mitochondria targetable theragnostic styrylbodipys |
| topic | red-BODIPYs mitochondria photodynamic therapy bioimaging theragnosis |
| url | https://www.mdpi.com/2673-4583/8/1/41 |
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