Mechanisms of small cell lung cancer metastasis
Abstract Metastasis is a major cause of morbidity and mortality in cancer patients. However, the molecular and cellular mechanisms underlying the ability of cancer cells to metastasize remain relatively poorly understood. Among all solid tumors, small cell lung cancer (SCLC) has remarkable metastati...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Springer Nature
2021-01-01
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| Series: | EMBO Molecular Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.15252/emmm.202013122 |
| _version_ | 1797281981083418624 |
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| author | Julie Ko Monte M Winslow Julien Sage |
| author_facet | Julie Ko Monte M Winslow Julien Sage |
| author_sort | Julie Ko |
| collection | DOAJ |
| description | Abstract Metastasis is a major cause of morbidity and mortality in cancer patients. However, the molecular and cellular mechanisms underlying the ability of cancer cells to metastasize remain relatively poorly understood. Among all solid tumors, small cell lung cancer (SCLC) has remarkable metastatic proclivity, with a majority of patients diagnosed with metastatic disease. Our understanding of SCLC metastasis has been hampered for many years by the paucity of material from primary tumors and metastases, as well as the lack of faithful pre‐clinical models. Here, we review recent advances that are helping circumvent these limitations. These advances include methods that employ circulating tumor cells from the blood of SCLC patients and the development of diverse genetically engineered mouse models of metastatic SCLC. New insights into the cellular mechanisms of SCLC metastasis include observations of cell fate changes associated with increased metastatic ability. Ongoing studies on cell migration and organ tropism promise to expand our understanding of SCLC metastasis. Ultimately, a better molecular understanding of metastatic phenotypes may be translated into new therapeutic options to limit metastatic spread and treat metastatic SCLC. |
| first_indexed | 2024-03-07T17:05:24Z |
| format | Article |
| id | doaj.art-e4274c505136492c949d915ee2d01d12 |
| institution | Directory Open Access Journal |
| issn | 1757-4676 1757-4684 |
| language | English |
| last_indexed | 2024-03-07T17:05:24Z |
| publishDate | 2021-01-01 |
| publisher | Springer Nature |
| record_format | Article |
| series | EMBO Molecular Medicine |
| spelling | doaj.art-e4274c505136492c949d915ee2d01d122024-03-03T02:46:54ZengSpringer NatureEMBO Molecular Medicine1757-46761757-46842021-01-01131n/an/a10.15252/emmm.202013122Mechanisms of small cell lung cancer metastasisJulie Ko0Monte M Winslow1Julien Sage2Department of Pediatrics Stanford University Stanford CA USADepartment of Genetics Stanford University Stanford CA USADepartment of Pediatrics Stanford University Stanford CA USAAbstract Metastasis is a major cause of morbidity and mortality in cancer patients. However, the molecular and cellular mechanisms underlying the ability of cancer cells to metastasize remain relatively poorly understood. Among all solid tumors, small cell lung cancer (SCLC) has remarkable metastatic proclivity, with a majority of patients diagnosed with metastatic disease. Our understanding of SCLC metastasis has been hampered for many years by the paucity of material from primary tumors and metastases, as well as the lack of faithful pre‐clinical models. Here, we review recent advances that are helping circumvent these limitations. These advances include methods that employ circulating tumor cells from the blood of SCLC patients and the development of diverse genetically engineered mouse models of metastatic SCLC. New insights into the cellular mechanisms of SCLC metastasis include observations of cell fate changes associated with increased metastatic ability. Ongoing studies on cell migration and organ tropism promise to expand our understanding of SCLC metastasis. Ultimately, a better molecular understanding of metastatic phenotypes may be translated into new therapeutic options to limit metastatic spread and treat metastatic SCLC.https://doi.org/10.15252/emmm.202013122lung cancermetastasisNFIBSCLCtumor heterogeneity |
| spellingShingle | Julie Ko Monte M Winslow Julien Sage Mechanisms of small cell lung cancer metastasis EMBO Molecular Medicine lung cancer metastasis NFIB SCLC tumor heterogeneity |
| title | Mechanisms of small cell lung cancer metastasis |
| title_full | Mechanisms of small cell lung cancer metastasis |
| title_fullStr | Mechanisms of small cell lung cancer metastasis |
| title_full_unstemmed | Mechanisms of small cell lung cancer metastasis |
| title_short | Mechanisms of small cell lung cancer metastasis |
| title_sort | mechanisms of small cell lung cancer metastasis |
| topic | lung cancer metastasis NFIB SCLC tumor heterogeneity |
| url | https://doi.org/10.15252/emmm.202013122 |
| work_keys_str_mv | AT julieko mechanismsofsmallcelllungcancermetastasis AT montemwinslow mechanismsofsmallcelllungcancermetastasis AT juliensage mechanismsofsmallcelllungcancermetastasis |