Vial Sharing of High-Cost Drugs to Decrease Leftovers and Costs: A Retrospective Observational Study on Patisiran Administration in Bologna, Italy
Waste of high-cost medicines, such as orphan drugs, is a major problem in healthcare, which leads to excessive costs for treatments. The main objective of this study was to evaluate the impact of a vial-sharing strategy for patisiran, an orphan drug used for the treatment of hereditary transthyretin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/11/7/1013 |
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| author | Margherita Cozzio Alessandro Melis Giusy La Fauci Pietro Guaraldi Rosaria Caputo Flavia Lioi Giulia Sangiorgi Cellini Giuseppina Santilli Donatella Scarlattei Pasquale Siravo Paola Zuccheri Andrea Ziglio Marco Montalti |
| author_facet | Margherita Cozzio Alessandro Melis Giusy La Fauci Pietro Guaraldi Rosaria Caputo Flavia Lioi Giulia Sangiorgi Cellini Giuseppina Santilli Donatella Scarlattei Pasquale Siravo Paola Zuccheri Andrea Ziglio Marco Montalti |
| author_sort | Margherita Cozzio |
| collection | DOAJ |
| description | Waste of high-cost medicines, such as orphan drugs, is a major problem in healthcare, which leads to excessive costs for treatments. The main objective of this study was to evaluate the impact of a vial-sharing strategy for patisiran, an orphan drug used for the treatment of hereditary transthyretin-mediated amyloidosis, in terms of a reduction in the discarded drug amount and cost savings. The retrospective observational study was conducted in a tertiary referral center (Emilia-Romagna, Italy), between February 2021 and November 2022. Data on drug waste were calculated as “(mg used–mg prescribed)/mg prescribed” for each session. We found a statistically significant (−9.14%, <i>p</i> < 0.001, 95% CI 5.87–12.41) absolute difference in mean discarded drug rates per session based on the study phase (before and after vial-sharing introduction) at the two-sample t-test. The absolute difference corresponded to a percentage decrease in the average reduction in the discarded drug rate with vial sharing of 82.96% per session. On an annual scale, the estimated cost savings was EUR 26,203.80/year for a patient with a standard body weight of 70 kg. In conclusion, we demonstrated that a patisiran vial-sharing program undoubtedly offsets some of the high costs associated with this treatment. We suggest that this easy-to-introduce and cost-effective approach can be applied to the administration of other high-cost drugs. |
| first_indexed | 2024-03-11T05:37:18Z |
| format | Article |
| id | doaj.art-e428cc0fef1a494a9f92de2506b7af57 |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-11T05:37:18Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-e428cc0fef1a494a9f92de2506b7af572023-11-17T16:44:10ZengMDPI AGHealthcare2227-90322023-04-01117101310.3390/healthcare11071013Vial Sharing of High-Cost Drugs to Decrease Leftovers and Costs: A Retrospective Observational Study on Patisiran Administration in Bologna, ItalyMargherita Cozzio0Alessandro Melis1Giusy La Fauci2Pietro Guaraldi3Rosaria Caputo4Flavia Lioi5Giulia Sangiorgi Cellini6Giuseppina Santilli7Donatella Scarlattei8Pasquale Siravo9Paola Zuccheri10Andrea Ziglio11Marco Montalti12Unit of Hygiene and Medical Statistics, Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, ItalyUnit of Hygiene and Medical Statistics, Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, ItalyUnit of Hygiene and Medical Statistics, Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, ItalyUnit of Clinical Neurology NEUROMET, IRCCS Institute of Neurological Sciences of Bologna, 40139 Bologna, ItalyPharmacy Unit for Cytotoxic Drug Preparations, Bellaria Hospital, Intercompany Pharmaceutical Department, Bologna Local Health Authority, 40139 Bologna, ItalyPharmacy Unit for Cytotoxic Drug Preparations, Bellaria Hospital, Intercompany Pharmaceutical Department, Bologna Local Health Authority, 40139 Bologna, ItalyPharmacy Unit for Cytotoxic Drug Preparations, Bellaria Hospital, Intercompany Pharmaceutical Department, Bologna Local Health Authority, 40139 Bologna, ItalyPharmacy Unit for Cytotoxic Drug Preparations, Bellaria Hospital, Intercompany Pharmaceutical Department, Bologna Local Health Authority, 40139 Bologna, ItalyPharmacy Unit for Cytotoxic Drug Preparations, Bellaria Hospital, Intercompany Pharmaceutical Department, Bologna Local Health Authority, 40139 Bologna, ItalyPharmacy Unit for Cytotoxic Drug Preparations, Bellaria Hospital, Intercompany Pharmaceutical Department, Bologna Local Health Authority, 40139 Bologna, ItalyPharmacy Unit for Cytotoxic Drug Preparations, Bellaria Hospital, Intercompany Pharmaceutical Department, Bologna Local Health Authority, 40139 Bologna, ItalyUnit of Hospital Management, IRCCS Institute of Neurological Sciences of Bologna, 40139 Bologna, ItalyUnit of Hygiene and Medical Statistics, Department of Biomedical and Neuromotor Sciences, University of Bologna, 40126 Bologna, ItalyWaste of high-cost medicines, such as orphan drugs, is a major problem in healthcare, which leads to excessive costs for treatments. The main objective of this study was to evaluate the impact of a vial-sharing strategy for patisiran, an orphan drug used for the treatment of hereditary transthyretin-mediated amyloidosis, in terms of a reduction in the discarded drug amount and cost savings. The retrospective observational study was conducted in a tertiary referral center (Emilia-Romagna, Italy), between February 2021 and November 2022. Data on drug waste were calculated as “(mg used–mg prescribed)/mg prescribed” for each session. We found a statistically significant (−9.14%, <i>p</i> < 0.001, 95% CI 5.87–12.41) absolute difference in mean discarded drug rates per session based on the study phase (before and after vial-sharing introduction) at the two-sample t-test. The absolute difference corresponded to a percentage decrease in the average reduction in the discarded drug rate with vial sharing of 82.96% per session. On an annual scale, the estimated cost savings was EUR 26,203.80/year for a patient with a standard body weight of 70 kg. In conclusion, we demonstrated that a patisiran vial-sharing program undoubtedly offsets some of the high costs associated with this treatment. We suggest that this easy-to-introduce and cost-effective approach can be applied to the administration of other high-cost drugs.https://www.mdpi.com/2227-9032/11/7/1013drug compoundingpatisiranhATTR amyloidosisdrug daysustainabilitypharmaceutical spending |
| spellingShingle | Margherita Cozzio Alessandro Melis Giusy La Fauci Pietro Guaraldi Rosaria Caputo Flavia Lioi Giulia Sangiorgi Cellini Giuseppina Santilli Donatella Scarlattei Pasquale Siravo Paola Zuccheri Andrea Ziglio Marco Montalti Vial Sharing of High-Cost Drugs to Decrease Leftovers and Costs: A Retrospective Observational Study on Patisiran Administration in Bologna, Italy Healthcare drug compounding patisiran hATTR amyloidosis drug day sustainability pharmaceutical spending |
| title | Vial Sharing of High-Cost Drugs to Decrease Leftovers and Costs: A Retrospective Observational Study on Patisiran Administration in Bologna, Italy |
| title_full | Vial Sharing of High-Cost Drugs to Decrease Leftovers and Costs: A Retrospective Observational Study on Patisiran Administration in Bologna, Italy |
| title_fullStr | Vial Sharing of High-Cost Drugs to Decrease Leftovers and Costs: A Retrospective Observational Study on Patisiran Administration in Bologna, Italy |
| title_full_unstemmed | Vial Sharing of High-Cost Drugs to Decrease Leftovers and Costs: A Retrospective Observational Study on Patisiran Administration in Bologna, Italy |
| title_short | Vial Sharing of High-Cost Drugs to Decrease Leftovers and Costs: A Retrospective Observational Study on Patisiran Administration in Bologna, Italy |
| title_sort | vial sharing of high cost drugs to decrease leftovers and costs a retrospective observational study on patisiran administration in bologna italy |
| topic | drug compounding patisiran hATTR amyloidosis drug day sustainability pharmaceutical spending |
| url | https://www.mdpi.com/2227-9032/11/7/1013 |
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