Exploring Structure–Activity Relationships of Niclosamide-Based Colistin Potentiators in Colistin-Resistant Gram-Negative Bacteria

Exploring Structure–Activity Relationships of Niclosamide-Based Colistin Potentiators in Colistin-Resistant Gram-Negative Bacteria

Colistin is primarily used as a last resort antibiotic against highly resistant Gram-negative bacteria (GNB). Rising rates of colistin resistance, however, may limit future use of this agent. The anthelmintic drug niclosamide has been shown to enhance colistin activity in combination therapy, but a...

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Bibliographic Details
Main Authors: Liam Berry, Quinn Neale, Rajat Arora, Danyel Ramirez, Marc Brizuela, Ronald Domalaon, Gilbert Arthur, Frank Schweizer
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Antibiotics
Subjects:
colistin
niclosamide
antibiotic
adjuvant
Gram-negative bacteria
Online Access:https://www.mdpi.com/2079-6382/13/1/43

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