S100 Proteins as Novel Therapeutic Targets in Psoriasis and Other Autoimmune Diseases
Psoriasis is one of the most common inflammatory skin diseases affecting about 1–3% of the population. One of the characteristic abnormalities in psoriasis is the excessive production of antimicrobial peptides and proteins, which play an essential role in the pathogenesis of the disease. Antimicrobi...
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| Format: | Artykuł |
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MDPI AG
2022-10-01
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| Seria: | Molecules |
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| Dostęp online: | https://www.mdpi.com/1420-3049/27/19/6640 |
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| author | Katarzyna Kurpet Grażyna Chwatko |
| author_facet | Katarzyna Kurpet Grażyna Chwatko |
| author_sort | Katarzyna Kurpet |
| collection | DOAJ |
| description | Psoriasis is one of the most common inflammatory skin diseases affecting about 1–3% of the population. One of the characteristic abnormalities in psoriasis is the excessive production of antimicrobial peptides and proteins, which play an essential role in the pathogenesis of the disease. Antimicrobial peptides and proteins can be expressed differently in normal and diseased skin, reflecting their usefulness as diagnostic biomarkers. Moreover, due to their very important functions in innate immunity, members of host defense peptides and proteins are currently considered to be promising new therapeutic targets for many inflammatory diseases. Koebnerisin (S100A15) belongs to an S100 family of antimicrobial proteins, which constitute the multigenetic group of calcium-binding proteins involved in ion-dependent cellular functions and regulation of immune mechanisms. S100A15 was first discovered to be overexpressed in ‘koebnerized’ psoriatic skin, indicating its involvement in the disease phenotype and the same promising potential as a new therapeutic target. This review describes the involvement of antimicrobial peptides and proteins in inflammatory diseases’ development and therapy. The discussion focuses on S100 proteins, especially koebnerisin, which may be involved in the underlying mechanism of the Köebner phenomenon in psoriasis, as well as other immune-mediated inflammatory diseases described in the last decade. |
| first_indexed | 2024-03-09T21:24:10Z |
| format | Article |
| id | doaj.art-e42ef3d140a74e8b95bcc9e1de1e9ca5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T21:24:10Z |
| publishDate | 2022-10-01 |
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| series | Molecules |
| spelling | doaj.art-e42ef3d140a74e8b95bcc9e1de1e9ca52023-11-23T21:14:44ZengMDPI AGMolecules1420-30492022-10-012719664010.3390/molecules27196640S100 Proteins as Novel Therapeutic Targets in Psoriasis and Other Autoimmune DiseasesKatarzyna Kurpet0Grażyna Chwatko1Doctoral School of Exact and Natural Sciences, University of Lodz, Banacha 12/16, 90-237 Lodz, PolandDepartment of Environmental Chemistry, Faculty of Chemistry, University of Lodz, Pomorska 163/165, 90-236 Lodz, PolandPsoriasis is one of the most common inflammatory skin diseases affecting about 1–3% of the population. One of the characteristic abnormalities in psoriasis is the excessive production of antimicrobial peptides and proteins, which play an essential role in the pathogenesis of the disease. Antimicrobial peptides and proteins can be expressed differently in normal and diseased skin, reflecting their usefulness as diagnostic biomarkers. Moreover, due to their very important functions in innate immunity, members of host defense peptides and proteins are currently considered to be promising new therapeutic targets for many inflammatory diseases. Koebnerisin (S100A15) belongs to an S100 family of antimicrobial proteins, which constitute the multigenetic group of calcium-binding proteins involved in ion-dependent cellular functions and regulation of immune mechanisms. S100A15 was first discovered to be overexpressed in ‘koebnerized’ psoriatic skin, indicating its involvement in the disease phenotype and the same promising potential as a new therapeutic target. This review describes the involvement of antimicrobial peptides and proteins in inflammatory diseases’ development and therapy. The discussion focuses on S100 proteins, especially koebnerisin, which may be involved in the underlying mechanism of the Köebner phenomenon in psoriasis, as well as other immune-mediated inflammatory diseases described in the last decade.https://www.mdpi.com/1420-3049/27/19/6640psoriasisS100 proteinskoebnerisinantimicrobial peptides and proteinsimmune-mediated inflammatory diseasesbiomarkers |
| spellingShingle | Katarzyna Kurpet Grażyna Chwatko S100 Proteins as Novel Therapeutic Targets in Psoriasis and Other Autoimmune Diseases Molecules psoriasis S100 proteins koebnerisin antimicrobial peptides and proteins immune-mediated inflammatory diseases biomarkers |
| title | S100 Proteins as Novel Therapeutic Targets in Psoriasis and Other Autoimmune Diseases |
| title_full | S100 Proteins as Novel Therapeutic Targets in Psoriasis and Other Autoimmune Diseases |
| title_fullStr | S100 Proteins as Novel Therapeutic Targets in Psoriasis and Other Autoimmune Diseases |
| title_full_unstemmed | S100 Proteins as Novel Therapeutic Targets in Psoriasis and Other Autoimmune Diseases |
| title_short | S100 Proteins as Novel Therapeutic Targets in Psoriasis and Other Autoimmune Diseases |
| title_sort | s100 proteins as novel therapeutic targets in psoriasis and other autoimmune diseases |
| topic | psoriasis S100 proteins koebnerisin antimicrobial peptides and proteins immune-mediated inflammatory diseases biomarkers |
| url | https://www.mdpi.com/1420-3049/27/19/6640 |
| work_keys_str_mv | AT katarzynakurpet s100proteinsasnoveltherapeutictargetsinpsoriasisandotherautoimmunediseases AT grazynachwatko s100proteinsasnoveltherapeutictargetsinpsoriasisandotherautoimmunediseases |